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Mesoporous magnesium silicate-incorporated poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) bioactive composite beneficial to osteoblast behaviors
Niu, YF; Dong, W; Guo, H; Deng, YH; Guo, LP; An, XF; He, DW; Wei, J; Li, M; dyt901208@qq.com; niuy1111@163.com
2014
Source PublicationINTERNATIONAL JOURNAL OF NANOMEDICINE
ISSN1178-2013
Volume9Pages:2665—2675
AbstractMesoporous magnesium silicate (m-MS) and poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) (PCL-PEG-PCL) composite (m-MPC) was synthesized by solvent casting method. The results suggest that the mechanical properties of compressive strength and elastic modulus, as well as hydrophilicity, of the m-MPC increased with increase of m-MS content in the composites. In addition, the weight loss of the m-MPC improved significantly with the increase of m-MS content during composite soaking in phosphate-buffered saline for 10 weeks, indicating that incorporation of m-MS into PCL-PEG-PCL could enhance the degradability of the m-MPC. Moreover, the m-MPC with 40 w% m-MS could induce a dense and continuous apatite layer on its surface after soaking in simulated body fluid for 5 days, which was better than m-MPC 20 w% m-MS, exhibiting excellent in vitro bioactivity. In cell cultural experiments, the results showed that the attachment and viability ratio of MG63 cells on m-MPC increased significantly with the increase of m-MS content, showing that the addition of m-MS into PCL-PEG-PCL could promote cell attachment and proliferation. The results suggest that the incorporation of m-MS into PCL-PEG-PCL could produce bioactive composites with improved hydrophilicity, degradability, bioactivity, and cytocompatibility.
KeywordSimulated Body-fluid Drug-delivery Hydrogel Release Degradation Scaffolds Template Implants
Indexed BySCI
Language英语
WOS IDWOS:000336442700002
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/14244
Collection中科院上海应用物理研究所2011-2019年
Corresponding Authordyt901208@qq.com; niuy1111@163.com
Recommended Citation
GB/T 7714
Niu, YF,Dong, W,Guo, H,et al. Mesoporous magnesium silicate-incorporated poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) bioactive composite beneficial to osteoblast behaviors[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2014,9:2665—2675.
APA Niu, YF.,Dong, W.,Guo, H.,Deng, YH.,Guo, LP.,...&niuy1111@163.com.(2014).Mesoporous magnesium silicate-incorporated poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) bioactive composite beneficial to osteoblast behaviors.INTERNATIONAL JOURNAL OF NANOMEDICINE,9,2665—2675.
MLA Niu, YF,et al."Mesoporous magnesium silicate-incorporated poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) bioactive composite beneficial to osteoblast behaviors".INTERNATIONAL JOURNAL OF NANOMEDICINE 9(2014):2665—2675.
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