Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| Molecular Logic Gates on DNA Origami Nanostructures for MicroRNA Diagnostics | |
| Wang, DF; Fu, YM; Yan, J; Zhao, B; Dai, B; Chao, J; Liu, HJ; He, DN; Zhang, Y; Fan, CH; Song, SP; spsong@sinap.ac.cn | |
| 2014 | |
| Source Publication | ANALYTICAL CHEMISTRY
 |
| ISSN | 0003-2700 |
| Volume | 86Issue:4Pages:1932—1936 |
| Abstract | Molecular computing holds great promise for I diagnosis and treatment of diseases at the molecular level; nevertheless, designing molecular logic gates to operate programmably and autonomously for molecular diagnostics still remains challenging. We designed logic gates on DNA Origami for microRNA analysis. As a demonstration, two indicators of heart failure, microRNA-21 and microRNA-195, were selected as the logic inputs. The logic gates contain two main modules: computation module and output module, performing in a single DNA Origami nanostructure. The computation module recognizes disease indicators, while the output module display different nanoscale symbols, "+" (positive) or "-" (negative), depending on the computing results. We demonstrated that the molecular logic gates worked well with single and two input combinations. |
| Keyword | Mammalian-cells Heart-failure Computation Identification Biomolecules Computer |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000331775600002 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/14248 |
| Collection | 中科院上海应用物理研究所2011-2019年 |
| Corresponding Author | spsong@sinap.ac.cn |
| Recommended Citation GB/T 7714 | Wang, DF,Fu, YM,Yan, J,et al. Molecular Logic Gates on DNA Origami Nanostructures for MicroRNA Diagnostics[J]. ANALYTICAL CHEMISTRY,2014,86(4):1932—1936. |
| APA | Wang, DF.,Fu, YM.,Yan, J.,Zhao, B.,Dai, B.,...&spsong@sinap.ac.cn.(2014).Molecular Logic Gates on DNA Origami Nanostructures for MicroRNA Diagnostics.ANALYTICAL CHEMISTRY,86(4),1932—1936. |
| MLA | Wang, DF,et al."Molecular Logic Gates on DNA Origami Nanostructures for MicroRNA Diagnostics".ANALYTICAL CHEMISTRY 86.4(2014):1932—1936. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Molecular Logic Gate（2374KB） | 开放获取 | CC BY-NC-SA | View Application Full Text | |||
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