Molecular Logic Gates on DNA Origami Nanostructures for MicroRNA Diagnostics

CAS OpenIR > 中科院上海应用物理研究所2011-2020年

	Molecular Logic Gates on DNA Origami Nanostructures for MicroRNA Diagnostics
	Wang, DF; Fu, YM; Yan, J; Zhao, B; Dai, B; Chao, J; Liu, HJ; He, DN; Zhang, Y; Fan, CH; Song, SP; spsong@sinap.ac.cn
	2014
Source Publication	ANALYTICAL CHEMISTRY
ISSN	0003-2700
Volume	86 Issue:4 Pages:1932—1936
Abstract	Molecular computing holds great promise for I diagnosis and treatment of diseases at the molecular level; nevertheless, designing molecular logic gates to operate programmably and autonomously for molecular diagnostics still remains challenging. We designed logic gates on DNA Origami for microRNA analysis. As a demonstration, two indicators of heart failure, microRNA-21 and microRNA-195, were selected as the logic inputs. The logic gates contain two main modules: computation module and output module, performing in a single DNA Origami nanostructure. The computation module recognizes disease indicators, while the output module display different nanoscale symbols, "+" (positive) or "-" (negative), depending on the computing results. We demonstrated that the molecular logic gates worked well with single and two input combinations.
Keyword	Mammalian-cells Heart-failure Computation Identification Biomolecules Computer
Indexed By	SCI
Language	英语
WOS ID	WOS:000331775600002
Citation statistics	Cited Times:80[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.sinap.ac.cn/handle/331007/14248
Collection	中科院上海应用物理研究所2011-2020年
Corresponding Author	spsong@sinap.ac.cn
Recommended Citation GB/T 7714	Wang, DF,Fu, YM,Yan, J,et al. Molecular Logic Gates on DNA Origami Nanostructures for MicroRNA Diagnostics[J]. ANALYTICAL CHEMISTRY,2014,86(4):1932—1936.
APA	Wang, DF.,Fu, YM.,Yan, J.,Zhao, B.,Dai, B.,...&spsong@sinap.ac.cn.(2014).Molecular Logic Gates on DNA Origami Nanostructures for MicroRNA Diagnostics.ANALYTICAL CHEMISTRY,86(4),1932—1936.
MLA	Wang, DF,et al."Molecular Logic Gates on DNA Origami Nanostructures for MicroRNA Diagnostics".ANALYTICAL CHEMISTRY 86.4(2014):1932—1936.

Files in This Item:
File Name/Size	DocType	Version	Access	License
Molecular Logic Gate（2374KB）			开放获取	CC BY-NC-SA	View Application Full Text

File name:	Molecular Logic Gates on DNA Origami Nanostructures for MicroRNA Diagnostics.pdf
Format:	Adobe PDF

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Institution:
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh

中国科学院上海应用物理研究所机构知识库