CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Molecular Logic Gates on DNA Origami Nanostructures for MicroRNA Diagnostics
Wang, DF; Fu, YM; Yan, J; Zhao, B; Dai, B; Chao, J; Liu, HJ; He, DN; Zhang, Y; Fan, CH; Song, SP; spsong@sinap.ac.cn
2014
Source PublicationANALYTICAL CHEMISTRY
ISSN0003-2700
Volume86Issue:4Pages:1932—1936
AbstractMolecular computing holds great promise for I diagnosis and treatment of diseases at the molecular level; nevertheless, designing molecular logic gates to operate programmably and autonomously for molecular diagnostics still remains challenging. We designed logic gates on DNA Origami for microRNA analysis. As a demonstration, two indicators of heart failure, microRNA-21 and microRNA-195, were selected as the logic inputs. The logic gates contain two main modules: computation module and output module, performing in a single DNA Origami nanostructure. The computation module recognizes disease indicators, while the output module display different nanoscale symbols, "+" (positive) or "-" (negative), depending on the computing results. We demonstrated that the molecular logic gates worked well with single and two input combinations.
KeywordMammalian-cells Heart-failure Computation Identification Biomolecules Computer
Indexed BySCI
Language英语
WOS IDWOS:000331775600002
Citation statistics
Cited Times:75[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/14248
Collection中科院上海应用物理研究所2011-2019年
Corresponding Authorspsong@sinap.ac.cn
Recommended Citation
GB/T 7714
Wang, DF,Fu, YM,Yan, J,et al. Molecular Logic Gates on DNA Origami Nanostructures for MicroRNA Diagnostics[J]. ANALYTICAL CHEMISTRY,2014,86(4):1932—1936.
APA Wang, DF.,Fu, YM.,Yan, J.,Zhao, B.,Dai, B.,...&spsong@sinap.ac.cn.(2014).Molecular Logic Gates on DNA Origami Nanostructures for MicroRNA Diagnostics.ANALYTICAL CHEMISTRY,86(4),1932—1936.
MLA Wang, DF,et al."Molecular Logic Gates on DNA Origami Nanostructures for MicroRNA Diagnostics".ANALYTICAL CHEMISTRY 86.4(2014):1932—1936.
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