Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
Molecular Logic Gates on DNA Origami Nanostructures for MicroRNA Diagnostics | |
Wang, DF; Fu, YM; Yan, J; Zhao, B; Dai, B; Chao, J; Liu, HJ; He, DN; Zhang, Y; Fan, CH; Song, SP; spsong@sinap.ac.cn | |
2014 | |
Source Publication | ANALYTICAL CHEMISTRY
![]() |
ISSN | 0003-2700 |
Volume | 86Issue:4Pages:1932—1936 |
Abstract | Molecular computing holds great promise for I diagnosis and treatment of diseases at the molecular level; nevertheless, designing molecular logic gates to operate programmably and autonomously for molecular diagnostics still remains challenging. We designed logic gates on DNA Origami for microRNA analysis. As a demonstration, two indicators of heart failure, microRNA-21 and microRNA-195, were selected as the logic inputs. The logic gates contain two main modules: computation module and output module, performing in a single DNA Origami nanostructure. The computation module recognizes disease indicators, while the output module display different nanoscale symbols, "+" (positive) or "-" (negative), depending on the computing results. We demonstrated that the molecular logic gates worked well with single and two input combinations. |
Keyword | Mammalian-cells Heart-failure Computation Identification Biomolecules Computer |
Indexed By | SCI |
Language | 英语 |
WOS ID | WOS:000331775600002 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.sinap.ac.cn/handle/331007/14248 |
Collection | 中科院上海应用物理研究所2011-2020年 |
Corresponding Author | spsong@sinap.ac.cn |
Recommended Citation GB/T 7714 | Wang, DF,Fu, YM,Yan, J,et al. Molecular Logic Gates on DNA Origami Nanostructures for MicroRNA Diagnostics[J]. ANALYTICAL CHEMISTRY,2014,86(4):1932—1936. |
APA | Wang, DF.,Fu, YM.,Yan, J.,Zhao, B.,Dai, B.,...&spsong@sinap.ac.cn.(2014).Molecular Logic Gates on DNA Origami Nanostructures for MicroRNA Diagnostics.ANALYTICAL CHEMISTRY,86(4),1932—1936. |
MLA | Wang, DF,et al."Molecular Logic Gates on DNA Origami Nanostructures for MicroRNA Diagnostics".ANALYTICAL CHEMISTRY 86.4(2014):1932—1936. |
Files in This Item: | Download All | |||||
File Name/Size | DocType | Version | Access | License | ||
Molecular Logic Gate(2374KB) | 开放获取 | CC BY-NC-SA | View Download |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment