CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Morphological effect of oscillating magnetic nanoparticles in killing tumor cells
Cheng, DF; Li, X; Zhang, GX; Shi, HC; zhangguoxin@sinap.ac.cn; shi.hongcheng@zs-hospital.sh.cn
2014
Source PublicationNANOSCALE RESEARCH LETTERS
ISSN1556-276X
Volume9
AbstractForced oscillation of spherical and rod-shaped iron oxide magnetic nanoparticles (MNPs) via low-power and low-frequency alternating magnetic field (AMF) was firstly used to kill cancer cells in vitro. After being loaded by human cervical cancer cells line (HeLa) and then exposed to a 35-kHz AMF, MNPs mechanically damaged cell membranes and cytoplasm, decreasing the cell viability. It was found that the concentration and morphology of the MNPs significantly influenced the cell-killing efficiency of oscillating MNPs. In this preliminary study, when HeLa cells were pre-incubated with 100 mu g/mL rod-shaped MNPs (rMNP, length of 200 +/- 50 nm and diameter of 50 to 120 nm) for 20 h, MTT assay proved that the cell viability decreased by 30.9% after being exposed to AMF for 2 h, while the cell viability decreased by 11.7% if spherical MNPs (sMNP, diameter of 200 +/- 50 nm) were used for investigation. Furthermore, the morphological effect of MNPs on cell viability was confirmed by trypan blue assay: 39.5% rMNP-loaded cells and 15.1% sMNP-loaded cells were stained after being exposed to AMF for 2 h. It was also interesting to find that killing tumor cells at either higher (500 mu g/mL) or lower (20 mu g/mL) concentration of MNPs was less efficient than that achieved at 100 mu g/mL concentration. In conclusion, the relatively asymmetric morphological rod-shaped MNPs can kill cancer cells more effectively than spherical MNPs when being exposed to AMF by virtue of their mechanical oscillations.
KeywordIron-oxide Nanoparticles Power Absorption Thermal Therapy Size Hyperthermia Toxicity Shape
Indexed BySCI
Language英语
WOS IDWOS:000336280900001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/14253
Collection中科院上海应用物理研究所2011-2019年
Corresponding Authorzhangguoxin@sinap.ac.cn; shi.hongcheng@zs-hospital.sh.cn
Recommended Citation
GB/T 7714
Cheng, DF,Li, X,Zhang, GX,et al. Morphological effect of oscillating magnetic nanoparticles in killing tumor cells[J]. NANOSCALE RESEARCH LETTERS,2014,9.
APA Cheng, DF,Li, X,Zhang, GX,Shi, HC,zhangguoxin@sinap.ac.cn,&shi.hongcheng@zs-hospital.sh.cn.(2014).Morphological effect of oscillating magnetic nanoparticles in killing tumor cells.NANOSCALE RESEARCH LETTERS,9.
MLA Cheng, DF,et al."Morphological effect of oscillating magnetic nanoparticles in killing tumor cells".NANOSCALE RESEARCH LETTERS 9(2014).
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