CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
NANOTOXICITY OF MULTIWALL CARBON NANOTUBES TO A549 CELLS IN VITRO
Wang, FD; Zhang, H; Jin, C; Liang, H; Tang, Y; Yang, YJ; chanjin1980@gmail.com
2014
Source PublicationNANO
ISSN1793-2920
Volume9Issue:2
AbstractMultiwall carbon nanotubes (MWCNTs) have been widely applied in many fields due to the excellent physical and chemical properties. As the production and applications of nanotubes expand, public concern about their potential risks to human health has also raised. Cytotoxicity of MWCNTs was evaluated in this study using a cultured human epithelial cell line A549. Uptake of MWCNTs by cultured A549 cells was observed by TEM imaging. Dose-dependent decrease of cell viability showed the cytotoxicity of MWCNTs. Significant reactive oxygen species (ROS) generation and GSH depletion which reduced the cellular antioxidant level could be the major factor of cytotoxicity induced by MWCNTs. MWCNTs seemed to trigger the activation of cell autophagy with the intracellular ATG16L1 level increase as a defense mechanism.
KeywordCerebral-ischemia Oxidative Stress Neuronal Death Generation Radicals
Indexed BySCI
Language英语
WOS IDWOS:000339000100016
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/14266
Collection中科院上海应用物理研究所2011-2019年
Corresponding Authorchanjin1980@gmail.com
Recommended Citation
GB/T 7714
Wang, FD,Zhang, H,Jin, C,et al. NANOTOXICITY OF MULTIWALL CARBON NANOTUBES TO A549 CELLS IN VITRO[J]. NANO,2014,9(2).
APA Wang, FD.,Zhang, H.,Jin, C.,Liang, H.,Tang, Y.,...&chanjin1980@gmail.com.(2014).NANOTOXICITY OF MULTIWALL CARBON NANOTUBES TO A549 CELLS IN VITRO.NANO,9(2).
MLA Wang, FD,et al."NANOTOXICITY OF MULTIWALL CARBON NANOTUBES TO A549 CELLS IN VITRO".NANO 9.2(2014).
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