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Pluronic-encapsulated natural chlorophyll nanocomposites for in vivo cancer imaging and photothermal/photodynamic therapies
Chu, MQ; Li, HK; Wu, Q; Wo, FJ; Shi, DL; mqchu98@tongji.edu.cn
2014
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume35Issue:29Pages:8357—8373
AbstractA great challenge in developing nanotechnologies for cancer diagnosis and therapy has been the combined functionalities required for complicated clinical procedures. Among all requirements, toxicity has been the major hurdle that has prevented most of the nano-carriers from clinical use. Here, we extracted chlorophyll (Chl) from vegetable and encapsulated it into polymer (pluronic F68, Plu) micelles for cancer imaging and therapy. The results showed that the Chl-containing nanocomposites were capable of mouse tumor targeting, and the nanocomposite fluorescence within the tumor sites remained at high intensity more than two days after tail-vein injection. It is interesting that oral administration with the nanocomposites was also successful for tumor target imaging. Furthermore, the dietary Chl was found to be able to efficiently convert near-infrared laser irradiation to heat. The growths of melanoma cells and mouse tumors were effectively inhibited after being treated with the nanocomposites and irradiation. The suppression of the tumors was achieved by laser-triggered photothermal and photodynamic synergistic effects of Chl. As a natural substance from vegetable, Chl is non-toxic, making it an ideal nano-carrier for cancer diagnosis and treatment. Based on the results of this research, the Plu-Chl nanocomposites have shown promise for future clinical applications. (C) 2014 Elsevier Ltd. All rights reserved.
KeywordPhotothermal Therapy Photodynamic Therapy Magnetic-resonance Graphene Oxide Gold Nanorods Melanoma Efficacy Nanoparticles Tumors Cells
Indexed BySCI
Language英语
WOS IDWOS:000340853400009
Citation statistics
Cited Times:37[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/14319
Collection中科院上海应用物理研究所2011-2019年
Corresponding Authormqchu98@tongji.edu.cn
Recommended Citation
GB/T 7714
Chu, MQ,Li, HK,Wu, Q,et al. Pluronic-encapsulated natural chlorophyll nanocomposites for in vivo cancer imaging and photothermal/photodynamic therapies[J]. BIOMATERIALS,2014,35(29):8357—8373.
APA Chu, MQ,Li, HK,Wu, Q,Wo, FJ,Shi, DL,&mqchu98@tongji.edu.cn.(2014).Pluronic-encapsulated natural chlorophyll nanocomposites for in vivo cancer imaging and photothermal/photodynamic therapies.BIOMATERIALS,35(29),8357—8373.
MLA Chu, MQ,et al."Pluronic-encapsulated natural chlorophyll nanocomposites for in vivo cancer imaging and photothermal/photodynamic therapies".BIOMATERIALS 35.29(2014):8357—8373.
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