Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| Rational Design of pH-Controlled DNA Strand Displacement | |
| Amodio, A; Zhao, B; Porchetta, A; Idili, A; Castronovo, M; Fan, CH; Ricci, F; francesco.ricci@uniroma2.it | |
| 2014 | |
| Source Publication | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
 |
| ISSN | 0002-7863 |
| Volume | 136Issue:47Pages:16469—16472 |
| Abstract | Achieving strategies to finely regulate with biological inputs the formation and functionality of DNA-based nanoarchitectures and nanomachines is essential toward a full realization of the potential of DNA nanotechnology. Here we demonstrate an unprecedented, rational approach to achieve control, through a simple change of the solutions pH, over an important class of DNA association-based reactions. To do so we took advantage of the pH dependence of parallel Hoogsteen interactions and rationally designed two triplex-based DNA strand displacement strategies that can be triggered and finely regulated at either basic or acidic pHs. Because pH change represents an important input both in healthy and pathological biological pathways, our findings can have implication for the development of DNA nanostructures whose assembly and functionality can be triggered in the presence of specific biological targets. |
| Keyword | Logic-circuits Nucleic-acids In-vitro Nanostructures Nanotechnology Nanoswitches Nanomachines Specificity Toeholds Devices |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000345720500003 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/14355 |
| Collection | 中科院上海应用物理研究所2011-2020年 |
| Corresponding Author | francesco.ricci@uniroma2.it |
| Recommended Citation GB/T 7714 | Amodio, A,Zhao, B,Porchetta, A,et al. Rational Design of pH-Controlled DNA Strand Displacement[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2014,136(47):16469—16472. |
| APA | Amodio, A.,Zhao, B.,Porchetta, A.,Idili, A.,Castronovo, M.,...&francesco.ricci@uniroma2.it.(2014).Rational Design of pH-Controlled DNA Strand Displacement.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,136(47),16469—16472. |
| MLA | Amodio, A,et al."Rational Design of pH-Controlled DNA Strand Displacement".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 136.47(2014):16469—16472. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Rational Design of p（684KB） | 开放获取 | CC BY-NC-SA | View Application Full Text | |||
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