CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Rational Design of pH-Controlled DNA Strand Displacement
Amodio, A; Zhao, B; Porchetta, A; Idili, A; Castronovo, M; Fan, CH; Ricci, F;
AbstractAchieving strategies to finely regulate with biological inputs the formation and functionality of DNA-based nanoarchitectures and nanomachines is essential toward a full realization of the potential of DNA nanotechnology. Here we demonstrate an unprecedented, rational approach to achieve control, through a simple change of the solutions pH, over an important class of DNA association-based reactions. To do so we took advantage of the pH dependence of parallel Hoogsteen interactions and rationally designed two triplex-based DNA strand displacement strategies that can be triggered and finely regulated at either basic or acidic pHs. Because pH change represents an important input both in healthy and pathological biological pathways, our findings can have implication for the development of DNA nanostructures whose assembly and functionality can be triggered in the presence of specific biological targets.
KeywordLogic-circuits Nucleic-acids In-vitro Nanostructures Nanotechnology Nanoswitches Nanomachines Specificity Toeholds Devices
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WOS IDWOS:000345720500003
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GB/T 7714
Amodio, A,Zhao, B,Porchetta, A,et al. Rational Design of pH-Controlled DNA Strand Displacement[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2014,136(47):16469—16472.
APA Amodio, A.,Zhao, B.,Porchetta, A.,Idili, A.,Castronovo, M.,...& Design of pH-Controlled DNA Strand Displacement.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,136(47),16469—16472.
MLA Amodio, A,et al."Rational Design of pH-Controlled DNA Strand Displacement".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 136.47(2014):16469—16472.
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