CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Release Behaviour of Single Pellets and Internal Fine 3D Structural Features Co-define the In Vitro Drug Release Profile
Yang, S; Yin, XZ; Wang, CF; Li, HY; He, Y; Xiao, TQ; Sun, LX; Li, JS; York, P; He, J; Zhang, JW; lijiasheng@wanhe-phar.com; P.York@Bradford.ac.uk; hejun1016@163.com; jwzhang@mail.shcnc.ac.cn
2014
Source PublicationAAPS JOURNAL
ISSN1550-7416
Volume16Issue:4Pages:860—871
AbstractMulti-pellet formulations are advantageous for the controlled release of drugs over single-unit dosage forms. To understand the diffusion controlled drug release mechanism, the pellet structure and drug release from a single pellet (not at dose level) were studied using synchrotron radiation X-ray computed microtomography (SR-mu CT) and a sensitive LC/MS/MS method. The purpose of this article is to introduce a powerful, non-invasive and quantitative technique for studying individual pellet microstructures and to investigate the relationship between the microstructure and drug release from single pellets. The data from the single pellet dissolution measurements demonstrated that the release profile of capsules containing approximately 1,000 pellets per unit dose was the summation of the release profiles of the individual pellets. The release profiles of single tamsulosin hydrochloride (TSH) pellets formed three groups when a cluster analysis was performed, and the dissolution rate of the individual pellets correlated well with the combined effects of the drug loading, volume and surface area of the pellets (R (2) = 0.9429). In addition, the void microstructures within the pellet were critical during drug release. Therefore, SR-mu CT is a powerful tool for quantitatively elucidating the three-dimensional microstructure of the individual pellets; because the microstructure controls drug release, it is an important parameter in the quality control of multi-pellet formulations.
KeywordMultiparticulate Systems Mechanism Interpretation Surface-area Soluble Drug Kinetics Microspheres Fundamentals Formulation Adsorption Simulation
Indexed BySCI
Language英语
WOS IDWOS:000338337400023
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/14362
Collection中科院上海应用物理研究所2011-2019年
Corresponding Authorlijiasheng@wanhe-phar.com; P.York@Bradford.ac.uk; hejun1016@163.com; jwzhang@mail.shcnc.ac.cn
Recommended Citation
GB/T 7714
Yang, S,Yin, XZ,Wang, CF,et al. Release Behaviour of Single Pellets and Internal Fine 3D Structural Features Co-define the In Vitro Drug Release Profile[J]. AAPS JOURNAL,2014,16(4):860—871.
APA Yang, S.,Yin, XZ.,Wang, CF.,Li, HY.,He, Y.,...&jwzhang@mail.shcnc.ac.cn.(2014).Release Behaviour of Single Pellets and Internal Fine 3D Structural Features Co-define the In Vitro Drug Release Profile.AAPS JOURNAL,16(4),860—871.
MLA Yang, S,et al."Release Behaviour of Single Pellets and Internal Fine 3D Structural Features Co-define the In Vitro Drug Release Profile".AAPS JOURNAL 16.4(2014):860—871.
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