CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Self-assembled polymeric micelles based on THP and THF linkage for pH-responsive drug delivery
Zhu, FX; Yang, QL; Zhuang, Y; Zhang, YQ; Shao, ZF; Gong, B; Shen, YM; bgong@buffalo.edu; yumeishen@sjtu.edu.cn
2014
Source PublicationPOLYMER
ISSN0032-3861
Volume55Issue:13Pages:2977—2985
AbstractDeveloping smart nanocarriers for drug delivery system is advantageous for many kinds of successful biomedicinal therapy. In this study, we designed an amphiphilic block copolymers containing pH-responsive tetrahydropyran (THP) and tetrahydrofuran (THF) linkage. Their structures were confirmed by H-1 NMR and gel permeation chromatography (GPC). The release rate of encapsulated drugs depends upon the pH value and pH sensitive linkage in the backbone of copolymers. For PLA THP PEG micelles the cumulative relea,se amount of doxorubicin (DOX) was 62% at pH 5.0, which is about four times higher than that at pH 7.4. Under the same conditions the release rate for PLA THF PEG micelles is a little faster than that of the PLA THP PEG micelles. Cellular uptake study demonstrates that DOX-loaded micelles can easily enter the cells and produce the desired pharmacological action and minimizing the side effect of free DOX. These findings indicate that THP and THF linked diblock copolymer micelles is a promising candidate for drug carrier. (C) 2014 Elsevier Ltd. All rights reserved.
KeywordBlock-copolymer Micelles Intracellular Delivery Anticancer Drug Release Nanocarriers Doxorubicin Design Acid Micellization Nanoparticles
Indexed BySCI
Language英语
WOS IDWOS:000337549000006
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/14377
Collection中科院上海应用物理研究所2011-2019年
Corresponding Authorbgong@buffalo.edu; yumeishen@sjtu.edu.cn
Recommended Citation
GB/T 7714
Zhu, FX,Yang, QL,Zhuang, Y,et al. Self-assembled polymeric micelles based on THP and THF linkage for pH-responsive drug delivery[J]. POLYMER,2014,55(13):2977—2985.
APA Zhu, FX.,Yang, QL.,Zhuang, Y.,Zhang, YQ.,Shao, ZF.,...&yumeishen@sjtu.edu.cn.(2014).Self-assembled polymeric micelles based on THP and THF linkage for pH-responsive drug delivery.POLYMER,55(13),2977—2985.
MLA Zhu, FX,et al."Self-assembled polymeric micelles based on THP and THF linkage for pH-responsive drug delivery".POLYMER 55.13(2014):2977—2985.
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