CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Three dimensional visualization of engineered bone and soft tissue by combined x-ray micro-diffraction and phase contrast tomography
Cedola, A; Campi, G; Pelliccia, D; Bukreeva, I; Fratini, M; Burghammer, M; Rigon, L; Arfelli, F; Chen, RC; Dreossi, D; Sodini, N; Mohammadi, S; Tromba, G; Cancedda, R; Mastrogiacomo, M; alessia.cedola@cnr.it; gaetano.campi@ic.cnr.it
2014
Source PublicationPHYSICS IN MEDICINE AND BIOLOGY
ISSN0031-9155
Volume59Issue:1Pages:189—201
AbstractComputed x-ray phase contrast micro-tomography is the most valuable tool for a three dimensional (3D) and non destructive analysis of the tissue engineered bone morphology. We used a Talbot interferometer installed at SYRMEP beamline of the ELETTRA synchrotron (Trieste, Italy) for a precise 3D reconstruction of both bone and soft connective tissue, regenerated in vivo within a porous scaffold. For the first time the x-ray tomographic reconstructions have been combined with x-ray scanning micro-diffraction measurement on the same sample, in order to give an exhaustive identification of the different tissues participating to the biomineralization process. As a result, we were able to investigate in detail the different densities in the tissues, distinguishing the 3D organization of the amorphous calcium phosphate from the collagen matrix. Our experimental approach allows for a deeper understanding of the role of collagen matrix in the organic-mineral transition, which is a crucial issue for the development of new bio-inspired composites.
KeywordMarrow Stromal Cells Synchrotron-radiation Calcium-phosphate Microdiffraction Interferometer Orientation Brilliance Gratings Kinetics Collagen
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/14508
Collection中科院上海应用物理研究所2011-2020年
Corresponding Authoralessia.cedola@cnr.it; gaetano.campi@ic.cnr.it
Recommended Citation
GB/T 7714
Cedola, A,Campi, G,Pelliccia, D,et al. Three dimensional visualization of engineered bone and soft tissue by combined x-ray micro-diffraction and phase contrast tomography[J]. PHYSICS IN MEDICINE AND BIOLOGY,2014,59(1):189—201.
APA Cedola, A.,Campi, G.,Pelliccia, D.,Bukreeva, I.,Fratini, M.,...&gaetano.campi@ic.cnr.it.(2014).Three dimensional visualization of engineered bone and soft tissue by combined x-ray micro-diffraction and phase contrast tomography.PHYSICS IN MEDICINE AND BIOLOGY,59(1),189—201.
MLA Cedola, A,et al."Three dimensional visualization of engineered bone and soft tissue by combined x-ray micro-diffraction and phase contrast tomography".PHYSICS IN MEDICINE AND BIOLOGY 59.1(2014):189—201.
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