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Tissue engineering scaffolds of mesoporous magnesium silicate and poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) composite
He, DW; Dong, W; Tang, SC; Wei, J; Liu, ZH; Gu, XJ; Li, M; Guo, H; Niu, YF; biomaterbone@163.com; niuy1111@163.com
2014
Source PublicationJOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
ISSN0957-4530
Volume25Issue:6Pages:1415—1424
AbstractMesoporous magnesium silicate (m-MS) and poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) (PCL-PEG-PCL) composite scaffolds were fabricated by solvent-casting and particulate leaching method. The results suggested that the incorporation of m-MS into PCL-PEG-PCL could significantly improve the water adsorption of the m-MS/PCL-PEG-PCL composite (m-MPC) scaffolds. The in vitro degradation behavior of m-MPC scaffolds were determined by testing weight loss of the scaffolds after soaking into phosphate buffered saline (PBS), and the result showed that the degradation of m-MPC scaffolds was obviously enhanced by addition of m-MS into PCL-PEG-PCL after soaking for 10 weeks. Proliferation of MG63 cells on m-MPC was significantly higher than MPC scaffolds at 4 and 7 days. ALP activity on the m-MPC was obviously higher than MPC scaffolds at 7 days, revealing that m-MPC could promote cell differentiation. Histological evaluation showed that the introduction of m-MS into PCL-PEG-PCL enhanced the efficiency of new bone formation when the m-MPC scaffolds implanted into bone defect of rabbits. The results suggested that the inorganic/organic composite of m-MS and PCL-PEG-PCL scaffolds exhibited good biocompatibility, degradability and osteogenesis.
KeywordBioactive Glass Scaffolds Bone Regeneration Drug-delivery Differentiation Proliferation Hydrogel Surfaces Adhesion Matrix
Indexed BySCI
Language英语
WOS IDWOS:000336904200003
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/14515
Collection中科院上海应用物理研究所2011-2020年
Corresponding Authorbiomaterbone@163.com; niuy1111@163.com
Recommended Citation
GB/T 7714
He, DW,Dong, W,Tang, SC,et al. Tissue engineering scaffolds of mesoporous magnesium silicate and poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) composite[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2014,25(6):1415—1424.
APA He, DW.,Dong, W.,Tang, SC.,Wei, J.,Liu, ZH.,...&niuy1111@163.com.(2014).Tissue engineering scaffolds of mesoporous magnesium silicate and poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) composite.JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,25(6),1415—1424.
MLA He, DW,et al."Tissue engineering scaffolds of mesoporous magnesium silicate and poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) composite".JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 25.6(2014):1415—1424.
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