CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Tryptamine functionalized reduced graphene oxide for label-free DNA impedimetric biosensing
Zhang, Z; Luo, LQ; Chen, GF; Ding, YP; Deng, DM; Fan, CH; luck@shu.edu.cn
2014
Source PublicationBIOSENSORS & BIOELECTRONICS
ISSN0956-5663
Volume60Pages:161—166
AbstractA novel simple protocol of synthesizing tryptamine-functionalized reduced graphene oxide (TRA-rGO) was proposed to fabricate label-free electrochemical impedance DNA biosensor. TRA was anchored to rGO with its indole ring via pi-stacking interaction. The morphology, conductivity and interaction of TRA-rGO were characterized by atomic force microscopy, high resolution transmission electron microscopy, cyclic voltammetry, electrochemical impedance spectroscopy (EIS) as well as Raman and fluorescence spectroscopy. The amino-substituted oligonucleotide probe was conjugated to TRA by cross-linker glutaraldehyde for preparing an electrochemical biosensing platform. The DNA hybridization reaction of oligonucleotide probe with target DNA was monitored by EIS. Under optimum conditions, the proposed biosensor exhibited high sensitivity and low detection limit for detecting complementary oligonucleotide. The target oligonucleotide could be quantified in a wide range of 1.0 x 10(-12)-1.0 x 10(-7) M with low detection limit of 5.2 x 10(-13) M (S/N=3). (C) 2014 Elsevier B.V. All rights reserved.
KeywordElectrochemical Biosensor Hybrid Materials Nanocomposites Graphite Sheets Films Amplification Exfoliation Composites Microscopy
Indexed BySCI
Language英语
WOS IDWOS:000337863900022
Citation statistics
Cited Times:25[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/14530
Collection中科院上海应用物理研究所2011-2019年
Corresponding Authorluck@shu.edu.cn
Recommended Citation
GB/T 7714
Zhang, Z,Luo, LQ,Chen, GF,et al. Tryptamine functionalized reduced graphene oxide for label-free DNA impedimetric biosensing[J]. BIOSENSORS & BIOELECTRONICS,2014,60:161—166.
APA Zhang, Z.,Luo, LQ.,Chen, GF.,Ding, YP.,Deng, DM.,...&luck@shu.edu.cn.(2014).Tryptamine functionalized reduced graphene oxide for label-free DNA impedimetric biosensing.BIOSENSORS & BIOELECTRONICS,60,161—166.
MLA Zhang, Z,et al."Tryptamine functionalized reduced graphene oxide for label-free DNA impedimetric biosensing".BIOSENSORS & BIOELECTRONICS 60(2014):161—166.
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