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| Uniform Small Graphene Oxide as an Efficient Cellular Nanocarrier for Immunostimulatory CpG Oligonucleotides | |
| Sun, JL; Chao, J; Huang, J; Yin, M; Zhang, H; Peng, C; Zhong, ZT; Chen, N; ztzhong@njau.edu.cn; chennan@sinap.ac.cn | |
| 2014 | |
| Source Publication | ACS APPLIED MATERIALS & INTERFACES
 |
| ISSN | 1944-8244 |
| Volume | 6Issue:10Pages:7926—7932 |
| Abstract | Graphene oxide (GO) has attracted more and more attention as a promising nanomaterial in biomedical research and applications. In this study, we explore the ability of GO as nanocarrier for synthetic DNA strands. Immunostimulatory CpG oligodeoxynucleotides (ODNs) are attached to Poly-L-Lysine (PLL) functionalized, polydisperse GO, or uniform small GO (sGO) nanosheets. Both types of GO-CpG ODN nanoconjugates can be delivered into murine Raw264.7 macrophages and possess immunostimulatory activity, while sGO-CpG appears to be a more efficient stimulator. In addition, sGO-CpG nanosheets exhibit higher cellular uptake but better biocompatibility compared to the larger GO-CpG counterpart. Furthermore, PLL functionalized sGO-CpG has higher immunostimulatory activity than azide functionalized sGO-CpG. Together, our studies provide evidence that sGO can be utilized as an ideal intracellular nanocarrier for synthetic single-stranded DNA, and sGO-PLL-CpG conjugates may serve as a potential proinflammatory therapeutic tool. |
| Keyword | Biomedical Applications Dna Nanostructures Drug-delivery Bacterial-dna Oligodeoxynucleotides Cells Odn Nanoparticles Therapeutics Activation |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000336639200115 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/14540 |
| Collection | 中科院上海应用物理研究所2011-2020年 |
| Corresponding Author | ztzhong@njau.edu.cn; chennan@sinap.ac.cn |
| Recommended Citation GB/T 7714 | Sun, JL,Chao, J,Huang, J,et al. Uniform Small Graphene Oxide as an Efficient Cellular Nanocarrier for Immunostimulatory CpG Oligonucleotides[J]. ACS APPLIED MATERIALS & INTERFACES,2014,6(10):7926—7932. |
| APA | Sun, JL.,Chao, J.,Huang, J.,Yin, M.,Zhang, H.,...&chennan@sinap.ac.cn.(2014).Uniform Small Graphene Oxide as an Efficient Cellular Nanocarrier for Immunostimulatory CpG Oligonucleotides.ACS APPLIED MATERIALS & INTERFACES,6(10),7926—7932. |
| MLA | Sun, JL,et al."Uniform Small Graphene Oxide as an Efficient Cellular Nanocarrier for Immunostimulatory CpG Oligonucleotides".ACS APPLIED MATERIALS & INTERFACES 6.10(2014):7926—7932. |
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| Uniform Small Graphe（4383KB） | 开放获取 | CC BY-NC-SA | View Download | |||
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