CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Using Xe as a heavy atom for phase determination of protein trichosanthin structure
Chen, YX; Li, MJ; Yu, F; Liu, K; Xu, CY; Sun, B; Zhou, H; Xu, Q; He, JH; liminjun@sinap.ac.cn; hejh@sinap.ac.cn
2014
Source PublicationNUCLEAR SCIENCE AND TECHNIQUES
ISSN1001-8042
Volume25Issue:3
AbstractUnder gas pressures of 1-3 MPa, xenon can be bound to discrete sites in hydrophobic cavities of protein, so as to use Xe as a heavy atom for determining phases in protein crystallography. Using single anomalous scattering diffraction method, we demonstrate that an interpretable electron density map can be obtained for protein trichosanthin from a single xenon derivative. We found, for the first time, a pre-existing hydrophobic cavity just under the protein surface of trichosanthin.
KeywordRibosome-inactivating Protein Angstrom Resolution Crystal-structure Binding Xenon Alpha Channels Reveals History Complex
Indexed BySCI
Language英语
WOS IDWOS:000339366300013
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/14546
Collection中科院上海应用物理研究所2011-2019年
Corresponding Authorliminjun@sinap.ac.cn; hejh@sinap.ac.cn
Recommended Citation
GB/T 7714
Chen, YX,Li, MJ,Yu, F,et al. Using Xe as a heavy atom for phase determination of protein trichosanthin structure[J]. NUCLEAR SCIENCE AND TECHNIQUES,2014,25(3).
APA Chen, YX.,Li, MJ.,Yu, F.,Liu, K.,Xu, CY.,...&hejh@sinap.ac.cn.(2014).Using Xe as a heavy atom for phase determination of protein trichosanthin structure.NUCLEAR SCIENCE AND TECHNIQUES,25(3).
MLA Chen, YX,et al."Using Xe as a heavy atom for phase determination of protein trichosanthin structure".NUCLEAR SCIENCE AND TECHNIQUES 25.3(2014).
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