CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
A Comparative Study on the Self-Assembly of an Amyloid-Like Peptide at Water-Solid Interfaces and in Bulk Solutions
Du, QQG; Dai, B; Hou, JH; Hu, J; Zhang, F; Zhang, Y
2015
Source PublicationMICROSCOPY RESEARCH AND TECHNIQUE
Volume78Issue:5Pages:375—381
Subtype期刊文献
AbstractIn the past years the self-assembly of amyloid-like peptides has attracted increasing attentions, because it is highly related to neurodegenerative diseases and has a potential for serving as nanomaterial to fabricate novel and useful nanostructures. In this paper, we focused on the role of interfacial conditions in the self-assembly of an amyloid-like peptide, termed Pep11. It was found that, when dissolved in bulk solutions, Pep11 formed into -sheet structures and assembled into long filaments in several hours, as revealed by Thioflavin T fluorescence and transmission electron microscopy (TEM) morphology characterization, respectively. When the peptide solution was added onto a mica/HOPG substrate, peptide filaments with three preferred orientations with an angle of 60 degrees to each other were formed immediately, as imaged in situ by atomic force microscopy (AFM). However, the kinetics in filament formation and the morphologies of the formed beta sheet either on HOPG and mica or in bulk solutions were quite different. These results indicate that the interfacial properties dramatically affect the peptide self-assembly process. Microsc. Res. Tech. 78:375-381, 2015. (c) 2015 Wiley Periodicals, Inc.
KeywordAtomic-force Microscopy Beta-sheet Tapes Nanofiber Scaffold Fibril Formation Alpha-synuclein Nanotubes Protein Nanofilaments Mechanism Surfaces
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/24369
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Du, QQG,Dai, B,Hou, JH,et al. A Comparative Study on the Self-Assembly of an Amyloid-Like Peptide at Water-Solid Interfaces and in Bulk Solutions[J]. MICROSCOPY RESEARCH AND TECHNIQUE,2015,78(5):375—381.
APA Du, QQG,Dai, B,Hou, JH,Hu, J,Zhang, F,&Zhang, Y.(2015).A Comparative Study on the Self-Assembly of an Amyloid-Like Peptide at Water-Solid Interfaces and in Bulk Solutions.MICROSCOPY RESEARCH AND TECHNIQUE,78(5),375—381.
MLA Du, QQG,et al."A Comparative Study on the Self-Assembly of an Amyloid-Like Peptide at Water-Solid Interfaces and in Bulk Solutions".MICROSCOPY RESEARCH AND TECHNIQUE 78.5(2015):375—381.
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