CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
A MoS2-based system for efficient immobilization of hemoglobin and biosensing applications
Chao, J; Zou, M; Zhang, C; Sun, HF; Pan, D; Pei, H; Su, S; Yuwen, LH; Fan, CH; Wang, LH
2015
Source PublicationNANOTECHNOLOGY
Volume26Issue:27Pages:
Subtype期刊文献
AbstractA novel hydrogen peroxide (H2O2) and nitric oxide (NO) biosensor was fabricated by immobilizing hemoglobin (Hb) on a gold nanoparticle-decorated MoS2 nanosheet (AuNPs@MoS2) nanocomposite film modified glass carbon electrode. The AuNPs@MoS2 nanocomposite not only made the immobilized Hb keep its native biological activity but also facilitated the electron transfer between electrode and the electroactive center of Hb due to its excellent conductivity and biocompatibility. The direct electrochemistry and bioelectrocatalytic activity of Hb were investigated by cyclic voltammetry (CV). The modified electrode showed good electrocatalytic ability toward the reduction of H2O2 and NO. Under optimal conditions, the current response was linear with the concentration of H2O2 and NO in the range from 10 to 300 mu M and 10 to 1100 mu M with a detection limit of 4 and 5 mu M, respectively. This MoS2-based biosensor was sensitive, reproducible and stable, indicating that AuNPs@MoS2 nanocomposite maybe a promising platform to construct electrochemical sensors for chemical and biological molecules detection.
KeywordMolybdenum-disulfide Nanosheets Direct Electron-transfer Glassy-carbon Electrode Single-layer Mos2 Hydrogen-peroxide Nitric-oxide Direct Electrochemistry Horseradish-peroxidase Catalytic-activity Au Nanoparticles
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/24373
Collection中科院上海应用物理研究所2011-2020年
Recommended Citation
GB/T 7714
Chao, J,Zou, M,Zhang, C,et al. A MoS2-based system for efficient immobilization of hemoglobin and biosensing applications[J]. NANOTECHNOLOGY,2015,26(27):—.
APA Chao, J.,Zou, M.,Zhang, C.,Sun, HF.,Pan, D.,...&Wang, LH.(2015).A MoS2-based system for efficient immobilization of hemoglobin and biosensing applications.NANOTECHNOLOGY,26(27),—.
MLA Chao, J,et al."A MoS2-based system for efficient immobilization of hemoglobin and biosensing applications".NANOTECHNOLOGY 26.27(2015):—.
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