CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Bioactive and degradable scaffolds of the mesoporous bioglass and poly(L-lactide) composite for bone tissue regeneration
Niu, YF; Guo, LP; Liu, J; Shen, HX; Su, JC; An, XF; Yu, BQ; Wei, J; Shin, JW; Guo, H; Ji, F; He, DW
2015
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
Volume3Issue:15Pages:2962—2970
Subtype期刊文献
AbstractBioactive scaffolds of the mesoporous bioglass (m-BG) and poly(L-lactide) (PLLA) composite were fabricated using a solvent casting-particulate leaching method. The results showed that incorporation of the m-BG into PLLA significantly improved the in vitro water absorption, degradability and apatite-formation ability of the m-BG-PLLA composite scaffolds, which were m-BG content dependent. Moreover, addition of the m-BG into PLLA could neutralize the acidic degradation products of PLLA and thus compensate for the decrease of the pH value. In cell culture experiments, the results revealed that the m-BG-PLLA composite scaffolds enhanced attachment, proliferation and alkaline phosphatase (ALP) activity of MC3T3-E1 cells, which were m-BG content dependent. In animal experiments, the SRmCT and histological elevation results showed that the composite scaffolds significantly improved osteogenesis in vivo. It can be suggested that incorporation of bioactive materials of m-BG into PLLA was a useful approach to obtain composite scaffolds with improved properties (such as water absorption, degradability, bioactivity and osteogenesis), and the composite scaffolds with excellent biocompatibility could be promising bioactive implants for bone regeneration.
KeywordGlass Submicron Spheres Poly-l-lactide Biological-properties Hydroxyapatite Biomaterials Magnesium Cells Poly(Epsilon-caprolactone) Polycaprolactone Differentiation
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/24401
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Niu, YF,Guo, LP,Liu, J,et al. Bioactive and degradable scaffolds of the mesoporous bioglass and poly(L-lactide) composite for bone tissue regeneration[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(15):2962—2970.
APA Niu, YF.,Guo, LP.,Liu, J.,Shen, HX.,Su, JC.,...&He, DW.(2015).Bioactive and degradable scaffolds of the mesoporous bioglass and poly(L-lactide) composite for bone tissue regeneration.JOURNAL OF MATERIALS CHEMISTRY B,3(15),2962—2970.
MLA Niu, YF,et al."Bioactive and degradable scaffolds of the mesoporous bioglass and poly(L-lactide) composite for bone tissue regeneration".JOURNAL OF MATERIALS CHEMISTRY B 3.15(2015):2962—2970.
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