CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Development of functional in vivo imaging of cerebral lenticulostriate artery using novel synchrotron radiation angiography
Lin, XJ; Miao, P; Mu, ZH; Jiang, Z; Lu, YF; Guan, YJ; Chen, XY; Xiao, TQ; Wang, YT; Yang, GY
2015
Source PublicationPHYSICS IN MEDICINE AND BIOLOGY
Volume60Issue:4Pages:1655—1665
Subtype期刊文献
AbstractThe lenticulostriate artery plays a vital role in the onset and development of cerebral ischemia. However, current imaging techniques cannot assess the in vivo functioning of small arteries such as the lenticulostriate artery in the brain of rats. Here, we report a novel method to achieve a high resolution multi-functional imaging of the cerebrovascular system using synchrotron radiation angiography, which is based on spatio-temporal analysis of contrast density in the arterial cross section. This method provides a unique tool for studying the sub-cortical vascular elasticity after cerebral ischemia in rats. Using this technique, we demonstrated that the vascular elasticity of the lenticulostriate artery decreased from day 1 to day 7 after transient middle cerebral artery occlusion in rats and recovered from day 7 to day 28 compared to the controls (p < 0.001), which paralleled with brain edema formation and inversely correlated with blood flow velocity (p < 0.05). Our results demonstrated that the change of vascular elasticity was related to the levels of brain edema and the velocity of focal blood flow, suggesting that reducing brain edema is important for the improvement of the function of the lenticulostriate artery in the ischemic brain.
KeywordBlood-flow Vascular Function Brain Ischemia Angiogenesis Volume Rats
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/24427
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Lin, XJ,Miao, P,Mu, ZH,et al. Development of functional in vivo imaging of cerebral lenticulostriate artery using novel synchrotron radiation angiography[J]. PHYSICS IN MEDICINE AND BIOLOGY,2015,60(4):1655—1665.
APA Lin, XJ.,Miao, P.,Mu, ZH.,Jiang, Z.,Lu, YF.,...&Yang, GY.(2015).Development of functional in vivo imaging of cerebral lenticulostriate artery using novel synchrotron radiation angiography.PHYSICS IN MEDICINE AND BIOLOGY,60(4),1655—1665.
MLA Lin, XJ,et al."Development of functional in vivo imaging of cerebral lenticulostriate artery using novel synchrotron radiation angiography".PHYSICS IN MEDICINE AND BIOLOGY 60.4(2015):1655—1665.
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