CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Graphene Oxide-Assisted Nucleic Acids Assays Using Conjugated Polyelectrolytes-Based Fluorescent Signal Transduction
Li, F; Chao, J; Li, ZH; Xing, S; Su, S; Li, XX; Song, SP; Zuo, XL; Fan, CH; Liu, B; Huang, W; Wang, LH; Wang, LH
2015
Source PublicationANALYTICAL CHEMISTRY
Volume87Issue:7Pages:3877—3883
Subtype期刊文献
AbstractIn this work, we investigated the interactions between graphene oxide (GO) and conjugated polyelectrolytes (CPEs) with different backbone and side chain structures. By studying the mechanism of fluorescence quenching of CPEs by GO, we find that the charge and the molecular structure of CPEs play important roles for GO-CPEs interactions. Among them, electrostatic interaction, pi-pi interaction, and cation-pi bonding are dominant driving forces. By using a cationic P2, we have developed a sensitive homogeneous sensor for DNA and RNA detection with a detection limit of 50 pM DNA and RNA, which increased the sensitivity by 40-fold as compared to GO-free CPE-based sensors. This GO-assisted CPE sensing strategy is also generic and shows a high potential for biosensor designs based on aptamers, proteins, peptides, and other biological probes
KeywordPolymer Complexes Dna Cancer Micrornas Adsorption Biomarkers Biosensors Proteins Binding Cells
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/24465
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Li, F,Chao, J,Li, ZH,et al. Graphene Oxide-Assisted Nucleic Acids Assays Using Conjugated Polyelectrolytes-Based Fluorescent Signal Transduction[J]. ANALYTICAL CHEMISTRY,2015,87(7):3877—3883.
APA Li, F.,Chao, J.,Li, ZH.,Xing, S.,Su, S.,...&Wang, LH.(2015).Graphene Oxide-Assisted Nucleic Acids Assays Using Conjugated Polyelectrolytes-Based Fluorescent Signal Transduction.ANALYTICAL CHEMISTRY,87(7),3877—3883.
MLA Li, F,et al."Graphene Oxide-Assisted Nucleic Acids Assays Using Conjugated Polyelectrolytes-Based Fluorescent Signal Transduction".ANALYTICAL CHEMISTRY 87.7(2015):3877—3883.
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