CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Growth and Origami Folding of DNA on Nanoparticles for High-Efficiency Molecular Transport in Cellular Imaging and Drug Delivery
Yan, J; Hu, CY; Wang, P; Zhao, B; Ouyang, XY; Zhou, J; Liu, R; He, DN; Fan, CH; Song, SP
2015
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume54Issue:8Pages:2431—2435
Subtype期刊文献
AbstractA novel three-dimensional (3D) superstructure based on the growth and origami folding of DNA on gold nanoparticles (AuNPs) was developed. The 3D superstructure contains a nanoparticle core and dozens of two-dimensional DNA belts folded from long single-stranded DNAs grown insitu on the nanoparticle by rolling circle amplification (RCA). We designed two mechanisms to achieve the loading of molecules onto the 3D superstructures. In one mechanism, ligands bound to target molecules are merged into the growing DNA during the RCA process (merging mechanism). In the other mechanism, target molecules are intercalated into the double-stranded DNAs produced by origami folding (intercalating mechanism). We demonstrated that the as-fabricated 3D superstructures have a high molecule-loading capacity and that they enable the high-efficiency transport of signal reporters and drugs for cellular imaging and drug delivery, respectively.
KeywordRolling Circle Amplification Quantum Dots Gold Nanoparticles Biomedical Applications Intracellular Delivery Living Cells Peptides Carrier Nanostructures Diagnostics
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/24467
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Yan, J,Hu, CY,Wang, P,et al. Growth and Origami Folding of DNA on Nanoparticles for High-Efficiency Molecular Transport in Cellular Imaging and Drug Delivery[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2015,54(8):2431—2435.
APA Yan, J.,Hu, CY.,Wang, P.,Zhao, B.,Ouyang, XY.,...&Song, SP.(2015).Growth and Origami Folding of DNA on Nanoparticles for High-Efficiency Molecular Transport in Cellular Imaging and Drug Delivery.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,54(8),2431—2435.
MLA Yan, J,et al."Growth and Origami Folding of DNA on Nanoparticles for High-Efficiency Molecular Transport in Cellular Imaging and Drug Delivery".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 54.8(2015):2431—2435.
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