|Photochemical properties of gemifloxacin: A laser flash photolysis study|
|Xu, YL; Liu, YC; Zhao, JF; Li, HX; Zhang, P; Wang, WF
|Source Publication||JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
|Abstract||The photochemical properties of gemifloxacin (GEFX), a fluoroquinolone antibacterial drug that exhibits phototoxicity toward biological substrates, were studied in aqueous solutions by laser flash photolysis (LFP) and pulse radiolysis. GEFX triplet state ((3)GEFX*) absorption spectra showed maximum absorption at 510 nm. (3)GEFX* was quenched by naproxen (NAP) via energy transfer with a rate constant of 1.2 x 10(8) dm(3) mol(-1) s(-1). The energy of (3)GEFX* was 266 kJ mol(-1) and the transient absorption spectra showed direct evidence of electron transfer from 2'-deoxyguanosine-5'-monophosphate, N,N,N',N'-tetramethyl-p-phenylenediamine, and tryptophan to (3)GEFX* with bimolecular reaction rate constants of 4.1 x 10(6), 2.0 x 10(7), and 2.2 x 10(7) dm(3) mo1(-1) s(-1), respectively. The rate constants for reactions of GEFX with 'OH, ea, were found to be 1.5 x 10(10) and 1.4 x 10(10) dm(3) mol(-1) s(-1), respectively. The mechanisms and products of the photosensitive damage of lysozyme were related to the GEFX concentration, irradiation time, and ambient conditions. (C) 2014 Elsevier B.V. All rights reserved.|
Triplet State Energy
Xu, YL,Liu, YC,Zhao, JF,et al. Photochemical properties of gemifloxacin: A laser flash photolysis study[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,2015,143:30—37.
Xu, YL,Liu, YC,Zhao, JF,Li, HX,Zhang, P,&Wang, WF.(2015).Photochemical properties of gemifloxacin: A laser flash photolysis study.JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,143,30—37.
Xu, YL,et al."Photochemical properties of gemifloxacin: A laser flash photolysis study".JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 143(2015):30—37.
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