CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Photosensitive damage of lysozyme caused by pazufloxacin and the protective effect of ferulic acid
Xu, YL; Liu, YC; Li, HX; Zhang, P; Zhao, JF; Wang, WF
2015
Source PublicationSCIENCE CHINA-CHEMISTRY
Volume58Issue:3Pages:508—513
Subtype期刊文献
AbstractLaser flash photolysis and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) experiments were carried out to study the photosensitive damage induced by pazufloxacin (PAX) and the protection of lysozyme (Lyso) by ferulic acid (FCA), an active antioxidant. Transient absorption spectra revealed electron transfer from Lyso and FCA to (3)PAX*, with respective bimolecular reaction rate constants of 6.3x10(7) and 1.4x10(10) dm(3)/(mol s). A pulse radiolysis study was also performed to investigate the formation of Lyso radical cations. Results showed that FCA effectively inhibits the cross-linking of protein induced by fluoroquinolones. Finally, a mechanism of the protective effect of FCA on Lyso was proposed.
KeywordPulse-radiolysis Aqueous-solution In-vitro Dna-damage Ciprofloxacin Fluoroquinolones Phototoxicity Quinolones Oxidation Vivo
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/24533
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Xu, YL,Liu, YC,Li, HX,et al. Photosensitive damage of lysozyme caused by pazufloxacin and the protective effect of ferulic acid[J]. SCIENCE CHINA-CHEMISTRY,2015,58(3):508—513.
APA Xu, YL,Liu, YC,Li, HX,Zhang, P,Zhao, JF,&Wang, WF.(2015).Photosensitive damage of lysozyme caused by pazufloxacin and the protective effect of ferulic acid.SCIENCE CHINA-CHEMISTRY,58(3),508—513.
MLA Xu, YL,et al."Photosensitive damage of lysozyme caused by pazufloxacin and the protective effect of ferulic acid".SCIENCE CHINA-CHEMISTRY 58.3(2015):508—513.
Files in This Item: Download All
File Name/Size DocType Version Access License
Photosensitive damag(950KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xu, YL]'s Articles
[Liu, YC]'s Articles
[Li, HX]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xu, YL]'s Articles
[Liu, YC]'s Articles
[Li, HX]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xu, YL]'s Articles
[Liu, YC]'s Articles
[Li, HX]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Photosensitive damage of lysozyme caused by pazufloxacin and the protective effect of ferulic acid.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.