CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Rare Earth Core/Shell Nanobarcodes for Multiplexed Trace Biodetection
Chen, L; Li, XM; Shen, DK; Zhou, L; Zhu, D; Fan, CH; Zhang, F
AbstractMultiplexed detection technology has been attractive for its simultaneous assay of several analytes, which play significant roles in applications such as Screening for combinatorial chemistry, genetic analysis, and clinical diagnostics. This work reports a novel and potentially powerful encoding system based upon dispersible suspension arrays of multilayer rare earth core/shell nanoparticles that are capable of multiplexed, high-sensitivity reporting for biomolecule detection by the Z-contrast imaging. These nanobarcode arrays are encoded by nanostructure design based on different atomic numbers. With the Well-resolved high-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM) decoding technique, many thousands of unique nanobarcodes can be identified by multilayer core/shell nanostructure. Their applications to multiplexed biodetection of DNA demonstrated the highly sensitive (picomole) features of this novel nanobarcode system.
KeywordUp-conversion Nanoparticles Dna Functionalization Technology Microbeads Particles Contrast Strategy Barcodes Growth
Indexed BySCI
Document Type期刊论文
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GB/T 7714
Chen, L,Li, XM,Shen, DK,et al. Rare Earth Core/Shell Nanobarcodes for Multiplexed Trace Biodetection[J]. ANALYTICAL CHEMISTRY,2015,87(11):5745—5752.
APA Chen, L.,Li, XM.,Shen, DK.,Zhou, L.,Zhu, D.,...&Zhang, F.(2015).Rare Earth Core/Shell Nanobarcodes for Multiplexed Trace Biodetection.ANALYTICAL CHEMISTRY,87(11),5745—5752.
MLA Chen, L,et al."Rare Earth Core/Shell Nanobarcodes for Multiplexed Trace Biodetection".ANALYTICAL CHEMISTRY 87.11(2015):5745—5752.
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