CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier
Dai, B; Li, D; Xi, W; Luo, F; Zhang, X; Zou, M; Cao, M; Hu, J; Wang, WY; Wei, GH; Zhang, Y; Liu, C
2015
Source PublicationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume112Issue:10Pages:2996—3001
Subtype期刊文献
AbstractUsing and engineering amyloid as nanomaterials are blossoming trends in bionanotechnology. Here, we show our discovery of an amyloid structure, termed "amyloid-like nanosheet," formed by a key amyloid-forming segment of Alzheimer's A beta. Combining multiple biophysical and computational approaches, we proposed a structural model for the nanosheet that is formed by stacking the amyloid fibril spines perpendicular to the fibril axis. We further used the nanosheet for laboratorial retroviral transduction enhancement and directly visualized the presence of virus on the nanosheet surface by electron microscopy. Furthermore, based on our structural model, we designed nanosheet-forming peptides with different functionalities, elucidating the potential of rational design for amyloid-based materials with novel architecture and function.
KeywordBuilding-blocks Fibrils Proteins Nanotubes Disease Nanomaterials Design
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/24613
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Dai, B,Li, D,Xi, W,et al. Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2015,112(10):2996—3001.
APA Dai, B.,Li, D.,Xi, W.,Luo, F.,Zhang, X.,...&Liu, C.(2015).Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,112(10),2996—3001.
MLA Dai, B,et al."Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112.10(2015):2996—3001.
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