CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Application of Carbon Nanomaterials in Gene Delivery for Endogenous RNA Interference In Vitro and In Vivo
Li, LY; Wen, YL; Xu, Q; Xu, L; Liu, D; Liu, G; Huang, Q; Liu, G (reprint author), Shanghai Inst Measurement & Testing Technol, Shanghai 201800, Peoples R China.
2015
Source PublicationCURRENT PHARMACEUTICAL DESIGN
ISSN1381-6128
Volume21Issue:22Pages:3191—3198
Subtype期刊文献
AbstractKnocking down expression by small interfering RNA (siRNA) has shown high affinity, specificity and potency in silencing target gene sites. For effective endogenous RNA interference (RNAi), proper siRNA delivery vehicles are essential, to take the siRNA inside cells and protect them during the circulation. Carbon nanomaterials (CNMs) have been successfully applied in biomedicine and biosensor based on their ultra-high surface functionalization and nucleic acid molecular loading capacity. Recently, CNMs have drawn considerable research interest and expectation as potential non-viral vectors for siRNA delivery. Here we reviewed the recent application of CNMs in gene delivery for RNAi, mainly about fullerenes, carbon nanotubes (CNTs) and graphene.
KeywordEfficient Intracellular Delivery Cationic Tetraamino Fullerene Functionalized Graphene Oxide Drug-delivery Sirna Delivery Biomedical Applications Photothermal Therapy Biosensing Platform Cellular Delivery Molecular Beacon
Indexed BySCI
Language英语
WOS IDWOS:000357937500014
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/24866
Collection中科院上海应用物理研究所2011-2019年
Corresponding AuthorLiu, G (reprint author), Shanghai Inst Measurement & Testing Technol, Shanghai 201800, Peoples R China.
Recommended Citation
GB/T 7714
Li, LY,Wen, YL,Xu, Q,et al. Application of Carbon Nanomaterials in Gene Delivery for Endogenous RNA Interference In Vitro and In Vivo[J]. CURRENT PHARMACEUTICAL DESIGN,2015,21(22):3191—3198.
APA Li, LY.,Wen, YL.,Xu, Q.,Xu, L.,Liu, D.,...&Liu, G .(2015).Application of Carbon Nanomaterials in Gene Delivery for Endogenous RNA Interference In Vitro and In Vivo.CURRENT PHARMACEUTICAL DESIGN,21(22),3191—3198.
MLA Li, LY,et al."Application of Carbon Nanomaterials in Gene Delivery for Endogenous RNA Interference In Vitro and In Vivo".CURRENT PHARMACEUTICAL DESIGN 21.22(2015):3191—3198.
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