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Association of Matrix Metalloproteinase-9 Gene-1562C/T Polymorphism with Essential Hypertension: A Systematic Review and Meta-Analysis Article
Yang, WC; Lu, JJ; Yang, L; Zhang, JJ; Zhang, JJ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai, Peoples R China.
2015
Source PublicationIRANIAN JOURNAL OF PUBLIC HEALTH
ISSN2251-6085
Volume44Issue:11Pages:1445—1452
Subtype期刊文献
AbstractBackground: Matrix metalloproteinase-9 (MMP-9) gene -1562C/T polymorphism could regulate its expression level and thus affected people's predisposition to essential hypertension. However, related studies yielded inconsistent or contradictory results. Methods: To evaluate the association of MMP-9 -1562C/T polymorphism with essential hypertension, we performed a meta-analysis by combining all available independent case-control studies (n=6). A systematic literature search of PubMed, Web of Science, Scopus and CNKI (Chinese National Knowledge Infrastructure) databases was conducted by two researchers independently for all relevant articles published before March 2015. Results: MMP-9 -1562C/T polymorphism was associated with essential hypertension under the allelic model (T vs. C, OR=1.36, 95% CI=1.17-1.59, P<0.0001). Subsequent sensitivity analysis confirmed the stability of the results. Such association was also observed in the dominant (TT+CT vs. CC, OR=1.30, 95% CI=1.10-1.54, P=0.002) and codominant (CT vs. TT+CC, OR=1.27, 95% CI=1.05-1.53, P=0.01) models but not in the recessive model (TT vs. CT+CC, OR=1.30, 95% CI=0.50-3.36, P=0.59). Conclusion: MMP-9 -1562C/T polymorphism was associated with the risk of essential hypertension.
KeywordChinese Han Population Matrix Metalloproteinases Risk-factors Gene Disease Inhibitors Atherosclerosis Susceptibility Expression Stiffness
Indexed BySCI
Language英语
WOS IDWOS:000365537200002
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/24868
Collection中科院上海应用物理研究所2011-2019年
Corresponding AuthorZhang, JJ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai, Peoples R China.
Recommended Citation
GB/T 7714
Yang, WC,Lu, JJ,Yang, L,et al. Association of Matrix Metalloproteinase-9 Gene-1562C/T Polymorphism with Essential Hypertension: A Systematic Review and Meta-Analysis Article[J]. IRANIAN JOURNAL OF PUBLIC HEALTH,2015,44(11):1445—1452.
APA Yang, WC,Lu, JJ,Yang, L,Zhang, JJ,&Zhang, JJ .(2015).Association of Matrix Metalloproteinase-9 Gene-1562C/T Polymorphism with Essential Hypertension: A Systematic Review and Meta-Analysis Article.IRANIAN JOURNAL OF PUBLIC HEALTH,44(11),1445—1452.
MLA Yang, WC,et al."Association of Matrix Metalloproteinase-9 Gene-1562C/T Polymorphism with Essential Hypertension: A Systematic Review and Meta-Analysis Article".IRANIAN JOURNAL OF PUBLIC HEALTH 44.11(2015):1445—1452.
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