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| Association of Matrix Metalloproteinase-9 Gene-1562C/T Polymorphism with Essential Hypertension: A Systematic Review and Meta-Analysis Article | |
| Yang, WC; Lu, JJ; Yang, L; Zhang, JJ; Zhang, JJ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai, Peoples R China. | |
| 2015 | |
| Source Publication | IRANIAN JOURNAL OF PUBLIC HEALTH
 |
| ISSN | 2251-6085 |
| Volume | 44Issue:11Pages:1445—1452 |
| Subtype | 期刊文献 |
| Abstract | Background: Matrix metalloproteinase-9 (MMP-9) gene -1562C/T polymorphism could regulate its expression level and thus affected people's predisposition to essential hypertension. However, related studies yielded inconsistent or contradictory results. Methods: To evaluate the association of MMP-9 -1562C/T polymorphism with essential hypertension, we performed a meta-analysis by combining all available independent case-control studies (n=6). A systematic literature search of PubMed, Web of Science, Scopus and CNKI (Chinese National Knowledge Infrastructure) databases was conducted by two researchers independently for all relevant articles published before March 2015. Results: MMP-9 -1562C/T polymorphism was associated with essential hypertension under the allelic model (T vs. C, OR=1.36, 95% CI=1.17-1.59, P<0.0001). Subsequent sensitivity analysis confirmed the stability of the results. Such association was also observed in the dominant (TT+CT vs. CC, OR=1.30, 95% CI=1.10-1.54, P=0.002) and codominant (CT vs. TT+CC, OR=1.27, 95% CI=1.05-1.53, P=0.01) models but not in the recessive model (TT vs. CT+CC, OR=1.30, 95% CI=0.50-3.36, P=0.59). Conclusion: MMP-9 -1562C/T polymorphism was associated with the risk of essential hypertension. |
| Keyword | Chinese Han Population Matrix Metalloproteinases Risk-factors Gene Disease Inhibitors Atherosclerosis Susceptibility Expression Stiffness |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000365537200002 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/24868 |
| Collection | 中科院上海应用物理研究所2011-2019年 |
| Corresponding Author | Zhang, JJ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai, Peoples R China. |
| Recommended Citation GB/T 7714 | Yang, WC,Lu, JJ,Yang, L,et al. Association of Matrix Metalloproteinase-9 Gene-1562C/T Polymorphism with Essential Hypertension: A Systematic Review and Meta-Analysis Article[J]. IRANIAN JOURNAL OF PUBLIC HEALTH,2015,44(11):1445—1452. |
| APA | Yang, WC,Lu, JJ,Yang, L,Zhang, JJ,&Zhang, JJ .(2015).Association of Matrix Metalloproteinase-9 Gene-1562C/T Polymorphism with Essential Hypertension: A Systematic Review and Meta-Analysis Article.IRANIAN JOURNAL OF PUBLIC HEALTH,44(11),1445—1452. |
| MLA | Yang, WC,et al."Association of Matrix Metalloproteinase-9 Gene-1562C/T Polymorphism with Essential Hypertension: A Systematic Review and Meta-Analysis Article".IRANIAN JOURNAL OF PUBLIC HEALTH 44.11(2015):1445—1452. |
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| Association of Matri（375KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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