Excess titanium dioxide nanoparticles on the cell surface induce cytotoxicity by hindering ion exchange and disrupting exocytosis processes
Wang, YL; Yao, CJ; Li, CC; Ding, L; Liu, J; Dong, P; Fang, HP; Lei, ZD; Shi, GS; Wu, MH; Wang, YL (reprint author), Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China.
2015
发表期刊NANOSCALE
ISSN2040-3364
卷号7期号:30页码:13105—13115
文章类型期刊文献
摘要To date, considerable effort has been devoted to determine the potential toxicity of nanoparticles to cells and organisms. However, determining the mechanism of cytotoxicity induced by different types of nanoparticles remains challenging. Herein, typically low toxicity nanomaterials were used as a model to investigate the mechanism of cytotoxicity induced by low toxicity nanomaterials. We studied the effect of nano-TiO2, nano-Al2O3 and nano-SiO2 deposition films on the ion concentration on a cell-free system simulating the cell membrane. The results showed that the ion concentration of K+, Ca2+, Na+, Mg2+ and SO42- decreased significantly following filtration of the prepared deposition films. More specifically, at a high nano-TiO2 concentration (200 mg L-1) and a long nano-TiO2 deposition time (48 h), the concentration of Na+ decreased from 2958.01 to 2775.72, 2749.86, 2757.36, and 2719.82 mg L-1, respectively, for the four types of nano-TiO2 studied. Likewise, the concentration of SO42- decreased from 38.83 to 35.00, 35.80, 35.40, and 35.27 mg L-1, respectively. The other two kinds of typical low toxicity nanomaterials (nano-Al2O3 and nano-SiO2) have a similar impact on the ion concentration change trend. Adsorption of ions on nanoparticles and the hydrated shell around the ions strongly hindered the ions through the nanoparticle films. The endocytosed nanoparticles could be released from the cells without inducing cytotoxicity. Hindering the ion exchange and disrupting the exocytosis process are the main factors that induce cytotoxicity in the presence of excess nano-TiO2 on the cell surface. The current findings may offer a universal principle for understanding the mechanism of cytotoxicity induced by low toxicity nanomaterials.
关键词Junctional Intercellular Communication Metal-oxide Nanoparticles In-vitro Silica Nanoparticles Molecular-dynamics Epithelial-cells Mammalian-cells Toxicity Tio2 Macrophages
收录类别SCI
语种英语
WOS记录号WOS:000358615200037
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/24924
专题中科院上海应用物理研究所2011-2018年
通讯作者Wang, YL (reprint author), Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China.
推荐引用方式
GB/T 7714
Wang, YL,Yao, CJ,Li, CC,et al. Excess titanium dioxide nanoparticles on the cell surface induce cytotoxicity by hindering ion exchange and disrupting exocytosis processes[J]. NANOSCALE,2015,7(30):13105—13115.
APA Wang, YL.,Yao, CJ.,Li, CC.,Ding, L.,Liu, J.,...&Wang, YL .(2015).Excess titanium dioxide nanoparticles on the cell surface induce cytotoxicity by hindering ion exchange and disrupting exocytosis processes.NANOSCALE,7(30),13105—13115.
MLA Wang, YL,et al."Excess titanium dioxide nanoparticles on the cell surface induce cytotoxicity by hindering ion exchange and disrupting exocytosis processes".NANOSCALE 7.30(2015):13105—13115.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Excess titanium diox(3942KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, YL]的文章
[Yao, CJ]的文章
[Li, CC]的文章
百度学术
百度学术中相似的文章
[Wang, YL]的文章
[Yao, CJ]的文章
[Li, CC]的文章
必应学术
必应学术中相似的文章
[Wang, YL]的文章
[Yao, CJ]的文章
[Li, CC]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Excess titanium dioxide nanoparticles on the cell surface induce cytotoxicity by hindering ion exchange and disrupting exocytosis processes.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。