Integration of Switchable DNA-Based Hydrogels with Surfaces by the Hybridization Chain Reaction
Kahn, JS; Trifonov, A; Cecconello, A; Guo, WW; Fan, CH; Willner, I; Willner, I (reprint author), Hebrew Univ Jerusalem, Minerva Ctr Complex Biohybrid Syst, Inst Chem, IL-91904 Jerusalem, Israel.
2015
发表期刊NANO LETTERS
ISSN1530-6984
卷号15期号:11页码:7773—7778
文章类型期刊文献
摘要A novel method to assemble acrylamide/acrydite DNA copolymer hydrogels on surfaces, specifically gold-coated surfaces, is introduced. The method involves the synthesis of two different copolymer chains consisting of hairpin A, HA, modified acrylamide copolymer and hairpin B, H-B, acrylamide copolymer. In the presence of a nucleic acid promoter monolayer associated with the surface, the hybridization chain reaction between the two hairpin-modified polymer chains is initiated, giving rise to the cross-opening of hairpins HA and HB and the formation of a cross-linked hydrogel on the surface. By the cofunctionalization of the H-A- and Ha-modified polymer chains with G-rich DNA tethers that include the G-quadruplex subunits, hydrogels of switchable stiffness are generated. In the presence of K+-ions, the hydrogel associated with the surface is cooperatively cross-linked by duplex units of H-A and H-B, and K+-ion-stabilized G-quadruplex units, giving rise to a stiff hydrogel. The 18-crown-6-ether-stimulated elimination of the K+-ions dissociates the bridging G-quadruplex units, resulting in a hydrogel of reduced stiffness. The duplex/G-quadruplex cooperatively stabilized hydrogel associated with the surface reveals switchable electrocatalytic properties. The incorporation of hemin into the G-quadruplex units electrocatalyzes the reduction of H2O2. The 18-crown-6-ether stimulated dissociation of the hemin/G-quadruplex bridging units leads to a catalytically inactive hydrogel.
关键词Cross-linked Hydrogel Horseradish-peroxidase Impedance Spectroscopy Conformational Switch Responsive Hydrogels Binding-affinity Visual Detection Thin-films Dnazyme Release
语种英语
WOS记录号WOS:000364725400090
引用统计
被引频次:49[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/24967
专题中科院上海应用物理研究所2011-2018年
通讯作者Willner, I (reprint author), Hebrew Univ Jerusalem, Minerva Ctr Complex Biohybrid Syst, Inst Chem, IL-91904 Jerusalem, Israel.
推荐引用方式
GB/T 7714
Kahn, JS,Trifonov, A,Cecconello, A,et al. Integration of Switchable DNA-Based Hydrogels with Surfaces by the Hybridization Chain Reaction[J]. NANO LETTERS,2015,15(11):7773—7778.
APA Kahn, JS.,Trifonov, A.,Cecconello, A.,Guo, WW.,Fan, CH.,...&Willner, I .(2015).Integration of Switchable DNA-Based Hydrogels with Surfaces by the Hybridization Chain Reaction.NANO LETTERS,15(11),7773—7778.
MLA Kahn, JS,et al."Integration of Switchable DNA-Based Hydrogels with Surfaces by the Hybridization Chain Reaction".NANO LETTERS 15.11(2015):7773—7778.
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