Interaction of Al-induced peptide backbone ring structure with the sidechains of His, Phe, Trp and Tyr
Wu, QL; Song, B; Song, B (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Div Interfacial Water, Shanghai 201800, Peoples R China.
2015
发表期刊NUCLEAR SCIENCE AND TECHNIQUES
ISSN1001-8042
卷号26期号:4页码:
文章类型期刊文献
摘要Aluminium is widely used as an antimicrobial coagulant, food additive, and cookware. However, many reports indicate that aluminium may be a critical factor in many amyloid diseases, such as Alzheimer's disease and Parkinson's disease. Unfortunately, the underlying mechanism is still poorly understood, which limits efforts to prevent and treat these diseases. In this paper, using an ab initio method, we studied the interaction of Al-backbone ring structure with the pi-electron-rich sidechains of His, Phe, Trp, and Tyr. We found that in the absence of water, the Al-backbone ring can stably bind with those sidechains. In the presence of water, the Al-backbone ring can bind to the His sidechain and cannot bind to the other sidechains. As revealed by further investigations, this could be attributed to the fact that there was a coordinate bond of the Al-backbone ring with the His sidechain, while there were the pi-pi stacking and cation-pi-like interactions with the other sidechains. These findings potentially provide a molecular understanding of Al-related toxicity, and may be helpful in designing drugs for those aforementioned aluminum-linked diseases and encourage treatment of Al-polluted water.
关键词Cation-pi Interactions Alzheimers-disease Neurofibrillary Degeneration Biological Recognition Aromatic Rings Aluminum Water Pathways Removal Virus
语种英语
WOS记录号WOS:000361645000016
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/24968
专题中科院上海应用物理研究所2011-2018年
通讯作者Song, B (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Div Interfacial Water, Shanghai 201800, Peoples R China.
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Wu, QL,Song, B,Song, B . Interaction of Al-induced peptide backbone ring structure with the sidechains of His, Phe, Trp and Tyr[J]. NUCLEAR SCIENCE AND TECHNIQUES,2015,26(4):—.
APA Wu, QL,Song, B,&Song, B .(2015).Interaction of Al-induced peptide backbone ring structure with the sidechains of His, Phe, Trp and Tyr.NUCLEAR SCIENCE AND TECHNIQUES,26(4),—.
MLA Wu, QL,et al."Interaction of Al-induced peptide backbone ring structure with the sidechains of His, Phe, Trp and Tyr".NUCLEAR SCIENCE AND TECHNIQUES 26.4(2015):—.
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