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Interaction of Al-induced peptide backbone ring structure with the sidechains of His, Phe, Trp and Tyr
Wu, QL; Song, B; Song, B (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Div Interfacial Water, Shanghai 201800, Peoples R China.
2015
Source PublicationNUCLEAR SCIENCE AND TECHNIQUES
ISSN1001-8042
Volume26Issue:4Pages:
Subtype期刊文献
AbstractAluminium is widely used as an antimicrobial coagulant, food additive, and cookware. However, many reports indicate that aluminium may be a critical factor in many amyloid diseases, such as Alzheimer's disease and Parkinson's disease. Unfortunately, the underlying mechanism is still poorly understood, which limits efforts to prevent and treat these diseases. In this paper, using an ab initio method, we studied the interaction of Al-backbone ring structure with the pi-electron-rich sidechains of His, Phe, Trp, and Tyr. We found that in the absence of water, the Al-backbone ring can stably bind with those sidechains. In the presence of water, the Al-backbone ring can bind to the His sidechain and cannot bind to the other sidechains. As revealed by further investigations, this could be attributed to the fact that there was a coordinate bond of the Al-backbone ring with the His sidechain, while there were the pi-pi stacking and cation-pi-like interactions with the other sidechains. These findings potentially provide a molecular understanding of Al-related toxicity, and may be helpful in designing drugs for those aforementioned aluminum-linked diseases and encourage treatment of Al-polluted water.
KeywordCation-pi Interactions Alzheimers-disease Neurofibrillary Degeneration Biological Recognition Aromatic Rings Aluminum Water Pathways Removal Virus
Language英语
WOS IDWOS:000361645000016
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/24968
Collection中科院上海应用物理研究所2011-2018年
Corresponding AuthorSong, B (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Div Interfacial Water, Shanghai 201800, Peoples R China.
Recommended Citation
GB/T 7714
Wu, QL,Song, B,Song, B . Interaction of Al-induced peptide backbone ring structure with the sidechains of His, Phe, Trp and Tyr[J]. NUCLEAR SCIENCE AND TECHNIQUES,2015,26(4):—.
APA Wu, QL,Song, B,&Song, B .(2015).Interaction of Al-induced peptide backbone ring structure with the sidechains of His, Phe, Trp and Tyr.NUCLEAR SCIENCE AND TECHNIQUES,26(4),—.
MLA Wu, QL,et al."Interaction of Al-induced peptide backbone ring structure with the sidechains of His, Phe, Trp and Tyr".NUCLEAR SCIENCE AND TECHNIQUES 26.4(2015):—.
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