CAS OpenIR  > 中科院上海应用物理研究所2011-2018年
One-step separation of nine structural analogues from Poria cocos (Schw.) Wolf. via tandem high-speed counter-current chromatography
Zeng, HL; Liu, Q; Yu, JG; Jiang, XY; Wu, ZL; Wang, ML; Chen, M; Chen, XQ; Chen, XQ (reprint author), Cent S Univ, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China.
2015
Source PublicationJOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
ISSN1570-0232
Volume1004Pages:10—16
Subtype期刊文献
AbstractA novel one-step separation strategy tandem high-speed counter-current chromatography (HSCCC) was developed with a six-port valve serving as the switch interface. Nine structural analogues including three isomers were successfully isolated from Porta cocos (Schw.) Wolf. by one step. Compared with conventional HSCCC, peak resolution of target compounds was effectively improved in tandem one. Purities of isolated compounds were all over 90% as determined by HPLC. Their structures were then identified via UV, MS and H-1 NMR, and eventually assigned as poricoic acid B (1), poricoic acid A (2), 3 beta,16 alpha-dihydroxylanosta-7, 9(11), 24-trien-21-oic acid (3), dehydrotumulosic acid (4), polyporenic acid C (5), 3-epi-dehydrotumulosic acid (6), 3-o-acetyl-16 alpha-hydroxydehydrotrametenolic acid (7), dehydropachymic acid (8) and dehydrotrametenolic acid (9) respectively. The results indicated that tandem HSCCC can effectively improve peak resolution of target compounds, and can be a good candidate for HSCCC separation of structural analogues. (C) 2015 Elsevier B.V. All rights reserved.
KeywordMicrowave-assisted Extraction Preparative Isolation Purification Alkaloids Hyphenation Triterpenes Elution
Language英语
WOS IDWOS:000364246300002
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/25008
Collection中科院上海应用物理研究所2011-2018年
Corresponding AuthorChen, XQ (reprint author), Cent S Univ, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China.
Recommended Citation
GB/T 7714
Zeng, HL,Liu, Q,Yu, JG,et al. One-step separation of nine structural analogues from Poria cocos (Schw.) Wolf. via tandem high-speed counter-current chromatography[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2015,1004:10—16.
APA Zeng, HL.,Liu, Q.,Yu, JG.,Jiang, XY.,Wu, ZL.,...&Chen, XQ .(2015).One-step separation of nine structural analogues from Poria cocos (Schw.) Wolf. via tandem high-speed counter-current chromatography.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,1004,10—16.
MLA Zeng, HL,et al."One-step separation of nine structural analogues from Poria cocos (Schw.) Wolf. via tandem high-speed counter-current chromatography".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 1004(2015):10—16.
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