Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| Reversible Regulation of Catalytic Activity of Gold Nanoparticles with DNA Nanomachines | |
| Zhou, PP; Jia, SS; Pan, D; Wang, LH; Gao, JM; Lu, JX; Shi, JY; Tang, ZS; Liu, HJ; Tang, ZS (reprint author), Shanghai Jiao Tong Univ, Shanghai Key Lab Stomatol, Sch Med, Peoples Hosp 9,Dept Endodont, Shanghai 200011, Peoples R China. | |
| 2015 | |
| Source Publication | SCIENTIFIC REPORTS
 |
| ISSN | 2045-2322 |
| Volume | 5Pages:— |
| Subtype | 期刊文献 |
| Abstract | Reversible catalysis regulation has gained much attention and traditional strategies utilized reversible ligand coordination for switching catalyst's conformations. However, it remains challenging to regulate the catalytic activity of metal nanoparticle-based catalysts. Herein, we report a new DNA nanomachine-driven reversible nano-shield strategy for circumventing this problem. The basic idea is based on the fact that the conformational change of surface-attached DNA nanomachines will cause the variation of the exposed surface active area on metal nanoparticles. As a proof-of-concept study, we immobilized G-rich DNA strands on gold nanoparticles (AuNPs) which have glucose oxidase (GOx) like activity. Through the reversible conformational change of the G-rich DNA between a flexible single-stranded form and a compact G-quadruplex form, the catalytic activity of AuNPs has been regulated reversibly for several cycles. This strategy is reliable and robust, which demonstrated the possibility of reversibly adjusting catalytic activity with external surface coverage switching, rather than coordination interactions. |
| Keyword | Enzyme Cascade Reaction Machine Complex Nanotechnology Hybridization Selectivity Mimicking Chemistry Devices Growth |
| Language | 英语 |
| WOS ID | WOS:000361598200001 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/25032 |
| Collection | 中科院上海应用物理研究所2011-2020年 |
| Corresponding Author | Tang, ZS (reprint author), Shanghai Jiao Tong Univ, Shanghai Key Lab Stomatol, Sch Med, Peoples Hosp 9,Dept Endodont, Shanghai 200011, Peoples R China. |
| Recommended Citation GB/T 7714 | Zhou, PP,Jia, SS,Pan, D,et al. Reversible Regulation of Catalytic Activity of Gold Nanoparticles with DNA Nanomachines[J]. SCIENTIFIC REPORTS,2015,5:—. |
| APA | Zhou, PP.,Jia, SS.,Pan, D.,Wang, LH.,Gao, JM.,...&Tang, ZS .(2015).Reversible Regulation of Catalytic Activity of Gold Nanoparticles with DNA Nanomachines.SCIENTIFIC REPORTS,5,—. |
| MLA | Zhou, PP,et al."Reversible Regulation of Catalytic Activity of Gold Nanoparticles with DNA Nanomachines".SCIENTIFIC REPORTS 5(2015):—. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Reversible Regulatio（559KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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