Reversible Regulation of Catalytic Activity of Gold Nanoparticles with DNA Nanomachines
Zhou, PP; Jia, SS; Pan, D; Wang, LH; Gao, JM; Lu, JX; Shi, JY; Tang, ZS; Liu, HJ; Tang, ZS (reprint author), Shanghai Jiao Tong Univ, Shanghai Key Lab Stomatol, Sch Med, Peoples Hosp 9,Dept Endodont, Shanghai 200011, Peoples R China.
2015
发表期刊SCIENTIFIC REPORTS
ISSN2045-2322
卷号5页码:
文章类型期刊文献
摘要Reversible catalysis regulation has gained much attention and traditional strategies utilized reversible ligand coordination for switching catalyst's conformations. However, it remains challenging to regulate the catalytic activity of metal nanoparticle-based catalysts. Herein, we report a new DNA nanomachine-driven reversible nano-shield strategy for circumventing this problem. The basic idea is based on the fact that the conformational change of surface-attached DNA nanomachines will cause the variation of the exposed surface active area on metal nanoparticles. As a proof-of-concept study, we immobilized G-rich DNA strands on gold nanoparticles (AuNPs) which have glucose oxidase (GOx) like activity. Through the reversible conformational change of the G-rich DNA between a flexible single-stranded form and a compact G-quadruplex form, the catalytic activity of AuNPs has been regulated reversibly for several cycles. This strategy is reliable and robust, which demonstrated the possibility of reversibly adjusting catalytic activity with external surface coverage switching, rather than coordination interactions.
关键词Enzyme Cascade Reaction Machine Complex Nanotechnology Hybridization Selectivity Mimicking Chemistry Devices Growth
语种英语
WOS记录号WOS:000361598200001
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/25032
专题中科院上海应用物理研究所2011-2018年
通讯作者Tang, ZS (reprint author), Shanghai Jiao Tong Univ, Shanghai Key Lab Stomatol, Sch Med, Peoples Hosp 9,Dept Endodont, Shanghai 200011, Peoples R China.
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GB/T 7714
Zhou, PP,Jia, SS,Pan, D,et al. Reversible Regulation of Catalytic Activity of Gold Nanoparticles with DNA Nanomachines[J]. SCIENTIFIC REPORTS,2015,5:—.
APA Zhou, PP.,Jia, SS.,Pan, D.,Wang, LH.,Gao, JM.,...&Tang, ZS .(2015).Reversible Regulation of Catalytic Activity of Gold Nanoparticles with DNA Nanomachines.SCIENTIFIC REPORTS,5,—.
MLA Zhou, PP,et al."Reversible Regulation of Catalytic Activity of Gold Nanoparticles with DNA Nanomachines".SCIENTIFIC REPORTS 5(2015):—.
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