Reversible Regulation of Catalytic Activity of Gold Nanoparticles with DNA Nanomachines

CAS OpenIR > 中科院上海应用物理研究所2011-2019年

	Reversible Regulation of Catalytic Activity of Gold Nanoparticles with DNA Nanomachines
	Zhou, PP; Jia, SS; Pan, D; Wang, LH; Gao, JM; Lu, JX; Shi, JY; Tang, ZS; Liu, HJ; Tang, ZS (reprint author), Shanghai Jiao Tong Univ, Shanghai Key Lab Stomatol, Sch Med, Peoples Hosp 9,Dept Endodont, Shanghai 200011, Peoples R China.
	2015
Source Publication	SCIENTIFIC REPORTS
ISSN	2045-2322
Volume	5 Pages:—
Subtype	期刊文献
Abstract	Reversible catalysis regulation has gained much attention and traditional strategies utilized reversible ligand coordination for switching catalyst's conformations. However, it remains challenging to regulate the catalytic activity of metal nanoparticle-based catalysts. Herein, we report a new DNA nanomachine-driven reversible nano-shield strategy for circumventing this problem. The basic idea is based on the fact that the conformational change of surface-attached DNA nanomachines will cause the variation of the exposed surface active area on metal nanoparticles. As a proof-of-concept study, we immobilized G-rich DNA strands on gold nanoparticles (AuNPs) which have glucose oxidase (GOx) like activity. Through the reversible conformational change of the G-rich DNA between a flexible single-stranded form and a compact G-quadruplex form, the catalytic activity of AuNPs has been regulated reversibly for several cycles. This strategy is reliable and robust, which demonstrated the possibility of reversibly adjusting catalytic activity with external surface coverage switching, rather than coordination interactions.
Keyword	Enzyme Cascade Reaction Machine Complex Nanotechnology Hybridization Selectivity Mimicking Chemistry Devices Growth
Language	英语
WOS ID	WOS:000361598200001
Citation statistics	Cited Times:7[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.sinap.ac.cn/handle/331007/25032
Collection	中科院上海应用物理研究所2011-2019年
Corresponding Author	Tang, ZS (reprint author), Shanghai Jiao Tong Univ, Shanghai Key Lab Stomatol, Sch Med, Peoples Hosp 9,Dept Endodont, Shanghai 200011, Peoples R China.
Recommended Citation GB/T 7714	Zhou, PP,Jia, SS,Pan, D,et al. Reversible Regulation of Catalytic Activity of Gold Nanoparticles with DNA Nanomachines[J]. SCIENTIFIC REPORTS,2015,5:—.
APA	Zhou, PP.,Jia, SS.,Pan, D.,Wang, LH.,Gao, JM.,...&Tang, ZS .(2015).Reversible Regulation of Catalytic Activity of Gold Nanoparticles with DNA Nanomachines.SCIENTIFIC REPORTS,5,—.
MLA	Zhou, PP,et al."Reversible Regulation of Catalytic Activity of Gold Nanoparticles with DNA Nanomachines".SCIENTIFIC REPORTS 5(2015):—.

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