Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| Study on technetium-99m labeling of graphene oxide nanosheets through click chemistry-Tc-99m labeling of graphene oxide nanosheets | |
| Jiang, DW; Peng, C; Sun, YH; Jia, LN; Li, JB; Zhang, L; Zhang, L (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China. | |
| 2015 | |
| 发表期刊 | NUCLEAR SCIENCE AND TECHNIQUES
 |
| ISSN | 1001-8042 |
| 卷号 | 26期号:4页码:— |
| 文章类型 | 期刊文献 |
| 摘要 | Graphene oxide (GO) nanosheets possess several advantages, such as a large surface, outstanding biocompatibility, and straightforward chemical modification capability. They also have great potential as a drug-carrier. In this article, we radiolabeled GO nanosheets with Tc-99m, which satisfies the potential needs of micro-SPECT imaging probes in pre-clinical and clinical research. GO nanosheets were synthesized through the modified Hummers' method, then GO nanosheets with azide group covalently functionalized in two steps were conjugated to DOTA (1,4,7,10-tetraazacyclododecane-N,N',N '',N'''-tetraacetic acid) and functionalized with an alkynyl group by means of click chemistry. Then through the addition and reduction of technetium-99m, the Tc-99m-DOTA-GO were attained. DOTA-conjugated GOs with lateral dimensions of 500-600 am were synthesized. Both atomic force microscopy (AFM) and FT-IR were performed to characterize the GO-DOTA. Labeling efficiency of GO-DOTA with Tc-99m was > 90% and radiochemical purities were > 96% with purification. We successfully synthesized graphene oxide derivatives, DOTA-conjugated GOs, via Click Chemistry, and it was labeled with Tc-99m for SPECT imaging. High radiolabeling efficiency makes GO nanosheets suitable platforms for future molecular imaging research. |
| 关键词 | Tumor Vasculature Drug-delivery Nano-graphene Nanographene Receptor Carbon |
| 语种 | 英语 |
| WOS记录号 | WOS:000361645000005 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.sinap.ac.cn/handle/331007/25054 |
| 专题 | 中科院上海应用物理研究所2011-2018年 |
| 通讯作者 | Zhang, L (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Jiang, DW,Peng, C,Sun, YH,et al. Study on technetium-99m labeling of graphene oxide nanosheets through click chemistry-Tc-99m labeling of graphene oxide nanosheets[J]. NUCLEAR SCIENCE AND TECHNIQUES,2015,26(4):—. |
| APA | Jiang, DW.,Peng, C.,Sun, YH.,Jia, LN.,Li, JB.,...&Zhang, L .(2015).Study on technetium-99m labeling of graphene oxide nanosheets through click chemistry-Tc-99m labeling of graphene oxide nanosheets.NUCLEAR SCIENCE AND TECHNIQUES,26(4),—. |
| MLA | Jiang, DW,et al."Study on technetium-99m labeling of graphene oxide nanosheets through click chemistry-Tc-99m labeling of graphene oxide nanosheets".NUCLEAR SCIENCE AND TECHNIQUES 26.4(2015):—. |
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| Study on technetium-（473KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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