Study on technetium-99m labeling of graphene oxide nanosheets through click chemistry-Tc-99m labeling of graphene oxide nanosheets

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	Study on technetium-99m labeling of graphene oxide nanosheets through click chemistry-Tc-99m labeling of graphene oxide nanosheets
	Jiang, DW; Peng, C; Sun, YH; Jia, LN; Li, JB; Zhang, L; Zhang, L (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China.
	2015
Source Publication	NUCLEAR SCIENCE AND TECHNIQUES
ISSN	1001-8042
Volume	26 Issue:4 Pages:—
Subtype	期刊文献
Abstract	Graphene oxide (GO) nanosheets possess several advantages, such as a large surface, outstanding biocompatibility, and straightforward chemical modification capability. They also have great potential as a drug-carrier. In this article, we radiolabeled GO nanosheets with Tc-99m, which satisfies the potential needs of micro-SPECT imaging probes in pre-clinical and clinical research. GO nanosheets were synthesized through the modified Hummers' method, then GO nanosheets with azide group covalently functionalized in two steps were conjugated to DOTA (1,4,7,10-tetraazacyclododecane-N,N',N '',N'''-tetraacetic acid) and functionalized with an alkynyl group by means of click chemistry. Then through the addition and reduction of technetium-99m, the Tc-99m-DOTA-GO were attained. DOTA-conjugated GOs with lateral dimensions of 500-600 am were synthesized. Both atomic force microscopy (AFM) and FT-IR were performed to characterize the GO-DOTA. Labeling efficiency of GO-DOTA with Tc-99m was > 90% and radiochemical purities were > 96% with purification. We successfully synthesized graphene oxide derivatives, DOTA-conjugated GOs, via Click Chemistry, and it was labeled with Tc-99m for SPECT imaging. High radiolabeling efficiency makes GO nanosheets suitable platforms for future molecular imaging research.
Keyword	Tumor Vasculature Drug-delivery Nano-graphene Nanographene Receptor Carbon
Language	英语
WOS ID	WOS:000361645000005
Citation statistics
Document Type	期刊论文
Identifier	http://ir.sinap.ac.cn/handle/331007/25054
Collection	中科院上海应用物理研究所2011-2019年
Corresponding Author	Zhang, L (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China.
Recommended Citation GB/T 7714	Jiang, DW,Peng, C,Sun, YH,et al. Study on technetium-99m labeling of graphene oxide nanosheets through click chemistry-Tc-99m labeling of graphene oxide nanosheets[J]. NUCLEAR SCIENCE AND TECHNIQUES,2015,26(4):—.
APA	Jiang, DW.,Peng, C.,Sun, YH.,Jia, LN.,Li, JB.,...&Zhang, L .(2015).Study on technetium-99m labeling of graphene oxide nanosheets through click chemistry-Tc-99m labeling of graphene oxide nanosheets.NUCLEAR SCIENCE AND TECHNIQUES,26(4),—.
MLA	Jiang, DW,et al."Study on technetium-99m labeling of graphene oxide nanosheets through click chemistry-Tc-99m labeling of graphene oxide nanosheets".NUCLEAR SCIENCE AND TECHNIQUES 26.4(2015):—.

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