Study on technetium-99m labeling of graphene oxide nanosheets through click chemistry-Tc-99m labeling of graphene oxide nanosheets
Jiang, DW; Peng, C; Sun, YH; Jia, LN; Li, JB; Zhang, L; Zhang, L (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China.
2015
发表期刊NUCLEAR SCIENCE AND TECHNIQUES
ISSN1001-8042
卷号26期号:4页码:
文章类型期刊文献
摘要Graphene oxide (GO) nanosheets possess several advantages, such as a large surface, outstanding biocompatibility, and straightforward chemical modification capability. They also have great potential as a drug-carrier. In this article, we radiolabeled GO nanosheets with Tc-99m, which satisfies the potential needs of micro-SPECT imaging probes in pre-clinical and clinical research. GO nanosheets were synthesized through the modified Hummers' method, then GO nanosheets with azide group covalently functionalized in two steps were conjugated to DOTA (1,4,7,10-tetraazacyclododecane-N,N',N '',N'''-tetraacetic acid) and functionalized with an alkynyl group by means of click chemistry. Then through the addition and reduction of technetium-99m, the Tc-99m-DOTA-GO were attained. DOTA-conjugated GOs with lateral dimensions of 500-600 am were synthesized. Both atomic force microscopy (AFM) and FT-IR were performed to characterize the GO-DOTA. Labeling efficiency of GO-DOTA with Tc-99m was > 90% and radiochemical purities were > 96% with purification. We successfully synthesized graphene oxide derivatives, DOTA-conjugated GOs, via Click Chemistry, and it was labeled with Tc-99m for SPECT imaging. High radiolabeling efficiency makes GO nanosheets suitable platforms for future molecular imaging research.
关键词Tumor Vasculature Drug-delivery Nano-graphene Nanographene Receptor Carbon
语种英语
WOS记录号WOS:000361645000005
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/25054
专题中科院上海应用物理研究所2011-2018年
通讯作者Zhang, L (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China.
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GB/T 7714
Jiang, DW,Peng, C,Sun, YH,et al. Study on technetium-99m labeling of graphene oxide nanosheets through click chemistry-Tc-99m labeling of graphene oxide nanosheets[J]. NUCLEAR SCIENCE AND TECHNIQUES,2015,26(4):—.
APA Jiang, DW.,Peng, C.,Sun, YH.,Jia, LN.,Li, JB.,...&Zhang, L .(2015).Study on technetium-99m labeling of graphene oxide nanosheets through click chemistry-Tc-99m labeling of graphene oxide nanosheets.NUCLEAR SCIENCE AND TECHNIQUES,26(4),—.
MLA Jiang, DW,et al."Study on technetium-99m labeling of graphene oxide nanosheets through click chemistry-Tc-99m labeling of graphene oxide nanosheets".NUCLEAR SCIENCE AND TECHNIQUES 26.4(2015):—.
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