Synchrotron radiation X-ray fluorescence analysis of Fe, Zn and Cu in mice brain associated with Parkinson's disease
Tian, T; Zhang, JC; Lei, HZ; Ying, Z; Shi, JY; Hu, J; Huang, Q; Fan, CH; Sun, YH; Sun, YH (reprint author), Chinese Acad Sci, Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China.
2015
发表期刊NUCLEAR SCIENCE AND TECHNIQUES
ISSN1001-8042
卷号26期号:3页码:
文章类型期刊文献
摘要The contents and distributions of metal elements in the brain are closely related to neurodegenerative diseases. In this study, we examined Fe, Cu and Zn contents in the brain section associated with Parkinson's disease (PD) using synchrotron radiation X-ray fluorescence (SRXRF). PD mouse model induced by 1-methyl-4-phenyl-1,2,3,6-terahydropyridine (MPTP) was used for the elemental analysis (e.g., Fe, Cu and Zn) in the substantia nigra pars compacta (SNpc) region of mice brain tissue samples. We found that mice in the MPTP group had higher contents of Fe, Cu and Zn in the SNpc than the control group. After treating the PD mice with rapamycin, the contents of Fe, Cu and Zn were reduced, the dopamine neurons and motor function were rescued correspondingly. The results prompted that the SRXRF provided an ideal method for tracing and analyzing the metal elements in the brain section to assess the pathological changes of PD model and the therapeutic effect of drugs.
关键词Oxidative Stress Neurodegenerative Diseases Rapamycin Protects Mouse Model Cell-death Copper Metals Zinc Iron Accumulation
语种英语
WOS记录号WOS:000358109700019
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/25063
专题中科院上海应用物理研究所2011-2018年
通讯作者Sun, YH (reprint author), Chinese Acad Sci, Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China.
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Tian, T,Zhang, JC,Lei, HZ,et al. Synchrotron radiation X-ray fluorescence analysis of Fe, Zn and Cu in mice brain associated with Parkinson's disease[J]. NUCLEAR SCIENCE AND TECHNIQUES,2015,26(3):—.
APA Tian, T.,Zhang, JC.,Lei, HZ.,Ying, Z.,Shi, JY.,...&Sun, YH .(2015).Synchrotron radiation X-ray fluorescence analysis of Fe, Zn and Cu in mice brain associated with Parkinson's disease.NUCLEAR SCIENCE AND TECHNIQUES,26(3),—.
MLA Tian, T,et al."Synchrotron radiation X-ray fluorescence analysis of Fe, Zn and Cu in mice brain associated with Parkinson's disease".NUCLEAR SCIENCE AND TECHNIQUES 26.3(2015):—.
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