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Synchrotron radiation X-ray fluorescence analysis of Fe, Zn and Cu in mice brain associated with Parkinson's disease
Tian, T; Zhang, JC; Lei, HZ; Ying, Z; Shi, JY; Hu, J; Huang, Q; Fan, CH; Sun, YH; Sun, YH (reprint author), Chinese Acad Sci, Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China.
2015
Source PublicationNUCLEAR SCIENCE AND TECHNIQUES
ISSN1001-8042
Volume26Issue:3Pages:
Subtype期刊文献
AbstractThe contents and distributions of metal elements in the brain are closely related to neurodegenerative diseases. In this study, we examined Fe, Cu and Zn contents in the brain section associated with Parkinson's disease (PD) using synchrotron radiation X-ray fluorescence (SRXRF). PD mouse model induced by 1-methyl-4-phenyl-1,2,3,6-terahydropyridine (MPTP) was used for the elemental analysis (e.g., Fe, Cu and Zn) in the substantia nigra pars compacta (SNpc) region of mice brain tissue samples. We found that mice in the MPTP group had higher contents of Fe, Cu and Zn in the SNpc than the control group. After treating the PD mice with rapamycin, the contents of Fe, Cu and Zn were reduced, the dopamine neurons and motor function were rescued correspondingly. The results prompted that the SRXRF provided an ideal method for tracing and analyzing the metal elements in the brain section to assess the pathological changes of PD model and the therapeutic effect of drugs.
KeywordOxidative Stress Neurodegenerative Diseases Rapamycin Protects Mouse Model Cell-death Copper Metals Zinc Iron Accumulation
Language英语
WOS IDWOS:000358109700019
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Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/25063
Collection中科院上海应用物理研究所2011-2019年
Corresponding AuthorSun, YH (reprint author), Chinese Acad Sci, Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China.
Recommended Citation
GB/T 7714
Tian, T,Zhang, JC,Lei, HZ,et al. Synchrotron radiation X-ray fluorescence analysis of Fe, Zn and Cu in mice brain associated with Parkinson's disease[J]. NUCLEAR SCIENCE AND TECHNIQUES,2015,26(3):—.
APA Tian, T.,Zhang, JC.,Lei, HZ.,Ying, Z.,Shi, JY.,...&Sun, YH .(2015).Synchrotron radiation X-ray fluorescence analysis of Fe, Zn and Cu in mice brain associated with Parkinson's disease.NUCLEAR SCIENCE AND TECHNIQUES,26(3),—.
MLA Tian, T,et al."Synchrotron radiation X-ray fluorescence analysis of Fe, Zn and Cu in mice brain associated with Parkinson's disease".NUCLEAR SCIENCE AND TECHNIQUES 26.3(2015):—.
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