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Technical Note: Synchrotron-based high-energy x-ray phase sensitive microtomography for biomedical research
Liu, HQ; Wu, XZ; Xiao, TQ; Wu, XZ (reprint author), Univ Alabama Birmingham, Dept Radiol, Birmingham, AL 35249 USA.
2015
Source PublicationMEDICAL PHYSICS
ISSN0094-2405
Volume42Issue:10Pages:5595—5603
Subtype期刊文献
AbstractPurpose: Propagation-based phase-contrast CT (PPCT) utilizes highly sensitive phase-contrast technology applied to x-ray microtomography. Performing phase retrieval on the acquired angular projections can enhance image contrast and enable quantitative imaging. In this work, the authors demonstrate the validity and advantages of a novel technique for high-resolution PPCT by using the generalized phase-attenuation duality (PAD) method of phase retrieval. Methods: A high-resolution angular projection data set of a fish head specimen was acquired with a monochromatic 60-keV x-ray beam. In one approach, the projection data were directly used for tomographic reconstruction. In two other approaches, the projection data were preprocessed by phase retrieval based on either the linearized PAD method or the generalized PAD method. The reconstructed images from all three approaches were then compared in terms of tissue contrast-to-noise ratio and spatial resolution. Results: The authors' experimental results demonstrated the validity of the PPCT technique based on the generalized PAD-based method. In addition, the results show that the authors' technique is superior to the direct PPCT technique as well as the linearized PAD-based PPCT technique in terms of their relative capabilities for tissue discrimination and characterization. Conclusions: This novel PPCT technique demonstrates great potential for biomedical imaging, especially for applications that require high spatial resolution and limited radiation exposure. (C) 2015 American Association of Physicists in Medicine.
KeywordAttenuation Duality Contrast Tomography Fresnel Region Soft-tissue Retrieval Holotomography Interferometer Object Image
Language英语
WOS IDWOS:000362570100003
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/25069
Collection中科院上海应用物理研究所2011-2018年
Corresponding AuthorWu, XZ (reprint author), Univ Alabama Birmingham, Dept Radiol, Birmingham, AL 35249 USA.
Recommended Citation
GB/T 7714
Liu, HQ,Wu, XZ,Xiao, TQ,et al. Technical Note: Synchrotron-based high-energy x-ray phase sensitive microtomography for biomedical research[J]. MEDICAL PHYSICS,2015,42(10):5595—5603.
APA Liu, HQ,Wu, XZ,Xiao, TQ,&Wu, XZ .(2015).Technical Note: Synchrotron-based high-energy x-ray phase sensitive microtomography for biomedical research.MEDICAL PHYSICS,42(10),5595—5603.
MLA Liu, HQ,et al."Technical Note: Synchrotron-based high-energy x-ray phase sensitive microtomography for biomedical research".MEDICAL PHYSICS 42.10(2015):5595—5603.
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