CAS OpenIR  > 中科院上海应用物理研究所2011-2018年
Ultra-high-resolution 3D digitalized imaging of the cerebral angioarchitecture in rats using synchrotron radiation
Zhang, MQ; Zhou, L; Deng, QF; Xie, YY; Xiao, TQ; Cao, YZ; Zhang, JW; Chen, XM; Yin, XZ; Xiao, B; Xiao, B (reprint author), Cent S Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Hunan, Peoples R China.
2015
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume5Pages:
Subtype期刊文献
AbstractThe angioarchitecture is a fundamental aspect of brain development and physiology. However, available imaging tools are unsuited for non-destructive cerebral mapping of the functionally important three-dimensional (3D) vascular microstructures. To address this issue, we developed an ultra-high resolution 3D digitalized angioarchitectural map for rat brain, based on synchrotron radiation phase contrast imaging (SR-PCI) with pixel size of 5.92 mu m. This approach provides a systematic and detailed view of the cerebrovascular anatomy at the micrometer level without any need for contrast agents. From qualitative and quantitative perspectives, the present 3D data provide a considerable insight into the spatial vascular network for whole rodent brain, particularly for functionally important regions of interest, such as the hippocampus, pre-frontal cerebral cortex and the corpus striatum. We extended these results to synchrotron-based virtual micro-endoscopy, thus revealing the trajectory of targeted vessels in 3D. The SR-PCI method for systematic visualization of cerebral microvasculature holds considerable promise for wider application in life sciences, including 3D micro-imaging in experimental models of neurodevelopmental and vascular disorders.
KeywordPhase-contrast Human-brain Tomography Networks Microstructure Vessels Point Mice
Language英语
WOS IDWOS:000362346900001
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/25089
Collection中科院上海应用物理研究所2011-2018年
Corresponding AuthorXiao, B (reprint author), Cent S Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Hunan, Peoples R China.
Recommended Citation
GB/T 7714
Zhang, MQ,Zhou, L,Deng, QF,et al. Ultra-high-resolution 3D digitalized imaging of the cerebral angioarchitecture in rats using synchrotron radiation[J]. SCIENTIFIC REPORTS,2015,5:—.
APA Zhang, MQ.,Zhou, L.,Deng, QF.,Xie, YY.,Xiao, TQ.,...&Xiao, B .(2015).Ultra-high-resolution 3D digitalized imaging of the cerebral angioarchitecture in rats using synchrotron radiation.SCIENTIFIC REPORTS,5,—.
MLA Zhang, MQ,et al."Ultra-high-resolution 3D digitalized imaging of the cerebral angioarchitecture in rats using synchrotron radiation".SCIENTIFIC REPORTS 5(2015):—.
Files in This Item: Download All
File Name/Size DocType Version Access License
Ultra-high-resolutio(2605KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, MQ]'s Articles
[Zhou, L]'s Articles
[Deng, QF]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, MQ]'s Articles
[Zhou, L]'s Articles
[Deng, QF]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, MQ]'s Articles
[Zhou, L]'s Articles
[Deng, QF]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Ultra-high-resolution 3D digitalized imaging of the cerebral angioarchitecture in rats using synchrotron radiation.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.