Ultra-high-resolution 3D digitalized imaging of the cerebral angioarchitecture in rats using synchrotron radiation
Zhang, MQ; Zhou, L; Deng, QF; Xie, YY; Xiao, TQ; Cao, YZ; Zhang, JW; Chen, XM; Yin, XZ; Xiao, B; Xiao, B (reprint author), Cent S Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Hunan, Peoples R China.
2015
发表期刊SCIENTIFIC REPORTS
ISSN2045-2322
卷号5页码:
文章类型期刊文献
摘要The angioarchitecture is a fundamental aspect of brain development and physiology. However, available imaging tools are unsuited for non-destructive cerebral mapping of the functionally important three-dimensional (3D) vascular microstructures. To address this issue, we developed an ultra-high resolution 3D digitalized angioarchitectural map for rat brain, based on synchrotron radiation phase contrast imaging (SR-PCI) with pixel size of 5.92 mu m. This approach provides a systematic and detailed view of the cerebrovascular anatomy at the micrometer level without any need for contrast agents. From qualitative and quantitative perspectives, the present 3D data provide a considerable insight into the spatial vascular network for whole rodent brain, particularly for functionally important regions of interest, such as the hippocampus, pre-frontal cerebral cortex and the corpus striatum. We extended these results to synchrotron-based virtual micro-endoscopy, thus revealing the trajectory of targeted vessels in 3D. The SR-PCI method for systematic visualization of cerebral microvasculature holds considerable promise for wider application in life sciences, including 3D micro-imaging in experimental models of neurodevelopmental and vascular disorders.
关键词Phase-contrast Human-brain Tomography Networks Microstructure Vessels Point Mice
语种英语
WOS记录号WOS:000362346900001
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/25089
专题中科院上海应用物理研究所2011-2018年
通讯作者Xiao, B (reprint author), Cent S Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Hunan, Peoples R China.
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Zhang, MQ,Zhou, L,Deng, QF,et al. Ultra-high-resolution 3D digitalized imaging of the cerebral angioarchitecture in rats using synchrotron radiation[J]. SCIENTIFIC REPORTS,2015,5:—.
APA Zhang, MQ.,Zhou, L.,Deng, QF.,Xie, YY.,Xiao, TQ.,...&Xiao, B .(2015).Ultra-high-resolution 3D digitalized imaging of the cerebral angioarchitecture in rats using synchrotron radiation.SCIENTIFIC REPORTS,5,—.
MLA Zhang, MQ,et al."Ultra-high-resolution 3D digitalized imaging of the cerebral angioarchitecture in rats using synchrotron radiation".SCIENTIFIC REPORTS 5(2015):—.
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