Ultrasensitive Detection of Dual Cancer Biomarkers with Integrated CMOS-Compatible Nanowire Arrays
Lu, N; Gao, AR; Dai, PF; Mao, HJ; Zuo, XL; Fan, CH; Wang, YL; Li, T; Wang, YL (reprint author), Chinese Acad Sci, Shanghai Inst Microsyst & Informat Technol, Sci & Technol Microsyst Lab, Shanghai 200050, Peoples R China.
2015
发表期刊ANALYTICAL CHEMISTRY
ISSN0003-2700
卷号87期号:22页码:11203—11208
文章类型期刊文献
摘要A direct, rapid, highly sensitive and specific biosensor for detection of cancer biomarkers is desirable in early diagnosis and prognosis of cancer. However, the existing methods of detecting cancer biomarkers suffer from poor sensitivity as well as the requirement of enzymatic labeling or nanoparticle conjugations. Here, we proposed a two-channel PDMS microfluidic integrated CMOS-compatible silicon nanowire (SiNW) field-effect transistor arrays with potentially single use for label-free and ultrasensitive electrical detection of cancer biomarkers. The integrated nanowire arrays showed not only ultrahigh sensitivity of cytokeratin 19 fragment (CYFRA21-1) and prostate specific antigen (PSA) with detection to at least 1 fg/mL in buffer solution but also highly selectivity of discrimination from other similar cancer biomarkers. In addition, this method was used to detect both CYFRA21-1 and PSA real samples as low as 10 fg/mL in undiluted human serums. With its excellent properties and miniaturization, the integrated SiNW-FET device opens up great opportunities for a point-of-care test (POCT) for quick screening and early diagnosis of cancer and other complex diseases.
关键词Prostate-specific Antigen Label-free Detection Silicon-nanowire Electrical Detection Lung-cancer Sensor Arrays Dna Biosensor Amplification Transistor
语种英语
WOS记录号WOS:000365151000007
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/25090
专题中科院上海应用物理研究所2011-2018年
通讯作者Wang, YL (reprint author), Chinese Acad Sci, Shanghai Inst Microsyst & Informat Technol, Sci & Technol Microsyst Lab, Shanghai 200050, Peoples R China.
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Lu, N,Gao, AR,Dai, PF,et al. Ultrasensitive Detection of Dual Cancer Biomarkers with Integrated CMOS-Compatible Nanowire Arrays[J]. ANALYTICAL CHEMISTRY,2015,87(22):11203—11208.
APA Lu, N.,Gao, AR.,Dai, PF.,Mao, HJ.,Zuo, XL.,...&Wang, YL .(2015).Ultrasensitive Detection of Dual Cancer Biomarkers with Integrated CMOS-Compatible Nanowire Arrays.ANALYTICAL CHEMISTRY,87(22),11203—11208.
MLA Lu, N,et al."Ultrasensitive Detection of Dual Cancer Biomarkers with Integrated CMOS-Compatible Nanowire Arrays".ANALYTICAL CHEMISTRY 87.22(2015):11203—11208.
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