Acupuncture promotes mTOR-independent autophagic clearance of aggregation-prone proteins in mouse brain

doi:10.1038/srep19714

CAS OpenIR > 中科院上海应用物理研究所2011-2018年

	Acupuncture promotes mTOR-independent autophagic clearance of aggregation-prone proteins in mouse brain
	Tian, T; Sun, YH; Wu, HG; Pei, J; Zhang, J; Zhang, Y; Wang, L; Li, B; Wang, LH; Shi, JY; Hu, J; Fan, CH; Fan, CH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China.; Fan, CH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr,Shanghai Synchrotron Radiat Facil, Shanghai 201800, Peoples R China.
	2016
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	6 期号:-页码:—
文章类型	期刊文献
摘要	Acupuncture has historically been practiced to treat medical disorders by mechanically stimulating specific acupoints with fine needles. Despite its well-documented efficacy, its biological basis remains largely elusive. In this study, we found that mechanical stimulation at the acupoint of Yanglingquan (GB34) promoted the autophagic clearance of alpha-synuclein (alpha-syn), a well known aggregation-prone protein closely related to Parkinson's disease (PD), in the substantia nigra par compacta (SNpc) of the brain in a PD mouse model. We found the protein clearance arose from the activation of the autophagylysosome pathway (ALP) in a mammalian target of rapamycin (mTOR)-independent approach. Further, we observed the recovery in the activity of dopaminergic neurons in SNpc, and improvement in the motor function at the behavior level of PD mice. Whereas acupuncture and rapamycin, a chemical mTOR inhibitor, show comparable a-syn clearance and therapeutic effects in the PD mouse model, the latter adopts a distinctly different, mTOR-dependent, autophagy induction process. Due to this fundamental difference, acupuncture may circumvent adverse effects of the rapamycin treatment. The newly discovered connection between acupuncture and autophagy not only provides a new route to understanding the molecular mechanism of acupuncture but also sheds new light on cost-effective and safe therapy of neurodegenerative diseases.
关键词	Parkinsons-disease Neurodegenerative Disease Substantia-nigra Model Mptp Rapamycin Pathogenesis Toxicity Neurons Stress
DOI	10.1038/srep19714
收录类别	SCI
语种	英语
WOS记录号	WOS:000368789900002
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.sinap.ac.cn/handle/331007/25642
专题	中科院上海应用物理研究所2011-2018年
通讯作者	Fan, CH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China.; Fan, CH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr,Shanghai Synchrotron Radiat Facil, Shanghai 201800, Peoples R China.
推荐引用方式 GB/T 7714	Tian, T,Sun, YH,Wu, HG,et al. Acupuncture promotes mTOR-independent autophagic clearance of aggregation-prone proteins in mouse brain[J]. SCIENTIFIC REPORTS,2016,6(-):—.
APA	Tian, T.,Sun, YH.,Wu, HG.,Pei, J.,Zhang, J.,...&Fan, CH .(2016).Acupuncture promotes mTOR-independent autophagic clearance of aggregation-prone proteins in mouse brain.SCIENTIFIC REPORTS,6(-),—.
MLA	Tian, T,et al."Acupuncture promotes mTOR-independent autophagic clearance of aggregation-prone proteins in mouse brain".SCIENTIFIC REPORTS 6.-(2016):—.

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