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题名:
Acupuncture promotes mTOR-independent autophagic clearance of aggregation-prone proteins in mouse brain
作者: Tian, T; Sun, YH; Wu, HG; Pei, J; Zhang, J; Zhang, Y; Wang, L; Li, B; Wang, LH; Shi, JY; Hu, J; Fan, CH
刊名: SCIENTIFIC REPORTS
出版日期: 2016
卷号: 6, 期号:-, 页码:
关键词: PARKINSONS-DISEASE ; NEURODEGENERATIVE DISEASE ; SUBSTANTIA-NIGRA ; MODEL ; MPTP ; RAPAMYCIN ; PATHOGENESIS ; TOXICITY ; NEURONS ; STRESS
DOI: 10.1038/srep19714
通讯作者: Fan, CH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China. ; Fan, CH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr,Shanghai Synchrotron Radiat Facil, Shanghai 201800, Peoples R China.
文章类型: 期刊文献
英文摘要: Acupuncture has historically been practiced to treat medical disorders by mechanically stimulating specific acupoints with fine needles. Despite its well-documented efficacy, its biological basis remains largely elusive. In this study, we found that mechanical stimulation at the acupoint of Yanglingquan (GB34) promoted the autophagic clearance of alpha-synuclein (alpha-syn), a well known aggregation-prone protein closely related to Parkinson's disease (PD), in the substantia nigra par compacta (SNpc) of the brain in a PD mouse model. We found the protein clearance arose from the activation of the autophagylysosome pathway (ALP) in a mammalian target of rapamycin (mTOR)-independent approach. Further, we observed the recovery in the activity of dopaminergic neurons in SNpc, and improvement in the motor function at the behavior level of PD mice. Whereas acupuncture and rapamycin, a chemical mTOR inhibitor, show comparable a-syn clearance and therapeutic effects in the PD mouse model, the latter adopts a distinctly different, mTOR-dependent, autophagy induction process. Due to this fundamental difference, acupuncture may circumvent adverse effects of the rapamycin treatment. The newly discovered connection between acupuncture and autophagy not only provides a new route to understanding the molecular mechanism of acupuncture but also sheds new light on cost-effective and safe therapy of neurodegenerative diseases.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000368789900002
ISSN号: 2045-2322
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/25642
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

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Recommended Citation:
Tian, T,Sun, YH,Wu, HG,et al. Acupuncture promotes mTOR-independent autophagic clearance of aggregation-prone proteins in mouse brain[J]. SCIENTIFIC REPORTS,2016-01-01,6(-):—.
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