Acupuncture promotes mTOR-independent autophagic clearance of aggregation-prone proteins in mouse brain
Tian, T; Sun, YH; Wu, HG; Pei, J; Zhang, J; Zhang, Y; Wang, L; Li, B; Wang, LH; Shi, JY; Hu, J; Fan, CH; Fan, CH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China.; Fan, CH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr,Shanghai Synchrotron Radiat Facil, Shanghai 201800, Peoples R China.
2016
发表期刊SCIENTIFIC REPORTS
ISSN2045-2322
卷号6期号:-页码:
文章类型期刊文献
摘要Acupuncture has historically been practiced to treat medical disorders by mechanically stimulating specific acupoints with fine needles. Despite its well-documented efficacy, its biological basis remains largely elusive. In this study, we found that mechanical stimulation at the acupoint of Yanglingquan (GB34) promoted the autophagic clearance of alpha-synuclein (alpha-syn), a well known aggregation-prone protein closely related to Parkinson's disease (PD), in the substantia nigra par compacta (SNpc) of the brain in a PD mouse model. We found the protein clearance arose from the activation of the autophagylysosome pathway (ALP) in a mammalian target of rapamycin (mTOR)-independent approach. Further, we observed the recovery in the activity of dopaminergic neurons in SNpc, and improvement in the motor function at the behavior level of PD mice. Whereas acupuncture and rapamycin, a chemical mTOR inhibitor, show comparable a-syn clearance and therapeutic effects in the PD mouse model, the latter adopts a distinctly different, mTOR-dependent, autophagy induction process. Due to this fundamental difference, acupuncture may circumvent adverse effects of the rapamycin treatment. The newly discovered connection between acupuncture and autophagy not only provides a new route to understanding the molecular mechanism of acupuncture but also sheds new light on cost-effective and safe therapy of neurodegenerative diseases.
关键词Parkinsons-disease Neurodegenerative Disease Substantia-nigra Model Mptp Rapamycin Pathogenesis Toxicity Neurons Stress
DOI10.1038/srep19714
收录类别SCI
语种英语
WOS记录号WOS:000368789900002
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/25642
专题中科院上海应用物理研究所2011-2018年
通讯作者Fan, CH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China.; Fan, CH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr,Shanghai Synchrotron Radiat Facil, Shanghai 201800, Peoples R China.
推荐引用方式
GB/T 7714
Tian, T,Sun, YH,Wu, HG,et al. Acupuncture promotes mTOR-independent autophagic clearance of aggregation-prone proteins in mouse brain[J]. SCIENTIFIC REPORTS,2016,6(-):—.
APA Tian, T.,Sun, YH.,Wu, HG.,Pei, J.,Zhang, J.,...&Fan, CH .(2016).Acupuncture promotes mTOR-independent autophagic clearance of aggregation-prone proteins in mouse brain.SCIENTIFIC REPORTS,6(-),—.
MLA Tian, T,et al."Acupuncture promotes mTOR-independent autophagic clearance of aggregation-prone proteins in mouse brain".SCIENTIFIC REPORTS 6.-(2016):—.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Acupuncture promotes(1669KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Tian, T]的文章
[Sun, YH]的文章
[Wu, HG]的文章
百度学术
百度学术中相似的文章
[Tian, T]的文章
[Sun, YH]的文章
[Wu, HG]的文章
必应学术
必应学术中相似的文章
[Tian, T]的文章
[Sun, YH]的文章
[Wu, HG]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Acupuncture promotes mTOR-independent autophagic clearance of aggregation-prone proteins in mouse brain.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。