An electrochemical immunosensor for quantitative detection of ficolin-3

doi:10.1088/0957-4484/27/25/254003

CAS OpenIR > 中科院上海应用物理研究所2011-2018年

	An electrochemical immunosensor for quantitative detection of ficolin-3
	San, LL; Zeng, DD; Song, SP; Zuo, XL; Zhang, H; Wang, CG; Wu, JR; Mi, XQ; Wu, JR (reprint author), Chinese Acad Sci, Shanghai Adv Res Inst, Lab Syst Biol, Shanghai 201210, Peoples R China.; Wu, JR (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai 200031, Peoples R China.
	2016
Source Publication	NANOTECHNOLOGY
ISSN	0957-4484
Volume	27 Issue:25 Pages:—
Subtype	期刊文献
Abstract	Diabetes mellitus (DM) is one of the most common metabolic disorders in the world, of which more than 90% is type-2 diabetes mellitus (T2DM). There is a rather urgent need for reliable, sensitive and quick detection techniques in clinical application of T2DM. Ficolin-3 is a potential biomarker of T2DM, because serum ficolin-3 levels are associated with insulin resistance and predict the incidence of T2DM. Herein, a sandwich-type electrochemical immunosensor was developed for the detection of ficolin-3 in human serum. Cyclic voltammetry and the amperometric current versus time were used to characterize the performance of the immunosensor. Under optimal conditions, the detection limitation of ficolin-3 was 100 ng ml(-1) and the linear dynamic range was between 2 and 50 mu g ml(-1). The method has ideal accuracy, excellent stability and selectivity and has wide application prospects in clinical research.
Keyword	Systemic-lupus-erythematosus Immune Component Ficolin-3 Type-2 Diabetes-mellitus Glassy-carbon Electrode Hakata Antigen Insulin-resistance Competitive Elisa Aflatoxin B-1 Serum-levels Identification
DOI	10.1088/0957-4484/27/25/254003
Indexed By	SCI
Language	英语
WOS ID	WOS:000377064200004
Citation statistics	Cited Times:3[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.sinap.ac.cn/handle/331007/25643
Collection	中科院上海应用物理研究所2011-2018年
Corresponding Author	Wu, JR (reprint author), Chinese Acad Sci, Shanghai Adv Res Inst, Lab Syst Biol, Shanghai 201210, Peoples R China.; Wu, JR (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai 200031, Peoples R China.
Recommended Citation GB/T 7714	San, LL,Zeng, DD,Song, SP,et al. An electrochemical immunosensor for quantitative detection of ficolin-3[J]. NANOTECHNOLOGY,2016,27(25):—.
APA	San, LL.,Zeng, DD.,Song, SP.,Zuo, XL.,Zhang, H.,...&Wu, JR .(2016).An electrochemical immunosensor for quantitative detection of ficolin-3.NANOTECHNOLOGY,27(25),—.
MLA	San, LL,et al."An electrochemical immunosensor for quantitative detection of ficolin-3".NANOTECHNOLOGY 27.25(2016):—.

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