An electrochemical immunosensor for quantitative detection of ficolin-3
San, LL; Zeng, DD; Song, SP; Zuo, XL; Zhang, H; Wang, CG; Wu, JR; Mi, XQ; Wu, JR (reprint author), Chinese Acad Sci, Shanghai Adv Res Inst, Lab Syst Biol, Shanghai 201210, Peoples R China.; Wu, JR (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai 200031, Peoples R China.
2016
发表期刊NANOTECHNOLOGY
ISSN0957-4484
卷号27期号:25页码:
文章类型期刊文献
摘要Diabetes mellitus (DM) is one of the most common metabolic disorders in the world, of which more than 90% is type-2 diabetes mellitus (T2DM). There is a rather urgent need for reliable, sensitive and quick detection techniques in clinical application of T2DM. Ficolin-3 is a potential biomarker of T2DM, because serum ficolin-3 levels are associated with insulin resistance and predict the incidence of T2DM. Herein, a sandwich-type electrochemical immunosensor was developed for the detection of ficolin-3 in human serum. Cyclic voltammetry and the amperometric current versus time were used to characterize the performance of the immunosensor. Under optimal conditions, the detection limitation of ficolin-3 was 100 ng ml(-1) and the linear dynamic range was between 2 and 50 mu g ml(-1). The method has ideal accuracy, excellent stability and selectivity and has wide application prospects in clinical research.
关键词Systemic-lupus-erythematosus Immune Component Ficolin-3 Type-2 Diabetes-mellitus Glassy-carbon Electrode Hakata Antigen Insulin-resistance Competitive Elisa Aflatoxin B-1 Serum-levels Identification
DOI10.1088/0957-4484/27/25/254003
收录类别SCI
语种英语
WOS记录号WOS:000377064200004
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/25643
专题中科院上海应用物理研究所2011-2018年
通讯作者Wu, JR (reprint author), Chinese Acad Sci, Shanghai Adv Res Inst, Lab Syst Biol, Shanghai 201210, Peoples R China.; Wu, JR (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai 200031, Peoples R China.
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GB/T 7714
San, LL,Zeng, DD,Song, SP,et al. An electrochemical immunosensor for quantitative detection of ficolin-3[J]. NANOTECHNOLOGY,2016,27(25):—.
APA San, LL.,Zeng, DD.,Song, SP.,Zuo, XL.,Zhang, H.,...&Wu, JR .(2016).An electrochemical immunosensor for quantitative detection of ficolin-3.NANOTECHNOLOGY,27(25),—.
MLA San, LL,et al."An electrochemical immunosensor for quantitative detection of ficolin-3".NANOTECHNOLOGY 27.25(2016):—.
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