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| An electrochemical immunosensor for quantitative detection of ficolin-3 | |
| San, LL; Zeng, DD; Song, SP; Zuo, XL; Zhang, H; Wang, CG; Wu, JR; Mi, XQ; Wu, JR (reprint author), Chinese Acad Sci, Shanghai Adv Res Inst, Lab Syst Biol, Shanghai 201210, Peoples R China.; Wu, JR (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai 200031, Peoples R China. | |
| 2016 | |
| Source Publication | NANOTECHNOLOGY
 |
| ISSN | 0957-4484 |
| Volume | 27Issue:25Pages:— |
| Subtype | 期刊文献 |
| Abstract | Diabetes mellitus (DM) is one of the most common metabolic disorders in the world, of which more than 90% is type-2 diabetes mellitus (T2DM). There is a rather urgent need for reliable, sensitive and quick detection techniques in clinical application of T2DM. Ficolin-3 is a potential biomarker of T2DM, because serum ficolin-3 levels are associated with insulin resistance and predict the incidence of T2DM. Herein, a sandwich-type electrochemical immunosensor was developed for the detection of ficolin-3 in human serum. Cyclic voltammetry and the amperometric current versus time were used to characterize the performance of the immunosensor. Under optimal conditions, the detection limitation of ficolin-3 was 100 ng ml(-1) and the linear dynamic range was between 2 and 50 mu g ml(-1). The method has ideal accuracy, excellent stability and selectivity and has wide application prospects in clinical research. |
| Keyword | Systemic-lupus-erythematosus Immune Component Ficolin-3 Type-2 Diabetes-mellitus Glassy-carbon Electrode Hakata Antigen Insulin-resistance Competitive Elisa Aflatoxin B-1 Serum-levels Identification |
| DOI | 10.1088/0957-4484/27/25/254003 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000377064200004 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/25643 |
| Collection | 中科院上海应用物理研究所2011-2020年 |
| Corresponding Author | Wu, JR (reprint author), Chinese Acad Sci, Shanghai Adv Res Inst, Lab Syst Biol, Shanghai 201210, Peoples R China.; Wu, JR (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai 200031, Peoples R China. |
| Recommended Citation GB/T 7714 | San, LL,Zeng, DD,Song, SP,et al. An electrochemical immunosensor for quantitative detection of ficolin-3[J]. NANOTECHNOLOGY,2016,27(25):—. |
| APA | San, LL.,Zeng, DD.,Song, SP.,Zuo, XL.,Zhang, H.,...&Wu, JR .(2016).An electrochemical immunosensor for quantitative detection of ficolin-3.NANOTECHNOLOGY,27(25),—. |
| MLA | San, LL,et al."An electrochemical immunosensor for quantitative detection of ficolin-3".NANOTECHNOLOGY 27.25(2016):—. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| An electrochemical i（1501KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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