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CAS OpenIR  > 中科院上海应用物理研究所2011-2017年  > 期刊论文
题名:
An electrochemical immunosensor for quantitative detection of ficolin-3
作者: San, LL; Zeng, DD; Song, SP; Zuo, XL; Zhang, H; Wang, CG; Wu, JR; Mi, XQ
刊名: NANOTECHNOLOGY
出版日期: 2016
卷号: 27, 期号:25, 页码:
关键词: SYSTEMIC-LUPUS-ERYTHEMATOSUS ; IMMUNE COMPONENT FICOLIN-3 ; TYPE-2 DIABETES-MELLITUS ; GLASSY-CARBON ELECTRODE ; HAKATA ANTIGEN ; INSULIN-RESISTANCE ; COMPETITIVE ELISA ; AFLATOXIN B-1 ; SERUM-LEVELS ; IDENTIFICATION
DOI: 10.1088/0957-4484/27/25/254003
通讯作者: Wu, JR (reprint author), Chinese Acad Sci, Shanghai Adv Res Inst, Lab Syst Biol, Shanghai 201210, Peoples R China. ; Wu, JR (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai 200031, Peoples R China.
文章类型: 期刊文献
英文摘要: Diabetes mellitus (DM) is one of the most common metabolic disorders in the world, of which more than 90% is type-2 diabetes mellitus (T2DM). There is a rather urgent need for reliable, sensitive and quick detection techniques in clinical application of T2DM. Ficolin-3 is a potential biomarker of T2DM, because serum ficolin-3 levels are associated with insulin resistance and predict the incidence of T2DM. Herein, a sandwich-type electrochemical immunosensor was developed for the detection of ficolin-3 in human serum. Cyclic voltammetry and the amperometric current versus time were used to characterize the performance of the immunosensor. Under optimal conditions, the detection limitation of ficolin-3 was 100 ng ml(-1) and the linear dynamic range was between 2 and 50 mu g ml(-1). The method has ideal accuracy, excellent stability and selectivity and has wide application prospects in clinical research.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000377064200004
ISSN号: 0957-4484
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/25643
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

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Recommended Citation:
San, LL,Zeng, DD,Song, SP,et al. An electrochemical immunosensor for quantitative detection of ficolin-3[J]. NANOTECHNOLOGY,2016-01-01,27(25):—.
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