CAS OpenIR  > 中科院上海应用物理研究所2011-2018年
DNA nanotechnology-enabled biosensors
Chao, J; Zhu, D; Zhang, YN; Wang, LH; Fan, CH; Fan, CH (reprint author), Chinese Acad Sci, Div Phys Biol, Shanghai 201800, Peoples R China.
2016
Source PublicationBIOSENSORS & BIOELECTRONICS
ISSN0956-5663
Volume76Issue:-Pages:68—79
Subtype期刊文献
AbstractBiosensors employ biological molecules to recognize the target and utilize output elements which can translate the biorecognition event into electrical, optical or mass-sensitive signals to determine the quantities of the target. DNA-based biosensors, as a sub-field to biosensor, utilize DNA strands with short oligonucleotides as probes for target recognition. Although DNA-based biosensors have offered a promising alternative for fast, simple and cheap detection of target molecules, there still exist key challenges including poor stability and reproducibility that hinder their competition with the current gold standard for DNA assays. By exploiting the self-recognition properties of DNA molecules, researchers have dedicated to make versatile DNA nanostructures in a highly rigid, controllable and fiinctionalized manner, which offers unprecedented opportunities for developing DNA-based biosensors. In this review, we will briefly introduce the recent advances on design and fabrication of static and dynamic DNA nanostructures, and summarize their applications for fabrication and functionalization of DNA-based biosensors. (C) 2015 Elsevier B.V. All rights reserved.
KeywordRolling-circle Amplification Hybridization Chain-reaction Sequence-specific Detection Prostate-specific Antigen Create Nanoscale Shapes Nucleic-acids Photoelectrochemical Biosensor Electrochemical Biosensor Intracellular Delivery Branched Junctions
DOI10.1016/j.bios.2015.07.007
Indexed BySCI
Language英语
WOS IDWOS:000364895000007
Citation statistics
Cited Times:47[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/25689
Collection中科院上海应用物理研究所2011-2018年
Corresponding AuthorFan, CH (reprint author), Chinese Acad Sci, Div Phys Biol, Shanghai 201800, Peoples R China.
Recommended Citation
GB/T 7714
Chao, J,Zhu, D,Zhang, YN,et al. DNA nanotechnology-enabled biosensors[J]. BIOSENSORS & BIOELECTRONICS,2016,76(-):68—79.
APA Chao, J,Zhu, D,Zhang, YN,Wang, LH,Fan, CH,&Fan, CH .(2016).DNA nanotechnology-enabled biosensors.BIOSENSORS & BIOELECTRONICS,76(-),68—79.
MLA Chao, J,et al."DNA nanotechnology-enabled biosensors".BIOSENSORS & BIOELECTRONICS 76.-(2016):68—79.
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