CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
DNA nanotechnology-enabled biosensors
Chao, J; Zhu, D; Zhang, YN; Wang, LH; Fan, CH; Fan, CH (reprint author), Chinese Acad Sci, Div Phys Biol, Shanghai 201800, Peoples R China.
AbstractBiosensors employ biological molecules to recognize the target and utilize output elements which can translate the biorecognition event into electrical, optical or mass-sensitive signals to determine the quantities of the target. DNA-based biosensors, as a sub-field to biosensor, utilize DNA strands with short oligonucleotides as probes for target recognition. Although DNA-based biosensors have offered a promising alternative for fast, simple and cheap detection of target molecules, there still exist key challenges including poor stability and reproducibility that hinder their competition with the current gold standard for DNA assays. By exploiting the self-recognition properties of DNA molecules, researchers have dedicated to make versatile DNA nanostructures in a highly rigid, controllable and fiinctionalized manner, which offers unprecedented opportunities for developing DNA-based biosensors. In this review, we will briefly introduce the recent advances on design and fabrication of static and dynamic DNA nanostructures, and summarize their applications for fabrication and functionalization of DNA-based biosensors. (C) 2015 Elsevier B.V. All rights reserved.
KeywordRolling-circle Amplification Hybridization Chain-reaction Sequence-specific Detection Prostate-specific Antigen Create Nanoscale Shapes Nucleic-acids Photoelectrochemical Biosensor Electrochemical Biosensor Intracellular Delivery Branched Junctions
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WOS IDWOS:000364895000007
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Document Type期刊论文
Corresponding AuthorFan, CH (reprint author), Chinese Acad Sci, Div Phys Biol, Shanghai 201800, Peoples R China.
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GB/T 7714
Chao, J,Zhu, D,Zhang, YN,et al. DNA nanotechnology-enabled biosensors[J]. BIOSENSORS & BIOELECTRONICS,2016,76(-):68—79.
APA Chao, J,Zhu, D,Zhang, YN,Wang, LH,Fan, CH,&Fan, CH .(2016).DNA nanotechnology-enabled biosensors.BIOSENSORS & BIOELECTRONICS,76(-),68—79.
MLA Chao, J,et al."DNA nanotechnology-enabled biosensors".BIOSENSORS & BIOELECTRONICS 76.-(2016):68—79.
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