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Dual-Target Electrochemical Biosensing Based on DNA Structural Switching on Gold Nanoparticle-Decorated MoS2 Nanosheets
Su, S; Sun, HF; Cao, WF; Chao, J; Peng, HZ; Zuo, XL; Yuwen, LH; Fan, CH; Wang, LH; Wang, LH (reprint author), Nanjing Univ Posts & Telecommun, Natl Synerget Innovat Ctr Adv Mat SICAM, Key Lab Organ Elect & Informat Displays, 9 Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China.; Wang, LH (reprint author), Nanjing Univ Posts & Telecommun, Natl Synerget Innovat Ctr Adv Mat SICAM, Inst Adv Mat, 9 Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China.
2016
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume8Issue:11Pages:6826—6833
Subtype期刊文献
AbstractA MoS2-based electrochemical aptasensor has been developed for the simultaneous detection of thrombin and adenosine triphosphate (ATP) based on gold nano particles-decorated MoS2 (AuNPs-MoS2) nanocomposites. Two different aptamer probes labeled with redox tags were simultaneously immobilized on an AuNPs-MoS2 film modified electrode via Au-S bonds. The aptamers presented structural switches with the addition of target molecules (thrombin and ATP), resulting in methylene blue (MB) far from or ferrocene (Fc) close to the electrode surface. Therefore, a dual signaling detection strategy was developed, which featured both "signal-on" and "signal-off' elements in the detection system because of the target-induced structure switching. This proposed aptasensor could simultaneously determine ATP and thrombin as low as 0.74 nM ATP and 0.0012 nM thrombin with high selectivity, respectively. In addition, thrombin and ATP could act as inputs to activate an AND logic gate.
KeywordSingle-layer Mos2 Molybdenum-disulfide Adenosine-triphosphate Signal Amplification Sensitive Detection Thrombin Detection Graphene Oxide Aptamer Label Aptasensor
DOI10.1021/acsami.5b12833
Indexed BySCI
Language英语
WOS IDWOS:000372946600007
Citation statistics
Cited Times:62[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/25691
Collection中科院上海应用物理研究所2011-2018年
Corresponding AuthorSu, S; Wang, LH (reprint author), Nanjing Univ Posts & Telecommun, Natl Synerget Innovat Ctr Adv Mat SICAM, Key Lab Organ Elect & Informat Displays, 9 Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China.; Wang, LH (reprint author), Nanjing Univ Posts & Telecommun, Natl Synerget Innovat Ctr Adv Mat SICAM, Inst Adv Mat, 9 Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China.
Recommended Citation
GB/T 7714
Su, S,Sun, HF,Cao, WF,et al. Dual-Target Electrochemical Biosensing Based on DNA Structural Switching on Gold Nanoparticle-Decorated MoS2 Nanosheets[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(11):6826—6833.
APA Su, S.,Sun, HF.,Cao, WF.,Chao, J.,Peng, HZ.,...&Wang, LH .(2016).Dual-Target Electrochemical Biosensing Based on DNA Structural Switching on Gold Nanoparticle-Decorated MoS2 Nanosheets.ACS APPLIED MATERIALS & INTERFACES,8(11),6826—6833.
MLA Su, S,et al."Dual-Target Electrochemical Biosensing Based on DNA Structural Switching on Gold Nanoparticle-Decorated MoS2 Nanosheets".ACS APPLIED MATERIALS & INTERFACES 8.11(2016):6826—6833.
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