Dual-Target Electrochemical Biosensing Based on DNA Structural Switching on Gold Nanoparticle-Decorated MoS2 Nanosheets

doi:10.1021/acsami.5b12833

CAS OpenIR > 中科院上海应用物理研究所2011-2018年

	Dual-Target Electrochemical Biosensing Based on DNA Structural Switching on Gold Nanoparticle-Decorated MoS2 Nanosheets
	Su, S; Sun, HF; Cao, WF; Chao, J; Peng, HZ; Zuo, XL; Yuwen, LH; Fan, CH; Wang, LH; Wang, LH (reprint author), Nanjing Univ Posts & Telecommun, Natl Synerget Innovat Ctr Adv Mat SICAM, Key Lab Organ Elect & Informat Displays, 9 Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China.; Wang, LH (reprint author), Nanjing Univ Posts & Telecommun, Natl Synerget Innovat Ctr Adv Mat SICAM, Inst Adv Mat, 9 Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China.
	2016
Source Publication	ACS APPLIED MATERIALS & INTERFACES
ISSN	1944-8244
Volume	8 Issue:11 Pages:6826—6833
Subtype	期刊文献
Abstract	A MoS2-based electrochemical aptasensor has been developed for the simultaneous detection of thrombin and adenosine triphosphate (ATP) based on gold nano particles-decorated MoS2 (AuNPs-MoS2) nanocomposites. Two different aptamer probes labeled with redox tags were simultaneously immobilized on an AuNPs-MoS2 film modified electrode via Au-S bonds. The aptamers presented structural switches with the addition of target molecules (thrombin and ATP), resulting in methylene blue (MB) far from or ferrocene (Fc) close to the electrode surface. Therefore, a dual signaling detection strategy was developed, which featured both "signal-on" and "signal-off' elements in the detection system because of the target-induced structure switching. This proposed aptasensor could simultaneously determine ATP and thrombin as low as 0.74 nM ATP and 0.0012 nM thrombin with high selectivity, respectively. In addition, thrombin and ATP could act as inputs to activate an AND logic gate.
Keyword	Single-layer Mos2 Molybdenum-disulfide Adenosine-triphosphate Signal Amplification Sensitive Detection Thrombin Detection Graphene Oxide Aptamer Label Aptasensor
DOI	10.1021/acsami.5b12833
Indexed By	SCI
Language	英语
WOS ID	WOS:000372946600007
Citation statistics	Cited Times:66[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.sinap.ac.cn/handle/331007/25691
Collection	中科院上海应用物理研究所2011-2018年
Corresponding Author	Su, S; Wang, LH (reprint author), Nanjing Univ Posts & Telecommun, Natl Synerget Innovat Ctr Adv Mat SICAM, Key Lab Organ Elect & Informat Displays, 9 Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China.; Wang, LH (reprint author), Nanjing Univ Posts & Telecommun, Natl Synerget Innovat Ctr Adv Mat SICAM, Inst Adv Mat, 9 Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China.
Recommended Citation GB/T 7714	Su, S,Sun, HF,Cao, WF,et al. Dual-Target Electrochemical Biosensing Based on DNA Structural Switching on Gold Nanoparticle-Decorated MoS2 Nanosheets[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(11):6826—6833.
APA	Su, S.,Sun, HF.,Cao, WF.,Chao, J.,Peng, HZ.,...&Wang, LH .(2016).Dual-Target Electrochemical Biosensing Based on DNA Structural Switching on Gold Nanoparticle-Decorated MoS2 Nanosheets.ACS APPLIED MATERIALS & INTERFACES,8(11),6826—6833.
MLA	Su, S,et al."Dual-Target Electrochemical Biosensing Based on DNA Structural Switching on Gold Nanoparticle-Decorated MoS2 Nanosheets".ACS APPLIED MATERIALS & INTERFACES 8.11(2016):6826—6833.

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