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CAS OpenIR  > 中科院上海应用物理研究所2011-2017年  > 期刊论文
题名:
Dual-Target Electrochemical Biosensing Based on DNA Structural Switching on Gold Nanoparticle-Decorated MoS2 Nanosheets
作者: Su, S; Sun, HF; Cao, WF; Chao, J; Peng, HZ; Zuo, XL; Yuwen, LH; Fan, CH; Wang, LH
刊名: ACS APPLIED MATERIALS & INTERFACES
出版日期: 2016
卷号: 8, 期号:11, 页码:6826—6833
关键词: SINGLE-LAYER MOS2 ; MOLYBDENUM-DISULFIDE ; ADENOSINE-TRIPHOSPHATE ; SIGNAL AMPLIFICATION ; SENSITIVE DETECTION ; THROMBIN DETECTION ; GRAPHENE OXIDE ; APTAMER ; LABEL ; APTASENSOR
DOI: 10.1021/acsami.5b12833
通讯作者: Su, S ; Wang, LH (reprint author), Nanjing Univ Posts & Telecommun, Natl Synerget Innovat Ctr Adv Mat SICAM, Key Lab Organ Elect & Informat Displays, 9 Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China. ; Su, S ; Wang, LH (reprint author), Nanjing Univ Posts & Telecommun, Natl Synerget Innovat Ctr Adv Mat SICAM, Inst Adv Mat, 9 Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China.
文章类型: 期刊文献
英文摘要: A MoS2-based electrochemical aptasensor has been developed for the simultaneous detection of thrombin and adenosine triphosphate (ATP) based on gold nano particles-decorated MoS2 (AuNPs-MoS2) nanocomposites. Two different aptamer probes labeled with redox tags were simultaneously immobilized on an AuNPs-MoS2 film modified electrode via Au-S bonds. The aptamers presented structural switches with the addition of target molecules (thrombin and ATP), resulting in methylene blue (MB) far from or ferrocene (Fc) close to the electrode surface. Therefore, a dual signaling detection strategy was developed, which featured both "signal-on" and "signal-off' elements in the detection system because of the target-induced structure switching. This proposed aptasensor could simultaneously determine ATP and thrombin as low as 0.74 nM ATP and 0.0012 nM thrombin with high selectivity, respectively. In addition, thrombin and ATP could act as inputs to activate an AND logic gate.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000372946600007
ISSN号: 1944-8244
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/25691
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

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Recommended Citation:
Su, S,Sun, HF,Cao, WF,et al. Dual-Target Electrochemical Biosensing Based on DNA Structural Switching on Gold Nanoparticle-Decorated MoS2 Nanosheets[J]. ACS APPLIED MATERIALS & INTERFACES,2016-01-01,8(11):6826—6833.
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