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| Effect of C-5 position on the photochemical properties and phototoxicity of antofloxacin and levofloxacin: A stable and transient study | |
| Zhao, JF; Liu, YC; Jiang, XX; Guo, P; Xu, YL; Zhang, P; Ji, TY; Lin, ZS; Wang, WF; Wang, WF (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China.; Lin, ZS (reprint author), Chinese Acad Sci, Tech Inst Phys & Chem, Ctr Crystal R&D, Key Lab Funct Crystals & Laser Technol, Beijing 100190, Peoples R China. | |
| 2016 | |
| Source Publication | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
 |
| ISSN | 1011-1344 |
| Volume | 155Issue:-Pages:122—129 |
| Subtype | 期刊文献 |
| Abstract | The photochemistry of two structure-related fluoroquinolones (FQs), antofloxacin (ANT) and levofloxacin (LEV), was studied in aqueous solution using stable and transient methods. The properties for energy transfer and electron transfer of these two FQs were also studied. The transient absorption spectra of FQs were observed, and transient species were assigned. The LEV triplet state ((LEV)-L-3*) spectra (lambda(max) = 610 nm) were determined, whereas the transient absorption of ANT could not be observed. The decay rate constant of (LEV)-L-3* via unimolecular attenuation, self-quenching, and quenching by oxygen was 32 x 10(5) s(-1), 6.72 x 10(8) M-1 s(-1), and 1.01 x 10(9) M-1 s(-1), respectively. A reasonable diagram showing the decay of (1)FQs* consisting of various substituents at the C-5 position was proposed. The phototoxicity of LEV and ANT was investigated and compared. Insertion of an amino group at the C-5 position made ANT relatively photostable and non-phototoxic compared with LEV. (C) 2015 Elsevier B.V. All rights reserved. |
| Keyword | Neutral Aqueous-solution Fluoroquinolone Antibiotics Mycobacterium-tuberculosis Streptococcus-pneumoniae Quinolone Antibacterials Spectroscopic Properties Photophysical Properties Drug Lomefloxacin Electron-transfer Steady-state |
| DOI | 10.1016/j.jphotobiol.2015.12.004 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000370090700017 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/25693 |
| Collection | 中科院上海应用物理研究所2011-2019年 |
| Corresponding Author | Wang, WF (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China.; Lin, ZS (reprint author), Chinese Acad Sci, Tech Inst Phys & Chem, Ctr Crystal R&D, Key Lab Funct Crystals & Laser Technol, Beijing 100190, Peoples R China. |
| Recommended Citation GB/T 7714 | Zhao, JF,Liu, YC,Jiang, XX,et al. Effect of C-5 position on the photochemical properties and phototoxicity of antofloxacin and levofloxacin: A stable and transient study[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,2016,155(-):122—129. |
| APA | Zhao, JF.,Liu, YC.,Jiang, XX.,Guo, P.,Xu, YL.,...&Lin, ZS .(2016).Effect of C-5 position on the photochemical properties and phototoxicity of antofloxacin and levofloxacin: A stable and transient study.JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,155(-),122—129. |
| MLA | Zhao, JF,et al."Effect of C-5 position on the photochemical properties and phototoxicity of antofloxacin and levofloxacin: A stable and transient study".JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 155.-(2016):122—129. |
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| Effect of C-5 positi（1121KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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