Effect of C-5 position on the photochemical properties and phototoxicity of antofloxacin and levofloxacin: A stable and transient study

doi:10.1016/j.jphotobiol.2015.12.004

CAS OpenIR > 中科院上海应用物理研究所2011-2018年

	Effect of C-5 position on the photochemical properties and phototoxicity of antofloxacin and levofloxacin: A stable and transient study
	Zhao, JF; Liu, YC; Jiang, XX; Guo, P; Xu, YL; Zhang, P; Ji, TY; Lin, ZS; Wang, WF; Wang, WF (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China.; Lin, ZS (reprint author), Chinese Acad Sci, Tech Inst Phys & Chem, Ctr Crystal R&D, Key Lab Funct Crystals & Laser Technol, Beijing 100190, Peoples R China.
	2016
发表期刊	JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
ISSN	1011-1344
卷号	155 期号:-页码:122—129
文章类型	期刊文献
摘要	The photochemistry of two structure-related fluoroquinolones (FQs), antofloxacin (ANT) and levofloxacin (LEV), was studied in aqueous solution using stable and transient methods. The properties for energy transfer and electron transfer of these two FQs were also studied. The transient absorption spectra of FQs were observed, and transient species were assigned. The LEV triplet state ((LEV)-L-3) spectra (lambda(max) = 610 nm) were determined, whereas the transient absorption of ANT could not be observed. The decay rate constant of (LEV)-L-3 via unimolecular attenuation, self-quenching, and quenching by oxygen was 32 x 10(5) s(-1), 6.72 x 10(8) M-1 s(-1), and 1.01 x 10(9) M-1 s(-1), respectively. A reasonable diagram showing the decay of (1)FQs* consisting of various substituents at the C-5 position was proposed. The phototoxicity of LEV and ANT was investigated and compared. Insertion of an amino group at the C-5 position made ANT relatively photostable and non-phototoxic compared with LEV. (C) 2015 Elsevier B.V. All rights reserved.
关键词	Neutral Aqueous-solution Fluoroquinolone Antibiotics Mycobacterium-tuberculosis Streptococcus-pneumoniae Quinolone Antibacterials Spectroscopic Properties Photophysical Properties Drug Lomefloxacin Electron-transfer Steady-state
DOI	10.1016/j.jphotobiol.2015.12.004
收录类别	SCI
语种	英语
WOS记录号	WOS:000370090700017
引用统计
文献类型	期刊论文
条目标识符	http://ir.sinap.ac.cn/handle/331007/25693
专题	中科院上海应用物理研究所2011-2018年
通讯作者	Wang, WF (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China.; Lin, ZS (reprint author), Chinese Acad Sci, Tech Inst Phys & Chem, Ctr Crystal R&D, Key Lab Funct Crystals & Laser Technol, Beijing 100190, Peoples R China.
推荐引用方式 GB/T 7714	Zhao, JF,Liu, YC,Jiang, XX,et al. Effect of C-5 position on the photochemical properties and phototoxicity of antofloxacin and levofloxacin: A stable and transient study[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,2016,155(-):122—129.
APA	Zhao, JF.,Liu, YC.,Jiang, XX.,Guo, P.,Xu, YL.,...&Lin, ZS .(2016).Effect of C-5 position on the photochemical properties and phototoxicity of antofloxacin and levofloxacin: A stable and transient study.JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,155(-),122—129.
MLA	Zhao, JF,et al."Effect of C-5 position on the photochemical properties and phototoxicity of antofloxacin and levofloxacin: A stable and transient study".JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 155.-(2016):122—129.

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