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Effect of C-5 position on the photochemical properties and phototoxicity of antofloxacin and levofloxacin: A stable and transient study
Zhao, JF; Liu, YC; Jiang, XX; Guo, P; Xu, YL; Zhang, P; Ji, TY; Lin, ZS; Wang, WF; Wang, WF (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China.; Lin, ZS (reprint author), Chinese Acad Sci, Tech Inst Phys & Chem, Ctr Crystal R&D, Key Lab Funct Crystals & Laser Technol, Beijing 100190, Peoples R China.
2016
Source PublicationJOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
ISSN1011-1344
Volume155Issue:-Pages:122—129
Subtype期刊文献
AbstractThe photochemistry of two structure-related fluoroquinolones (FQs), antofloxacin (ANT) and levofloxacin (LEV), was studied in aqueous solution using stable and transient methods. The properties for energy transfer and electron transfer of these two FQs were also studied. The transient absorption spectra of FQs were observed, and transient species were assigned. The LEV triplet state ((LEV)-L-3*) spectra (lambda(max) = 610 nm) were determined, whereas the transient absorption of ANT could not be observed. The decay rate constant of (LEV)-L-3* via unimolecular attenuation, self-quenching, and quenching by oxygen was 32 x 10(5) s(-1), 6.72 x 10(8) M-1 s(-1), and 1.01 x 10(9) M-1 s(-1), respectively. A reasonable diagram showing the decay of (1)FQs* consisting of various substituents at the C-5 position was proposed. The phototoxicity of LEV and ANT was investigated and compared. Insertion of an amino group at the C-5 position made ANT relatively photostable and non-phototoxic compared with LEV. (C) 2015 Elsevier B.V. All rights reserved.
KeywordNeutral Aqueous-solution Fluoroquinolone Antibiotics Mycobacterium-tuberculosis Streptococcus-pneumoniae Quinolone Antibacterials Spectroscopic Properties Photophysical Properties Drug Lomefloxacin Electron-transfer Steady-state
DOI10.1016/j.jphotobiol.2015.12.004
Indexed BySCI
Language英语
WOS IDWOS:000370090700017
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/25693
Collection中科院上海应用物理研究所2011-2018年
Corresponding AuthorWang, WF (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China.; Lin, ZS (reprint author), Chinese Acad Sci, Tech Inst Phys & Chem, Ctr Crystal R&D, Key Lab Funct Crystals & Laser Technol, Beijing 100190, Peoples R China.
Recommended Citation
GB/T 7714
Zhao, JF,Liu, YC,Jiang, XX,et al. Effect of C-5 position on the photochemical properties and phototoxicity of antofloxacin and levofloxacin: A stable and transient study[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,2016,155(-):122—129.
APA Zhao, JF.,Liu, YC.,Jiang, XX.,Guo, P.,Xu, YL.,...&Lin, ZS .(2016).Effect of C-5 position on the photochemical properties and phototoxicity of antofloxacin and levofloxacin: A stable and transient study.JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,155(-),122—129.
MLA Zhao, JF,et al."Effect of C-5 position on the photochemical properties and phototoxicity of antofloxacin and levofloxacin: A stable and transient study".JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 155.-(2016):122—129.
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