Effect of C-5 position on the photochemical properties and phototoxicity of antofloxacin and levofloxacin: A stable and transient study
Zhao, JF; Liu, YC; Jiang, XX; Guo, P; Xu, YL; Zhang, P; Ji, TY; Lin, ZS; Wang, WF; Wang, WF (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China.; Lin, ZS (reprint author), Chinese Acad Sci, Tech Inst Phys & Chem, Ctr Crystal R&D, Key Lab Funct Crystals & Laser Technol, Beijing 100190, Peoples R China.
2016
发表期刊JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
ISSN1011-1344
卷号155期号:-页码:122—129
文章类型期刊文献
摘要The photochemistry of two structure-related fluoroquinolones (FQs), antofloxacin (ANT) and levofloxacin (LEV), was studied in aqueous solution using stable and transient methods. The properties for energy transfer and electron transfer of these two FQs were also studied. The transient absorption spectra of FQs were observed, and transient species were assigned. The LEV triplet state ((LEV)-L-3*) spectra (lambda(max) = 610 nm) were determined, whereas the transient absorption of ANT could not be observed. The decay rate constant of (LEV)-L-3* via unimolecular attenuation, self-quenching, and quenching by oxygen was 32 x 10(5) s(-1), 6.72 x 10(8) M-1 s(-1), and 1.01 x 10(9) M-1 s(-1), respectively. A reasonable diagram showing the decay of (1)FQs* consisting of various substituents at the C-5 position was proposed. The phototoxicity of LEV and ANT was investigated and compared. Insertion of an amino group at the C-5 position made ANT relatively photostable and non-phototoxic compared with LEV. (C) 2015 Elsevier B.V. All rights reserved.
关键词Neutral Aqueous-solution Fluoroquinolone Antibiotics Mycobacterium-tuberculosis Streptococcus-pneumoniae Quinolone Antibacterials Spectroscopic Properties Photophysical Properties Drug Lomefloxacin Electron-transfer Steady-state
DOI10.1016/j.jphotobiol.2015.12.004
收录类别SCI
语种英语
WOS记录号WOS:000370090700017
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/25693
专题中科院上海应用物理研究所2011-2018年
通讯作者Wang, WF (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China.; Lin, ZS (reprint author), Chinese Acad Sci, Tech Inst Phys & Chem, Ctr Crystal R&D, Key Lab Funct Crystals & Laser Technol, Beijing 100190, Peoples R China.
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Zhao, JF,Liu, YC,Jiang, XX,et al. Effect of C-5 position on the photochemical properties and phototoxicity of antofloxacin and levofloxacin: A stable and transient study[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,2016,155(-):122—129.
APA Zhao, JF.,Liu, YC.,Jiang, XX.,Guo, P.,Xu, YL.,...&Lin, ZS .(2016).Effect of C-5 position on the photochemical properties and phototoxicity of antofloxacin and levofloxacin: A stable and transient study.JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,155(-),122—129.
MLA Zhao, JF,et al."Effect of C-5 position on the photochemical properties and phototoxicity of antofloxacin and levofloxacin: A stable and transient study".JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 155.-(2016):122—129.
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