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| Enantioseparation of (RS)-ibuprofen by closed recycling high-speed counter-current chromatography using hydroxypropyl-beta-cyclodextrin as chiral selector | |
| Rong, LY; Liu, Q; Wang, J; Zeng, HL; Yang, H; Chen, XQ; Chen, XQ (reprint author), Cent S Univ, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China. | |
| 2016 | |
| 发表期刊 | TETRAHEDRON-ASYMMETRY
 |
| ISSN | 0957-4166 |
| 卷号 | 27期号:42559页码:301—306 |
| 文章类型 | 期刊文献 |
| 摘要 | High-speed counter-current chromatography combined with closed recycling elution mode was developed to enantioseparate (RS)-ibuprofen by using hydroxypropyl-beta-cyclodextrin (HP-beta-CD) as the chiral selector. Key parameters for high-speed counter-current chromatography resolution including the concentration of HP-beta-CD, the two-phase solvent system composition, equilibrium temperature, and the pH of aqueous phase were extensively investigated. Under the optimized conditions, the enantiomers of ibuprofen were successfully separated by preparative recycling high-speed counter-current chromatography and the resulting enantiopurity of each enantiomer was over 97.5% as determined by HPLC. Moreover, the recovery for (R,S)-ibuprofen from high-speed counter-current chromatography fractions was achieved in the range of 82-89%. (C) 2016 Elsevier Ltd. All rights reserved. |
| 关键词 | Performance Liquid-chromatography Enantiomeric Separation Mass-spectrometry Ibuprofen Extraction Resolution Plasma Drugs Acid |
| DOI | 10.1016/j.tetasy.2016.03.001 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000374709600001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.sinap.ac.cn/handle/331007/25710 |
| 专题 | 中科院上海应用物理研究所2011-2018年 |
| 通讯作者 | Chen, XQ (reprint author), Cent S Univ, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Rong, LY,Liu, Q,Wang, J,et al. Enantioseparation of (RS)-ibuprofen by closed recycling high-speed counter-current chromatography using hydroxypropyl-beta-cyclodextrin as chiral selector[J]. TETRAHEDRON-ASYMMETRY,2016,27(42559):301—306. |
| APA | Rong, LY.,Liu, Q.,Wang, J.,Zeng, HL.,Yang, H.,...&Chen, XQ .(2016).Enantioseparation of (RS)-ibuprofen by closed recycling high-speed counter-current chromatography using hydroxypropyl-beta-cyclodextrin as chiral selector.TETRAHEDRON-ASYMMETRY,27(42559),301—306. |
| MLA | Rong, LY,et al."Enantioseparation of (RS)-ibuprofen by closed recycling high-speed counter-current chromatography using hydroxypropyl-beta-cyclodextrin as chiral selector".TETRAHEDRON-ASYMMETRY 27.42559(2016):301—306. |
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