中国科学院上海应用物理研究所机构知识库
Advanced  
CAS OpenIR  > 中科院上海应用物理研究所2011-2017年  > 期刊论文
题名:
Enantioseparation of (RS)-ibuprofen by closed recycling high-speed counter-current chromatography using hydroxypropyl-beta-cyclodextrin as chiral selector
作者: Rong, LY; Liu, Q; Wang, J; Zeng, HL; Yang, H; Chen, XQ
刊名: TETRAHEDRON-ASYMMETRY
出版日期: 2016
卷号: 27, 期号:42559, 页码:301—306
关键词: PERFORMANCE LIQUID-CHROMATOGRAPHY ; ENANTIOMERIC SEPARATION ; MASS-SPECTROMETRY ; IBUPROFEN ; EXTRACTION ; RESOLUTION ; PLASMA ; DRUGS ; ACID
DOI: 10.1016/j.tetasy.2016.03.001
通讯作者: Chen, XQ (reprint author), Cent S Univ, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China.
文章类型: 期刊文献
英文摘要: High-speed counter-current chromatography combined with closed recycling elution mode was developed to enantioseparate (RS)-ibuprofen by using hydroxypropyl-beta-cyclodextrin (HP-beta-CD) as the chiral selector. Key parameters for high-speed counter-current chromatography resolution including the concentration of HP-beta-CD, the two-phase solvent system composition, equilibrium temperature, and the pH of aqueous phase were extensively investigated. Under the optimized conditions, the enantiomers of ibuprofen were successfully separated by preparative recycling high-speed counter-current chromatography and the resulting enantiopurity of each enantiomer was over 97.5% as determined by HPLC. Moreover, the recovery for (R,S)-ibuprofen from high-speed counter-current chromatography fractions was achieved in the range of 82-89%. (C) 2016 Elsevier Ltd. All rights reserved.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000374709600001
ISSN号: 0957-4166
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/25710
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Enantioseparation of (RS)-ibuprofen by closed recycling high-speed counter-current chromatography using hydroxypropyl-beta-cyclodextrin as chiral selector.pdf(955KB)期刊论文作者接受稿开放获取View Download

Recommended Citation:
Rong, LY,Liu, Q,Wang, J,et al. Enantioseparation of (RS)-ibuprofen by closed recycling high-speed counter-current chromatography using hydroxypropyl-beta-cyclodextrin as chiral selector[J]. TETRAHEDRON-ASYMMETRY,2016-01-01,27(42559):301—306.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Rong, LY]'s Articles
[Liu, Q]'s Articles
[Wang, J]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Rong, LY]‘s Articles
[Liu, Q]‘s Articles
[Wang, J]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Enantioseparation of (RS)-ibuprofen by closed recycling high-speed counter-current chromatography using hydroxypropyl-beta-cyclodextrin as chiral selector.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace