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Enantioseparation of (RS)-ibuprofen by closed recycling high-speed counter-current chromatography using hydroxypropyl-beta-cyclodextrin as chiral selector
Rong, LY; Liu, Q; Wang, J; Zeng, HL; Yang, H; Chen, XQ; Chen, XQ (reprint author), Cent S Univ, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China.
2016
Source PublicationTETRAHEDRON-ASYMMETRY
ISSN0957-4166
Volume27Issue:42559Pages:301—306
Subtype期刊文献
AbstractHigh-speed counter-current chromatography combined with closed recycling elution mode was developed to enantioseparate (RS)-ibuprofen by using hydroxypropyl-beta-cyclodextrin (HP-beta-CD) as the chiral selector. Key parameters for high-speed counter-current chromatography resolution including the concentration of HP-beta-CD, the two-phase solvent system composition, equilibrium temperature, and the pH of aqueous phase were extensively investigated. Under the optimized conditions, the enantiomers of ibuprofen were successfully separated by preparative recycling high-speed counter-current chromatography and the resulting enantiopurity of each enantiomer was over 97.5% as determined by HPLC. Moreover, the recovery for (R,S)-ibuprofen from high-speed counter-current chromatography fractions was achieved in the range of 82-89%. (C) 2016 Elsevier Ltd. All rights reserved.
KeywordPerformance Liquid-chromatography Enantiomeric Separation Mass-spectrometry Ibuprofen Extraction Resolution Plasma Drugs Acid
DOI10.1016/j.tetasy.2016.03.001
Indexed BySCI
Language英语
WOS IDWOS:000374709600001
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/25710
Collection中科院上海应用物理研究所2011-2019年
Corresponding AuthorChen, XQ (reprint author), Cent S Univ, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China.
Recommended Citation
GB/T 7714
Rong, LY,Liu, Q,Wang, J,et al. Enantioseparation of (RS)-ibuprofen by closed recycling high-speed counter-current chromatography using hydroxypropyl-beta-cyclodextrin as chiral selector[J]. TETRAHEDRON-ASYMMETRY,2016,27(42559):301—306.
APA Rong, LY.,Liu, Q.,Wang, J.,Zeng, HL.,Yang, H.,...&Chen, XQ .(2016).Enantioseparation of (RS)-ibuprofen by closed recycling high-speed counter-current chromatography using hydroxypropyl-beta-cyclodextrin as chiral selector.TETRAHEDRON-ASYMMETRY,27(42559),301—306.
MLA Rong, LY,et al."Enantioseparation of (RS)-ibuprofen by closed recycling high-speed counter-current chromatography using hydroxypropyl-beta-cyclodextrin as chiral selector".TETRAHEDRON-ASYMMETRY 27.42559(2016):301—306.
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