Enantioseparation of (RS)-ibuprofen by closed recycling high-speed counter-current chromatography using hydroxypropyl-beta-cyclodextrin as chiral selector
Chen, XQ (reprint author), Cent S Univ, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China.
文章类型:
期刊文献
英文摘要:
High-speed counter-current chromatography combined with closed recycling elution mode was developed to enantioseparate (RS)-ibuprofen by using hydroxypropyl-beta-cyclodextrin (HP-beta-CD) as the chiral selector. Key parameters for high-speed counter-current chromatography resolution including the concentration of HP-beta-CD, the two-phase solvent system composition, equilibrium temperature, and the pH of aqueous phase were extensively investigated. Under the optimized conditions, the enantiomers of ibuprofen were successfully separated by preparative recycling high-speed counter-current chromatography and the resulting enantiopurity of each enantiomer was over 97.5% as determined by HPLC. Moreover, the recovery for (R,S)-ibuprofen from high-speed counter-current chromatography fractions was achieved in the range of 82-89%. (C) 2016 Elsevier Ltd. All rights reserved.
Enantioseparation of (RS)-ibuprofen by closed recycling high-speed counter-current chromatography using hydroxypropyl-beta-cyclodextrin as chiral selector.pdf（955KB）
Rong, LY,Liu, Q,Wang, J,et al. Enantioseparation of (RS)-ibuprofen by closed recycling high-speed counter-current chromatography using hydroxypropyl-beta-cyclodextrin as chiral selector[J]. TETRAHEDRON-ASYMMETRY,2016-01-01,27(42559):301—306.
Enantioseparation of (RS)-ibuprofen by closed recycling high-speed counter-current chromatography using hydroxypropyl-beta-cyclodextrin as chiral selector.pdf
