Gd-based upconversion nanocarriers with yolk-shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer

doi:10.1039/c5nr06522d

CAS OpenIR > 中科院上海应用物理研究所2011-2018年

	Gd-based upconversion nanocarriers with yolk-shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer
	Pan, YW; Zhang, L; Zeng, LY; Ren, WZ; Xiao, XS; Zhang, JC; Zhang, LL; Li, AG; Lu, GM; Wu, AG; Zeng, LY (reprint author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Key Lab Magnet Mat & Devices, Ningbo 315201, Peoples R China.
	2016
发表期刊	NANOSCALE
ISSN	2040-3364
卷号	8 期号:2 页码:878—888
文章类型	期刊文献
摘要	Multidrug resistance (MDR) of cancers is still a major challenge, and it is very important to develop visualized nanoprobes for the diagnosis and treatment of drug resistant cancers. In this work, we developed a multifunctional delivery system based on DOX-encapsulated NaYF4:Yb/Er@NaGdF4 yolk-shell nanostructures for simultaneous dual-modal imaging and enhanced chemotherapy in drug resistant breast cancer. Using the large pore volume of the nanostructure, the delivery system had a high loading efficiency and excellent stability. Also, an in vitro and in vivo toxicity study showed the good biocompatibility of the as-prepared yolk-shell nanomaterials. Moreover, by nanocarrier delivery, the uptake of DOX could be greatly increased in drug resistant MCF-7/ADR cells. Compared with free DOX, the as-prepared delivery system enhanced the chemotherapy efficacy against MCF-7/ADR cells, indicating the excellent capability for overcoming MDR. Furthermore, core-shell NaYF4:Yb/Er@NaGdF4 improved the upconversion luminescence (UCL) performance, and the designed delivery system could also be applied for simultaneous UCL and magnetic resonance (MR) imaging, which could be a good candidate as a dual-modal imaging nanoprobe. Therefore, we developed a multifunctional yolk-shell delivery system, which could have potential applications as a visualized theranostic nanoprobe to overcome MDR in breast cancer.
关键词	Mesoporous Silica Nanoparticles In-vivo Photodynamic Therapy Magnetic-resonance Drug-delivery Tio2 Nanocarriers Doxorubicin Luminescent Nanocomposites Cells
DOI	10.1039/c5nr06522d
收录类别	SCI
语种	英语
WOS记录号	WOS:000367258500023
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.sinap.ac.cn/handle/331007/25732
专题	中科院上海应用物理研究所2011-2018年
通讯作者	Zeng, LY (reprint author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Key Lab Magnet Mat & Devices, Ningbo 315201, Peoples R China.
推荐引用方式 GB/T 7714	Pan, YW,Zhang, L,Zeng, LY,et al. Gd-based upconversion nanocarriers with yolk-shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer[J]. NANOSCALE,2016,8(2):878—888.
APA	Pan, YW.,Zhang, L.,Zeng, LY.,Ren, WZ.,Xiao, XS.,...&Zeng, LY .(2016).Gd-based upconversion nanocarriers with yolk-shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer.NANOSCALE,8(2),878—888.
MLA	Pan, YW,et al."Gd-based upconversion nanocarriers with yolk-shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer".NANOSCALE 8.2(2016):878—888.

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