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CAS OpenIR  > 中科院上海应用物理研究所2011-2017年  > 期刊论文
题名:
Gd-based upconversion nanocarriers with yolk-shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer
作者: Pan, YW; Zhang, L; Zeng, LY; Ren, WZ; Xiao, XS; Zhang, JC; Zhang, LL; Li, AG; Lu, GM; Wu, AG
刊名: NANOSCALE
出版日期: 2016
卷号: 8, 期号:2, 页码:878—888
关键词: MESOPOROUS SILICA NANOPARTICLES ; IN-VIVO ; PHOTODYNAMIC THERAPY ; MAGNETIC-RESONANCE ; DRUG-DELIVERY ; TIO2 NANOCARRIERS ; DOXORUBICIN ; LUMINESCENT ; NANOCOMPOSITES ; CELLS
DOI: 10.1039/c5nr06522d
通讯作者: Zeng, LY (reprint author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Key Lab Magnet Mat & Devices, Ningbo 315201, Peoples R China.
文章类型: 期刊文献
英文摘要: Multidrug resistance (MDR) of cancers is still a major challenge, and it is very important to develop visualized nanoprobes for the diagnosis and treatment of drug resistant cancers. In this work, we developed a multifunctional delivery system based on DOX-encapsulated NaYF4:Yb/Er@NaGdF4 yolk-shell nanostructures for simultaneous dual-modal imaging and enhanced chemotherapy in drug resistant breast cancer. Using the large pore volume of the nanostructure, the delivery system had a high loading efficiency and excellent stability. Also, an in vitro and in vivo toxicity study showed the good biocompatibility of the as-prepared yolk-shell nanomaterials. Moreover, by nanocarrier delivery, the uptake of DOX could be greatly increased in drug resistant MCF-7/ADR cells. Compared with free DOX, the as-prepared delivery system enhanced the chemotherapy efficacy against MCF-7/ADR cells, indicating the excellent capability for overcoming MDR. Furthermore, core-shell NaYF4:Yb/Er@NaGdF4 improved the upconversion luminescence (UCL) performance, and the designed delivery system could also be applied for simultaneous UCL and magnetic resonance (MR) imaging, which could be a good candidate as a dual-modal imaging nanoprobe. Therefore, we developed a multifunctional yolk-shell delivery system, which could have potential applications as a visualized theranostic nanoprobe to overcome MDR in breast cancer.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000367258500023
ISSN号: 2040-3364
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/25732
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

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Recommended Citation:
Pan, YW,Zhang, L,Zeng, LY,et al. Gd-based upconversion nanocarriers with yolk-shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer[J]. NANOSCALE,2016-01-01,8(2):878—888.
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