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Gd-based upconversion nanocarriers with yolk-shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer
Pan, YW; Zhang, L; Zeng, LY; Ren, WZ; Xiao, XS; Zhang, JC; Zhang, LL; Li, AG; Lu, GM; Wu, AG; Zeng, LY (reprint author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Key Lab Magnet Mat & Devices, Ningbo 315201, Peoples R China.
2016
Source PublicationNANOSCALE
ISSN2040-3364
Volume8Issue:2Pages:878—888
Subtype期刊文献
AbstractMultidrug resistance (MDR) of cancers is still a major challenge, and it is very important to develop visualized nanoprobes for the diagnosis and treatment of drug resistant cancers. In this work, we developed a multifunctional delivery system based on DOX-encapsulated NaYF4:Yb/Er@NaGdF4 yolk-shell nanostructures for simultaneous dual-modal imaging and enhanced chemotherapy in drug resistant breast cancer. Using the large pore volume of the nanostructure, the delivery system had a high loading efficiency and excellent stability. Also, an in vitro and in vivo toxicity study showed the good biocompatibility of the as-prepared yolk-shell nanomaterials. Moreover, by nanocarrier delivery, the uptake of DOX could be greatly increased in drug resistant MCF-7/ADR cells. Compared with free DOX, the as-prepared delivery system enhanced the chemotherapy efficacy against MCF-7/ADR cells, indicating the excellent capability for overcoming MDR. Furthermore, core-shell NaYF4:Yb/Er@NaGdF4 improved the upconversion luminescence (UCL) performance, and the designed delivery system could also be applied for simultaneous UCL and magnetic resonance (MR) imaging, which could be a good candidate as a dual-modal imaging nanoprobe. Therefore, we developed a multifunctional yolk-shell delivery system, which could have potential applications as a visualized theranostic nanoprobe to overcome MDR in breast cancer.
KeywordMesoporous Silica Nanoparticles In-vivo Photodynamic Therapy Magnetic-resonance Drug-delivery Tio2 Nanocarriers Doxorubicin Luminescent Nanocomposites Cells
DOI10.1039/c5nr06522d
Indexed BySCI
Language英语
WOS IDWOS:000367258500023
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/25732
Collection中科院上海应用物理研究所2011-2018年
Corresponding AuthorZeng, LY (reprint author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Key Lab Magnet Mat & Devices, Ningbo 315201, Peoples R China.
Recommended Citation
GB/T 7714
Pan, YW,Zhang, L,Zeng, LY,et al. Gd-based upconversion nanocarriers with yolk-shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer[J]. NANOSCALE,2016,8(2):878—888.
APA Pan, YW.,Zhang, L.,Zeng, LY.,Ren, WZ.,Xiao, XS.,...&Zeng, LY .(2016).Gd-based upconversion nanocarriers with yolk-shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer.NANOSCALE,8(2),878—888.
MLA Pan, YW,et al."Gd-based upconversion nanocarriers with yolk-shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer".NANOSCALE 8.2(2016):878—888.
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