Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
Gd-based upconversion nanocarriers with yolk-shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer | |
Pan, YW; Zhang, L; Zeng, LY; Ren, WZ; Xiao, XS; Zhang, JC; Zhang, LL; Li, AG; Lu, GM; Wu, AG; Zeng, LY (reprint author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Key Lab Magnet Mat & Devices, Ningbo 315201, Peoples R China. | |
2016 | |
Source Publication | NANOSCALE
![]() |
ISSN | 2040-3364 |
Volume | 8Issue:2Pages:878—888 |
Subtype | 期刊文献 |
Abstract | Multidrug resistance (MDR) of cancers is still a major challenge, and it is very important to develop visualized nanoprobes for the diagnosis and treatment of drug resistant cancers. In this work, we developed a multifunctional delivery system based on DOX-encapsulated NaYF4:Yb/Er@NaGdF4 yolk-shell nanostructures for simultaneous dual-modal imaging and enhanced chemotherapy in drug resistant breast cancer. Using the large pore volume of the nanostructure, the delivery system had a high loading efficiency and excellent stability. Also, an in vitro and in vivo toxicity study showed the good biocompatibility of the as-prepared yolk-shell nanomaterials. Moreover, by nanocarrier delivery, the uptake of DOX could be greatly increased in drug resistant MCF-7/ADR cells. Compared with free DOX, the as-prepared delivery system enhanced the chemotherapy efficacy against MCF-7/ADR cells, indicating the excellent capability for overcoming MDR. Furthermore, core-shell NaYF4:Yb/Er@NaGdF4 improved the upconversion luminescence (UCL) performance, and the designed delivery system could also be applied for simultaneous UCL and magnetic resonance (MR) imaging, which could be a good candidate as a dual-modal imaging nanoprobe. Therefore, we developed a multifunctional yolk-shell delivery system, which could have potential applications as a visualized theranostic nanoprobe to overcome MDR in breast cancer. |
Keyword | Mesoporous Silica Nanoparticles In-vivo Photodynamic Therapy Magnetic-resonance Drug-delivery Tio2 Nanocarriers Doxorubicin Luminescent Nanocomposites Cells |
DOI | 10.1039/c5nr06522d |
Indexed By | SCI |
Language | 英语 |
WOS ID | WOS:000367258500023 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.sinap.ac.cn/handle/331007/25732 |
Collection | 中科院上海应用物理研究所2011-2020年 |
Corresponding Author | Zeng, LY (reprint author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Key Lab Magnet Mat & Devices, Ningbo 315201, Peoples R China. |
Recommended Citation GB/T 7714 | Pan, YW,Zhang, L,Zeng, LY,et al. Gd-based upconversion nanocarriers with yolk-shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer[J]. NANOSCALE,2016,8(2):878—888. |
APA | Pan, YW.,Zhang, L.,Zeng, LY.,Ren, WZ.,Xiao, XS.,...&Zeng, LY .(2016).Gd-based upconversion nanocarriers with yolk-shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer.NANOSCALE,8(2),878—888. |
MLA | Pan, YW,et al."Gd-based upconversion nanocarriers with yolk-shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer".NANOSCALE 8.2(2016):878—888. |
Files in This Item: | Download All | |||||
File Name/Size | DocType | Version | Access | License | ||
Gd-based upconversio(4087KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment