Highly narrow nanogap-containing Au@Au core-shell SERS nanoparticles: size-dependent Raman enhancement and applications in cancer cell imaging
Hu, CY; Shen, JL; Yan, J; Zhong, J; Qin, WW; Liu, R; Aldalbahi, A; Zuo, XL; Song, SP; Fan, CH; He, DN; He, DN (reprint author), Shanghai Jiao Tong Univ, Sch Mat Sci & Engn, Shanghai 200240, Peoples R China.; Yan, J (reprint author), Natl Engn Res Ctr Nanotechnol, Shanghai 200241, Peoples R China.
2016
发表期刊NANOSCALE
ISSN2040-3364
卷号8期号:4页码:2090—2096
文章类型期刊文献
摘要Cellular imaging technologies employing metallic surface-enhanced Raman scattering (SERS) tags have gained much interest toward clinical diagnostics, but they are still suffering from poor controlled distribution of hot spots and reproducibility of SERS signals. Here, we report the fabrication and characterization of high narrow nanogap-containing Au@Au core-shell SERS nanoparticles (GCNPs) for the identification and imaging of proteins overexpressed on the surface of cancer cells. First, plasmonic nanostructures are made of gold nanoparticles (similar to 15 nm) coated with gold shells, between which a highly narrow and uniform nanogap (similar to 1.1 nm) is formed owing to polyA anchored on the Au cores. The well controlled distribution of Raman reporter molecules, such as 4,4'-dipyridyl (44DP) and 5,5'-dithiobis(2-nitrobenzoic acid) (DTNB), are readily encoded in the nanogap and can generate strong, reproducible SERS signals. In addition, we have investigated the size-dependent SERS activity of GCNPs and found that with the same laser wavelength, the Raman enhancement discriminated between particle sizes. The maximum Raman enhancement was achieved at a certain threshold of particle size (similar to 76 nm). High narrow nanogap-containing Au@Au core-shell SERS tags (GCTs) were prepared via the functionalization of hyaluronic acid (HA) on GCNPs, which recognized the CD44 receptor, a tumor-associated surface biomarker. And it was shown that GCTs have a good targeting ability to tumour cells and promising prospects for multiplex biomarker detection.
关键词Single-molecule Sers Hot-spots Gold Nanoparticles Live Cells Scattering Spectroscopy Tags Dna Cytotoxicity Localization
DOI10.1039/c5nr06919j
收录类别SCI
语种英语
WOS记录号WOS:000368860900039
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/25743
专题中科院上海应用物理研究所2011-2018年
通讯作者He, DN (reprint author), Shanghai Jiao Tong Univ, Sch Mat Sci & Engn, Shanghai 200240, Peoples R China.; Yan, J (reprint author), Natl Engn Res Ctr Nanotechnol, Shanghai 200241, Peoples R China.
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Hu, CY,Shen, JL,Yan, J,et al. Highly narrow nanogap-containing Au@Au core-shell SERS nanoparticles: size-dependent Raman enhancement and applications in cancer cell imaging[J]. NANOSCALE,2016,8(4):2090—2096.
APA Hu, CY.,Shen, JL.,Yan, J.,Zhong, J.,Qin, WW.,...&Yan, J .(2016).Highly narrow nanogap-containing Au@Au core-shell SERS nanoparticles: size-dependent Raman enhancement and applications in cancer cell imaging.NANOSCALE,8(4),2090—2096.
MLA Hu, CY,et al."Highly narrow nanogap-containing Au@Au core-shell SERS nanoparticles: size-dependent Raman enhancement and applications in cancer cell imaging".NANOSCALE 8.4(2016):2090—2096.
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