CAS OpenIR  > 中科院上海应用物理研究所2011-2018年
Highly narrow nanogap-containing Au@Au core-shell SERS nanoparticles: size-dependent Raman enhancement and applications in cancer cell imaging
Hu, CY; Shen, JL; Yan, J; Zhong, J; Qin, WW; Liu, R; Aldalbahi, A; Zuo, XL; Song, SP; Fan, CH; He, DN; He, DN (reprint author), Shanghai Jiao Tong Univ, Sch Mat Sci & Engn, Shanghai 200240, Peoples R China.; Yan, J (reprint author), Natl Engn Res Ctr Nanotechnol, Shanghai 200241, Peoples R China.
2016
Source PublicationNANOSCALE
ISSN2040-3364
Volume8Issue:4Pages:2090—2096
Subtype期刊文献
AbstractCellular imaging technologies employing metallic surface-enhanced Raman scattering (SERS) tags have gained much interest toward clinical diagnostics, but they are still suffering from poor controlled distribution of hot spots and reproducibility of SERS signals. Here, we report the fabrication and characterization of high narrow nanogap-containing Au@Au core-shell SERS nanoparticles (GCNPs) for the identification and imaging of proteins overexpressed on the surface of cancer cells. First, plasmonic nanostructures are made of gold nanoparticles (similar to 15 nm) coated with gold shells, between which a highly narrow and uniform nanogap (similar to 1.1 nm) is formed owing to polyA anchored on the Au cores. The well controlled distribution of Raman reporter molecules, such as 4,4'-dipyridyl (44DP) and 5,5'-dithiobis(2-nitrobenzoic acid) (DTNB), are readily encoded in the nanogap and can generate strong, reproducible SERS signals. In addition, we have investigated the size-dependent SERS activity of GCNPs and found that with the same laser wavelength, the Raman enhancement discriminated between particle sizes. The maximum Raman enhancement was achieved at a certain threshold of particle size (similar to 76 nm). High narrow nanogap-containing Au@Au core-shell SERS tags (GCTs) were prepared via the functionalization of hyaluronic acid (HA) on GCNPs, which recognized the CD44 receptor, a tumor-associated surface biomarker. And it was shown that GCTs have a good targeting ability to tumour cells and promising prospects for multiplex biomarker detection.
KeywordSingle-molecule Sers Hot-spots Gold Nanoparticles Live Cells Scattering Spectroscopy Tags Dna Cytotoxicity Localization
DOI10.1039/c5nr06919j
Indexed BySCI
Language英语
WOS IDWOS:000368860900039
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/25743
Collection中科院上海应用物理研究所2011-2018年
Corresponding AuthorHe, DN (reprint author), Shanghai Jiao Tong Univ, Sch Mat Sci & Engn, Shanghai 200240, Peoples R China.; Yan, J (reprint author), Natl Engn Res Ctr Nanotechnol, Shanghai 200241, Peoples R China.
Recommended Citation
GB/T 7714
Hu, CY,Shen, JL,Yan, J,et al. Highly narrow nanogap-containing Au@Au core-shell SERS nanoparticles: size-dependent Raman enhancement and applications in cancer cell imaging[J]. NANOSCALE,2016,8(4):2090—2096.
APA Hu, CY.,Shen, JL.,Yan, J.,Zhong, J.,Qin, WW.,...&Yan, J .(2016).Highly narrow nanogap-containing Au@Au core-shell SERS nanoparticles: size-dependent Raman enhancement and applications in cancer cell imaging.NANOSCALE,8(4),2090—2096.
MLA Hu, CY,et al."Highly narrow nanogap-containing Au@Au core-shell SERS nanoparticles: size-dependent Raman enhancement and applications in cancer cell imaging".NANOSCALE 8.4(2016):2090—2096.
Files in This Item: Download All
File Name/Size DocType Version Access License
Highly narrow nanoga(3636KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Hu, CY]'s Articles
[Shen, JL]'s Articles
[Yan, J]'s Articles
Baidu academic
Similar articles in Baidu academic
[Hu, CY]'s Articles
[Shen, JL]'s Articles
[Yan, J]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Hu, CY]'s Articles
[Shen, JL]'s Articles
[Yan, J]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Highly narrow nanogap-containing Au@Au core-shell SERS nanoparticles_ size-dependent Raman enhancement and applications in cancer cell imaging.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.