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CAS OpenIR  > 中科院上海应用物理研究所2011-2017年  > 期刊论文
题名:
Highly narrow nanogap-containing Au@Au core-shell SERS nanoparticles: size-dependent Raman enhancement and applications in cancer cell imaging
作者: Hu, CY; Shen, JL; Yan, J; Zhong, J; Qin, WW; Liu, R; Aldalbahi, A; Zuo, XL; Song, SP; Fan, CH; He, DN
刊名: NANOSCALE
出版日期: 2016
卷号: 8, 期号:4, 页码:2090—2096
关键词: SINGLE-MOLECULE SERS ; HOT-SPOTS ; GOLD NANOPARTICLES ; LIVE CELLS ; SCATTERING ; SPECTROSCOPY ; TAGS ; DNA ; CYTOTOXICITY ; LOCALIZATION
DOI: 10.1039/c5nr06919j
通讯作者: He, DN (reprint author), Shanghai Jiao Tong Univ, Sch Mat Sci & Engn, Shanghai 200240, Peoples R China. ; Yan, J (reprint author), Natl Engn Res Ctr Nanotechnol, Shanghai 200241, Peoples R China.
文章类型: 期刊文献
英文摘要: Cellular imaging technologies employing metallic surface-enhanced Raman scattering (SERS) tags have gained much interest toward clinical diagnostics, but they are still suffering from poor controlled distribution of hot spots and reproducibility of SERS signals. Here, we report the fabrication and characterization of high narrow nanogap-containing Au@Au core-shell SERS nanoparticles (GCNPs) for the identification and imaging of proteins overexpressed on the surface of cancer cells. First, plasmonic nanostructures are made of gold nanoparticles (similar to 15 nm) coated with gold shells, between which a highly narrow and uniform nanogap (similar to 1.1 nm) is formed owing to polyA anchored on the Au cores. The well controlled distribution of Raman reporter molecules, such as 4,4'-dipyridyl (44DP) and 5,5'-dithiobis(2-nitrobenzoic acid) (DTNB), are readily encoded in the nanogap and can generate strong, reproducible SERS signals. In addition, we have investigated the size-dependent SERS activity of GCNPs and found that with the same laser wavelength, the Raman enhancement discriminated between particle sizes. The maximum Raman enhancement was achieved at a certain threshold of particle size (similar to 76 nm). High narrow nanogap-containing Au@Au core-shell SERS tags (GCTs) were prepared via the functionalization of hyaluronic acid (HA) on GCNPs, which recognized the CD44 receptor, a tumor-associated surface biomarker. And it was shown that GCTs have a good targeting ability to tumour cells and promising prospects for multiplex biomarker detection.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000368860900039
ISSN号: 2040-3364
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/25743
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

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Recommended Citation:
Hu, CY,Shen, JL,Yan, J,et al. Highly narrow nanogap-containing Au@Au core-shell SERS nanoparticles: size-dependent Raman enhancement and applications in cancer cell imaging[J]. NANOSCALE,2016-01-01,8(4):2090—2096.
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