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题名:
Mechanical force-induced polymerization and depolymerization of F-actin at water/solid interfaces
作者: Zhang, XQ; Hu, XY; Lei, HZ; Hu, J; Zhang, Y
刊名: NANOSCALE
出版日期: 2016
卷号: 8, 期号:11, 页码:6008—6013
关键词: FOCAL ADHESIONS ; MOTILITY DRIVEN ; CELL MOTILITY ; FILAMENTS ; MICROSCOPY ; CYTOSKELETON ; NANOFIBERS ; NUCLEATION ; INTEGRINS ; COMPLEXES
DOI: 10.1039/c5nr08713a
通讯作者: Zhang, Y (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China.
文章类型: 期刊文献
英文摘要: Actin molecules are among the three main cytoskeleton proteins of cells and undergo rapid cycling to regulate critical processes such as endocytosis, cytokinesis, cell polarity, and cell morphogenesis. Although extensive studies have been carried out on the dynamics as well as biological functions of actin polymerization and depolymerization both in vivo and in vitro, the molecular mechanisms by which cells sense and respond to mechanical signals are not fully understood. In particular, little attention has been paid to the effect of a physical force that is exerted directly on the actin cytoskeleton. In this paper, we have explored how the mechanical force affects the actin polymerization and depolymerization behaviors at water/solid interfaces using an atomic force microscope (AFM) operated in liquid. By raster scanning an AFM probe on a substrate surface with a certain load, it was found that actin monomers could polymerize into filaments without the help of actin related proteins (ARPs). Further study indicated that actin monomers were inclined to form filaments only under a small scanning load. The polymerized actin filaments would be depolymerized when the mechanical force was stronger. A possible mechanism has been suggested to explain the mechanical force induced actin polymerization.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000372245900026
ISSN号: 2040-3364
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/25770
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

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Recommended Citation:
Zhang, XQ,Hu, XY,Lei, HZ,et al. Mechanical force-induced polymerization and depolymerization of F-actin at water/solid interfaces[J]. NANOSCALE,2016-01-01,8(11):6008—6013.
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文件名: Mechanical force-induced polymerization and depolymerization of F-actin at watersolid interfaces.pdf
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