Multiple-Armed Tetrahedral DNA Nanostructures for Tumor-Targeting, Dual-Modality in Vivo Imaging
Jiang, DW; Sun, YH; Li, J; Li, Q; Lv, M; Zhu, B; Tian, T; Cheng, DF; Xia, JY; Zhang, L; Wang, LH; Huang, Q; Shi, JY; Fan, CH; Wang, LH (reprint author), Chinese Acad Sci, Div Phys Biol, Shanghai 201800, Peoples R China.; Wang, LH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr, Shanghai 201800, Peoples R China.
2016
发表期刊ACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
卷号8期号:7页码:4378—4384
文章类型期刊文献
摘要In this work, we have developed multiple-armed DNA tetrahedral nanostructures (TDNs) for dual-modality in vivo imaging using near-infrared (NIR) fluorescence and single-photon emission computed tomography (SPECT). We found that the presence of arm strands in TDNs remarkably enhanced their in vitro stability, allowing them to stay intact for at least 12 h in serum. By using NIR fluorescence imaging, we evaluated in mice the pharmacokinetics of TDNs, which exhibited distinctly different in vivo biodistribution patterns compared with those of double-stranded (ds)DNA. We also noticed that TDNs had twofold longer circulation time in the blood system than that of dsDNA. With the use of multiple armed TDNs, we could precisely anchor an exact number of functional groups including tumor-targeting folic acid (FA), NIR emitter Dylight 755, and radioactive isotope Tc-99m on prescribed positions of TDNs, which showed the capability of targeted imaging ability in cancer cells. Furthermore, we realized noninvasive tumor-targeting imaging in tumor-bearing mice by using both NIR and SPECT modalities.
关键词Quantum Dots Multifunctional Nanoparticles Inorganic Nanoparticles Carbon Nanotubes Cancer-therapy Delivery Stability Spect Pet Nanotechnology
DOI10.1021/acsami.5b10792
收录类别SCI
语种英语
WOS记录号WOS:000371105800015
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/25778
专题中科院上海应用物理研究所2011-2018年
通讯作者Sun, YH; Zhang, L; Wang, LH (reprint author), Chinese Acad Sci, Div Phys Biol, Shanghai 201800, Peoples R China.; Wang, LH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr, Shanghai 201800, Peoples R China.
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Jiang, DW,Sun, YH,Li, J,et al. Multiple-Armed Tetrahedral DNA Nanostructures for Tumor-Targeting, Dual-Modality in Vivo Imaging[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(7):4378—4384.
APA Jiang, DW.,Sun, YH.,Li, J.,Li, Q.,Lv, M.,...&Wang, LH .(2016).Multiple-Armed Tetrahedral DNA Nanostructures for Tumor-Targeting, Dual-Modality in Vivo Imaging.ACS APPLIED MATERIALS & INTERFACES,8(7),4378—4384.
MLA Jiang, DW,et al."Multiple-Armed Tetrahedral DNA Nanostructures for Tumor-Targeting, Dual-Modality in Vivo Imaging".ACS APPLIED MATERIALS & INTERFACES 8.7(2016):4378—4384.
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