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CAS OpenIR  > 中科院上海应用物理研究所2011-2017年  > 期刊论文
题名:
Multiple-Armed Tetrahedral DNA Nanostructures for Tumor-Targeting, Dual-Modality in Vivo Imaging
作者: Jiang, DW; Sun, YH; Li, J; Li, Q; Lv, M; Zhu, B; Tian, T; Cheng, DF; Xia, JY; Zhang, L; Wang, LH; Huang, Q; Shi, JY; Fan, CH
刊名: ACS APPLIED MATERIALS & INTERFACES
出版日期: 2016
卷号: 8, 期号:7, 页码:4378—4384
关键词: QUANTUM DOTS ; MULTIFUNCTIONAL NANOPARTICLES ; INORGANIC NANOPARTICLES ; CARBON NANOTUBES ; CANCER-THERAPY ; DELIVERY ; STABILITY ; SPECT ; PET ; NANOTECHNOLOGY
DOI: 10.1021/acsami.5b10792
通讯作者: Sun, YH ; Zhang, L ; Wang, LH (reprint author), Chinese Acad Sci, Div Phys Biol, Shanghai 201800, Peoples R China. ; Sun, YH ; Zhang, L ; Wang, LH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr, Shanghai 201800, Peoples R China.
文章类型: 期刊文献
英文摘要: In this work, we have developed multiple-armed DNA tetrahedral nanostructures (TDNs) for dual-modality in vivo imaging using near-infrared (NIR) fluorescence and single-photon emission computed tomography (SPECT). We found that the presence of arm strands in TDNs remarkably enhanced their in vitro stability, allowing them to stay intact for at least 12 h in serum. By using NIR fluorescence imaging, we evaluated in mice the pharmacokinetics of TDNs, which exhibited distinctly different in vivo biodistribution patterns compared with those of double-stranded (ds)DNA. We also noticed that TDNs had twofold longer circulation time in the blood system than that of dsDNA. With the use of multiple armed TDNs, we could precisely anchor an exact number of functional groups including tumor-targeting folic acid (FA), NIR emitter Dylight 755, and radioactive isotope Tc-99m on prescribed positions of TDNs, which showed the capability of targeted imaging ability in cancer cells. Furthermore, we realized noninvasive tumor-targeting imaging in tumor-bearing mice by using both NIR and SPECT modalities.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000371105800015
ISSN号: 1944-8244
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/25778
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

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Recommended Citation:
Jiang, DW,Sun, YH,Li, J,et al. Multiple-Armed Tetrahedral DNA Nanostructures for Tumor-Targeting, Dual-Modality in Vivo Imaging[J]. ACS APPLIED MATERIALS & INTERFACES,2016-01-01,8(7):4378—4384.
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