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Multiple-Armed Tetrahedral DNA Nanostructures for Tumor-Targeting, Dual-Modality in Vivo Imaging
Jiang, DW; Sun, YH; Li, J; Li, Q; Lv, M; Zhu, B; Tian, T; Cheng, DF; Xia, JY; Zhang, L; Wang, LH; Huang, Q; Shi, JY; Fan, CH; Wang, LH (reprint author), Chinese Acad Sci, Div Phys Biol, Shanghai 201800, Peoples R China.; Wang, LH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr, Shanghai 201800, Peoples R China.
2016
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume8Issue:7Pages:4378—4384
Subtype期刊文献
AbstractIn this work, we have developed multiple-armed DNA tetrahedral nanostructures (TDNs) for dual-modality in vivo imaging using near-infrared (NIR) fluorescence and single-photon emission computed tomography (SPECT). We found that the presence of arm strands in TDNs remarkably enhanced their in vitro stability, allowing them to stay intact for at least 12 h in serum. By using NIR fluorescence imaging, we evaluated in mice the pharmacokinetics of TDNs, which exhibited distinctly different in vivo biodistribution patterns compared with those of double-stranded (ds)DNA. We also noticed that TDNs had twofold longer circulation time in the blood system than that of dsDNA. With the use of multiple armed TDNs, we could precisely anchor an exact number of functional groups including tumor-targeting folic acid (FA), NIR emitter Dylight 755, and radioactive isotope Tc-99m on prescribed positions of TDNs, which showed the capability of targeted imaging ability in cancer cells. Furthermore, we realized noninvasive tumor-targeting imaging in tumor-bearing mice by using both NIR and SPECT modalities.
KeywordQuantum Dots Multifunctional Nanoparticles Inorganic Nanoparticles Carbon Nanotubes Cancer-therapy Delivery Stability Spect Pet Nanotechnology
DOI10.1021/acsami.5b10792
Indexed BySCI
Language英语
WOS IDWOS:000371105800015
Citation statistics
Cited Times:39[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/25778
Collection中科院上海应用物理研究所2011-2018年
Corresponding AuthorSun, YH; Zhang, L; Wang, LH (reprint author), Chinese Acad Sci, Div Phys Biol, Shanghai 201800, Peoples R China.; Wang, LH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr, Shanghai 201800, Peoples R China.
Recommended Citation
GB/T 7714
Jiang, DW,Sun, YH,Li, J,et al. Multiple-Armed Tetrahedral DNA Nanostructures for Tumor-Targeting, Dual-Modality in Vivo Imaging[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(7):4378—4384.
APA Jiang, DW.,Sun, YH.,Li, J.,Li, Q.,Lv, M.,...&Wang, LH .(2016).Multiple-Armed Tetrahedral DNA Nanostructures for Tumor-Targeting, Dual-Modality in Vivo Imaging.ACS APPLIED MATERIALS & INTERFACES,8(7),4378—4384.
MLA Jiang, DW,et al."Multiple-Armed Tetrahedral DNA Nanostructures for Tumor-Targeting, Dual-Modality in Vivo Imaging".ACS APPLIED MATERIALS & INTERFACES 8.7(2016):4378—4384.
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