CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Preparation and Biological Applications of DNA Hydrogel
Song, P; Ye, DK; Song, SP; Wang, LH; Zuo, XL; Zuo, XL (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China.
2016
Source PublicationPROGRESS IN CHEMISTRY
ISSN1005-281X
Volume28Issue:5Pages:628—636
Subtype期刊文献
AbstractDNA possesses characteristics such as excellent biocompatibility, biodegradation, molecular recognition ability, nanoscale controllability and programmability. In recent decades, DNA has taken on an assortment of diverse roles, not only as the central genetic molecule in biological systems but also as generic materials for nanoscale engineering. DNA hydrogel combines the characteristics both from DNA and hydrogel, such as controllable shape, high mechanical strength, materials delivery. The hydrogel formation includes chemical method based formation via covalent bond and physical method based formation via non covalent bond. DNA hydrogel can combine with perssad, molecule or DNA sequence which can be sensitive to incitant stimulating factor in order to expand the application of DNA hydrogel. DNA hydrogel can be sensitive to stimuli response, such as pH, light, temperature and small molecules. These novel DNA hydrogels provide a natural bridge between nanotechnology and biotechnology, and this also leads DNA hydrogel to far-ranging real-world applications. Because of this, DNA hydrogel as a smart material has been widely used in biosensor, drug delivery, and three-dimensional cell culture. In this review, we summarize the classification of DNA hydrogel and then give the stimuli-response DNA hydrogel and its biological application. Also, the development prospect of DNA hydrogel is demonstrated.
KeywordHybridization Chain-reaction Cross-linked Hydrogel Nucleic-acids Strand-displacement Single Cells Target Nanostructures Nanotechnology Transport Delivery
DOI10.7536/PC160141
Indexed BySCI
Language英语
WOS IDWOS:000377640400003
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/25807
Collection中科院上海应用物理研究所2011-2019年
Corresponding AuthorZuo, XL (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China.
Recommended Citation
GB/T 7714
Song, P,Ye, DK,Song, SP,et al. Preparation and Biological Applications of DNA Hydrogel[J]. PROGRESS IN CHEMISTRY,2016,28(5):628—636.
APA Song, P,Ye, DK,Song, SP,Wang, LH,Zuo, XL,&Zuo, XL .(2016).Preparation and Biological Applications of DNA Hydrogel.PROGRESS IN CHEMISTRY,28(5),628—636.
MLA Song, P,et al."Preparation and Biological Applications of DNA Hydrogel".PROGRESS IN CHEMISTRY 28.5(2016):628—636.
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