中国科学院上海应用物理研究所机构知识库
Advanced  
CAS OpenIR  > 中科院上海应用物理研究所2011-2017年  > 期刊论文
题名:
Robust Biopolymeric Supramolecular "Host-Guest Macromer" Hydrogels Reinforced by in Situ Formed Multivalent Nanoclusters for Cartilage Regeneration
作者: Wei, KC; Zhu, ML; Sun, YX; Xu, JB; Feng, Q; Lin, S; Wu, TY; Xu, J; Tian, F; Xia, J; Li, G; Bian, LM
刊名: MACROMOLECULES
出版日期: 2016
卷号: 49, 期号:3, 页码:866—875
关键词: HYALURONIC-ACID HYDROGELS ; MESENCHYMAL STEM-CELLS ; X-RAY-SCATTERING ; MECHANICAL-PROPERTIES ; 3-DIMENSIONAL HYDROGELS ; BETA-CYCLODEXTRIN ; BIOMATERIALS ; ASSEMBLIES ; CHONDROGENESIS ; COMPLEXATION
DOI: 10.1021/acs.macromol.5b02527
通讯作者: Bian, LM (reprint author), Prince Wales Hosp, Dept Mech & Automat Engn, Div Biomed Engn, Hong Kong, Hong Kong, Peoples R China. ; Bian, LM (reprint author), Prince Wales Hosp, Shun Hing Inst Adv Engn, Hong Kong, Hong Kong, Peoples R China. ; Bian, LM (reprint author), Chinese Univ Hong Kong, Shenzhen Res Inst, Shatin, Hong Kong, Peoples R China. ; Bian, LM (reprint author), China Orthoped Regenerat Med Grp CORMed, Shanghai, Peoples R China.
文章类型: 期刊文献
英文摘要: Biopolymer-based supramolecular hydrogels cross-linked by host guest interactions are usually mechanically weak as shown in "inverted vials" instead of freestanding 3D constructs. Herein, we describe a novel host guest macromer (HGM) approach for preparation of biopolymer-based freestanding supramolecular hydrogels. Host guest macromers are formed by molecular self-assembly between adamantane-functionalized hyaluronic acid (AD(x)HA) guest polymers and monoacrylated beta-cyclodextrins (mono-Ac-beta CD) host monomers. 'Supramolecular hydrogels are readily prepared by UV-induced polymerization of the preassembled host guest macromers. Such hydrogels are soely cross-linked by in situ formed multivalent host guest nanoclusters and show significantly reinforced mechanical properties yet still retain desirable supramolecular features. They can self-heal and be remolded into freestanding 3D constructs which afford effective protection on the encapsulated stem cells during the compression remolding, making them promising carriers for therapeutic cells that can quickly adapt to and integrate with surrounding tissues of the targeted defects. We demonstrate that such hydrogels not only sustain extended release of encapsulated proteinaceous growth factors (TGF-beta 1) but also support chondrogenesis of the human mesenchymal stem cells (hMSCs) and promote cartilage regeneration in a rat model.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000370113300016
ISSN号: 0024-9297
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/25826
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Robust Biopolymeric Supramolecular Host-Guest Macromer Hydrogels Reinforced by in Situ Formed Multivalent Nanoclusters for Cartilage Regeneration.pdf(7506KB)期刊论文作者接受稿开放获取View Download

Recommended Citation:
Wei, KC,Zhu, ML,Sun, YX,et al. Robust Biopolymeric Supramolecular "Host-Guest Macromer" Hydrogels Reinforced by in Situ Formed Multivalent Nanoclusters for Cartilage Regeneration[J]. MACROMOLECULES,2016-01-01,49(3):866—875.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wei, KC]'s Articles
[Zhu, ML]'s Articles
[Sun, YX]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wei, KC]‘s Articles
[Zhu, ML]‘s Articles
[Sun, YX]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Robust Biopolymeric Supramolecular Host-Guest Macromer Hydrogels Reinforced by in Situ Formed Multivalent Nanoclusters for Cartilage Regeneration.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace