Sodium alginate-functionalized nanodiamonds as sustained chemotherapeutic drug-release vectors
Cui, ZF; Zhang, Y; Zhang, JC; Kong, HT; Tang, XX; Pan, L; Xia, K; Aldalbahi, A; Li, AG; Tai, RZ; Fan, CH; Zhu, Y; Zhang, JC (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Div Phys Biol, Shanghai 201800, Peoples R China.
2016
发表期刊CARBON
ISSN0008-6223
卷号97期号:-页码:78—86
文章类型期刊文献
摘要Prolonged therapeutic action over an extended period of time on single dose is vital in designing an ideal drug delivery system. Nanoparticle-based vehicles for drug delivery serves as an ideal technology, however, utilization of them remains controversial due to potential safety concerns and transient drug retention. Nanodiamonds (NDs), with excellent biocompatibility and diversity of potential conjugates, have emerged as alternative promising materials in this regard. Here, we developed sodium alginate functionalized NDs (fNDs) for drug delivery. Cisplatin (DDP) was chosen as a model drug and coated on the negatively charged fNDs clusters. Our work demonstrated that fNDs were capable of enhancing drug accumulation and retention time in tumor cells, leading to continued tumor cell killing effect after clearance of drug treatment. Furthermore, fNDs-DDP treatment improved drug safety compared to DDP treatment. Thus, this new platform may have strong potential for further biomedical application. (C) 2015 Elsevier Ltd. All rights reserved.
关键词Antitumor-activity Carbon Nanotubes Cancer-therapy Delivery Cisplatin Nanocarrier Cells Biocompatibility Therapeutics Accumulation
DOI10.1016/j.carbon.2015.07.066
收录类别SCI
语种英语
WOS记录号WOS:000366939900008
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/25835
专题中科院上海应用物理研究所2011-2018年
通讯作者Zhang, JC (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Div Phys Biol, Shanghai 201800, Peoples R China.
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GB/T 7714
Cui, ZF,Zhang, Y,Zhang, JC,et al. Sodium alginate-functionalized nanodiamonds as sustained chemotherapeutic drug-release vectors[J]. CARBON,2016,97(-):78—86.
APA Cui, ZF.,Zhang, Y.,Zhang, JC.,Kong, HT.,Tang, XX.,...&Zhang, JC .(2016).Sodium alginate-functionalized nanodiamonds as sustained chemotherapeutic drug-release vectors.CARBON,97(-),78—86.
MLA Cui, ZF,et al."Sodium alginate-functionalized nanodiamonds as sustained chemotherapeutic drug-release vectors".CARBON 97.-(2016):78—86.
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