CAS OpenIR  > 中科院上海应用物理研究所2011-2018年
Sodium alginate-functionalized nanodiamonds as sustained chemotherapeutic drug-release vectors
Cui, ZF; Zhang, Y; Zhang, JC; Kong, HT; Tang, XX; Pan, L; Xia, K; Aldalbahi, A; Li, AG; Tai, RZ; Fan, CH; Zhu, Y; Zhang, JC (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Div Phys Biol, Shanghai 201800, Peoples R China.
2016
Source PublicationCARBON
ISSN0008-6223
Volume97Issue:-Pages:78—86
Subtype期刊文献
AbstractProlonged therapeutic action over an extended period of time on single dose is vital in designing an ideal drug delivery system. Nanoparticle-based vehicles for drug delivery serves as an ideal technology, however, utilization of them remains controversial due to potential safety concerns and transient drug retention. Nanodiamonds (NDs), with excellent biocompatibility and diversity of potential conjugates, have emerged as alternative promising materials in this regard. Here, we developed sodium alginate functionalized NDs (fNDs) for drug delivery. Cisplatin (DDP) was chosen as a model drug and coated on the negatively charged fNDs clusters. Our work demonstrated that fNDs were capable of enhancing drug accumulation and retention time in tumor cells, leading to continued tumor cell killing effect after clearance of drug treatment. Furthermore, fNDs-DDP treatment improved drug safety compared to DDP treatment. Thus, this new platform may have strong potential for further biomedical application. (C) 2015 Elsevier Ltd. All rights reserved.
KeywordAntitumor-activity Carbon Nanotubes Cancer-therapy Delivery Cisplatin Nanocarrier Cells Biocompatibility Therapeutics Accumulation
DOI10.1016/j.carbon.2015.07.066
Indexed BySCI
Language英语
WOS IDWOS:000366939900008
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/25835
Collection中科院上海应用物理研究所2011-2018年
Corresponding AuthorZhang, JC (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Div Phys Biol, Shanghai 201800, Peoples R China.
Recommended Citation
GB/T 7714
Cui, ZF,Zhang, Y,Zhang, JC,et al. Sodium alginate-functionalized nanodiamonds as sustained chemotherapeutic drug-release vectors[J]. CARBON,2016,97(-):78—86.
APA Cui, ZF.,Zhang, Y.,Zhang, JC.,Kong, HT.,Tang, XX.,...&Zhang, JC .(2016).Sodium alginate-functionalized nanodiamonds as sustained chemotherapeutic drug-release vectors.CARBON,97(-),78—86.
MLA Cui, ZF,et al."Sodium alginate-functionalized nanodiamonds as sustained chemotherapeutic drug-release vectors".CARBON 97.-(2016):78—86.
Files in This Item: Download All
File Name/Size DocType Version Access License
Sodium alginate-func(3279KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Cui, ZF]'s Articles
[Zhang, Y]'s Articles
[Zhang, JC]'s Articles
Baidu academic
Similar articles in Baidu academic
[Cui, ZF]'s Articles
[Zhang, Y]'s Articles
[Zhang, JC]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Cui, ZF]'s Articles
[Zhang, Y]'s Articles
[Zhang, JC]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Sodium alginate-functionalized nanodiamonds as sustained chemotherapeutic drug-release vectors.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.