中国科学院上海应用物理研究所机构知识库
Advanced  
CAS OpenIR  > 中科院上海应用物理研究所2011-2017年  > 期刊论文
题名:
Sodium alginate-functionalized nanodiamonds as sustained chemotherapeutic drug-release vectors
作者: Cui, ZF; Zhang, Y; Zhang, JC; Kong, HT; Tang, XX; Pan, L; Xia, K; Aldalbahi, A; Li, AG; Tai, RZ; Fan, CH; Zhu, Y
刊名: CARBON
出版日期: 2016
卷号: 97, 期号:-, 页码:78—86
关键词: ANTITUMOR-ACTIVITY ; CARBON NANOTUBES ; CANCER-THERAPY ; DELIVERY ; CISPLATIN ; NANOCARRIER ; CELLS ; BIOCOMPATIBILITY ; THERAPEUTICS ; ACCUMULATION
DOI: 10.1016/j.carbon.2015.07.066
通讯作者: Zhang, JC (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Div Phys Biol, Shanghai 201800, Peoples R China.
文章类型: 期刊文献
英文摘要: Prolonged therapeutic action over an extended period of time on single dose is vital in designing an ideal drug delivery system. Nanoparticle-based vehicles for drug delivery serves as an ideal technology, however, utilization of them remains controversial due to potential safety concerns and transient drug retention. Nanodiamonds (NDs), with excellent biocompatibility and diversity of potential conjugates, have emerged as alternative promising materials in this regard. Here, we developed sodium alginate functionalized NDs (fNDs) for drug delivery. Cisplatin (DDP) was chosen as a model drug and coated on the negatively charged fNDs clusters. Our work demonstrated that fNDs were capable of enhancing drug accumulation and retention time in tumor cells, leading to continued tumor cell killing effect after clearance of drug treatment. Furthermore, fNDs-DDP treatment improved drug safety compared to DDP treatment. Thus, this new platform may have strong potential for further biomedical application. (C) 2015 Elsevier Ltd. All rights reserved.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000366939900008
ISSN号: 0008-6223
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinap.ac.cn/handle/331007/25835
Appears in Collections:中科院上海应用物理研究所2011-2017年_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Sodium alginate-functionalized nanodiamonds as sustained chemotherapeutic drug-release vectors.pdf(3279KB)期刊论文作者接受稿开放获取View 联系获取全文

Recommended Citation:
Cui, ZF,Zhang, Y,Zhang, JC,et al. Sodium alginate-functionalized nanodiamonds as sustained chemotherapeutic drug-release vectors[J]. CARBON,2016-01-01,97(-):78—86.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Cui, ZF]'s Articles
[Zhang, Y]'s Articles
[Zhang, JC]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Cui, ZF]‘s Articles
[Zhang, Y]‘s Articles
[Zhang, JC]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Sodium alginate-functionalized nanodiamonds as sustained chemotherapeutic drug-release vectors.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace