CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Supersaturated polymeric micelles for oral cyclosporine A delivery: The role of Soluplus-sodium dodecyl sulfate complex
Xia, DN; Yu, HZ; Tao, JS; Zeng, JR; Zhu, QL; Zhu, CL; Gan, Y; Gan, Y (reprint author), Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd,Zhang Jiang Hi Tech Pk, Shanghai 201203, Peoples R China.
2016
Source PublicationCOLLOIDS AND SURFACES B-BIOINTERFACES
ISSN0927-7765
Volume141Issue:-Pages:301—310
Subtype期刊文献
AbstractOur previous study demonstrated that the retention of drug in the hydrophobic core of Soluplus micelle greatly impeded drug absorption from gastrointestinal tract. Using supersaturated polymeric micelles can improve drug release, however, insufficient maintaining of supersaturation of drug is still unfavorable for drug absorption. Here, we report adding small amount of small molecule, sodium dodecyl sulfate (SDS), to Soluplus solution can form a Soluplus-SDS complex. This complex not only showed a higher solubilization capability for the model drug cyclosporine A (CsA), but also maintained a longer period of and higher supersaturation than was achieved with Soluplus alone. The Soluplus-SDS interactions were characterized by analyzing surface tension, small-angle X-ray scattering (SAXS), fluorescence spectra, and nuclear magnetic resonance spectroscopy. The results demonstrated that the formation of Soluplus-SDS complex via SDS adsorption on hydrophobic segments of Soluplus, which have more hydrophobic domain than that of Soluplus micelle, contributed significantly to the solubilization and stabilization of supersaturated CsA. Using this amphiphilic copolymer-small molecule surfactant system, the cellular uptake and rat in vivo absorption of CsA were more effectively achieved than pure Soluplus. The area under the plasma concentration-time curve (AUC) and the maximal plasma concentration (Cmax) achieved by CsA-loaded Soluplus-SDS complex were 1.58- and 1.8-times higher than the corresponding values for CsA-loaded pure Soluplus, respectively. This study highlighted the benefits of Soluplus-SDS complex for optimizing the solubilization and oral absorption of a drug with low aqueous solubility. (C) 2016 Elsevier B.V. All rights reserved.
KeywordSolid Dispersions Administered Paclitaxel Cremophor-el Absorption Poly(Vinylpyrrolidone) Surfactants Dissolution Cellulose Pyrene
DOI10.1016/j.colsurfb.2016.01.047
Indexed BySCI
Language英语
WOS IDWOS:000374197700035
Citation statistics
Cited Times:27[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/25852
Collection中科院上海应用物理研究所2011-2019年
Corresponding AuthorGan, Y (reprint author), Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd,Zhang Jiang Hi Tech Pk, Shanghai 201203, Peoples R China.
Recommended Citation
GB/T 7714
Xia, DN,Yu, HZ,Tao, JS,et al. Supersaturated polymeric micelles for oral cyclosporine A delivery: The role of Soluplus-sodium dodecyl sulfate complex[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2016,141(-):301—310.
APA Xia, DN.,Yu, HZ.,Tao, JS.,Zeng, JR.,Zhu, QL.,...&Gan, Y .(2016).Supersaturated polymeric micelles for oral cyclosporine A delivery: The role of Soluplus-sodium dodecyl sulfate complex.COLLOIDS AND SURFACES B-BIOINTERFACES,141(-),301—310.
MLA Xia, DN,et al."Supersaturated polymeric micelles for oral cyclosporine A delivery: The role of Soluplus-sodium dodecyl sulfate complex".COLLOIDS AND SURFACES B-BIOINTERFACES 141.-(2016):301—310.
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